PCBP1 anticorps (Internal Region)
Aperçu rapide pour PCBP1 anticorps (Internal Region) (ABIN569643)
Antigène
Voir toutes PCBP1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- AA 234-247, Internal Region
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Séquence
- C-ADLAKLNQVA RQQSH
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Specificité
- Recognizes PCBP1 (234-247).
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Réactivité croisée (Details)
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Species reactivity (expected):Mouse, Rat, Canine (Dog).
Species reactivity (tested):Human. -
Purification
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
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Immunogène
- Peptide with sequence from the internal region of the protein sequence according to NP_006187.2. Genename: PCBP1
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 0.5 mg/mL
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Buffer
- Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PCBP1 (Poly(rC) Binding Protein 1 (PCBP1))
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Autre désignation
- PCBP1
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Sujet
- The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.Synonyms: Alpha-CP1, HNRPE1, HNRPX, Heterogeneous nuclear ribonucleoprotein E1, Nucleic acid-binding protein SUB2.3, Poly(rC)-binding protein 1, SUB2.3, hnRNP E1
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ID gène
- 5093
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NCBI Accession
- NP_006187
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UniProt
- Q15365
Antigène
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