CD1a anticorps
(9 références)Aperçu rapide pour CD1a anticorps (ABIN94018)
Antigène
Voir toutes CD1a AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Fonction
- Anti-Hu CD1a Purified
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Réactivité croisée (Details)
- Other not tested, Human
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Attributs du produit
- The antibody HI149 reacts with an extracellular epitope of CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas. The antibody does not react with peripheral blood T and B lymphocytes, monocytes, granulocytes, platelets and erythrocytes.
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Purification
- Purified by protein-A affinity chromatography.
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Pureté
- > 95 % (by SDS-PAGE)
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Immunogène
- Human thymocytes
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Isotype
- IgG1
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anti-CD1a (CD1a) antibody
CD1a Reactivité: Humain IHC, WB, ELISA, ICC Hôte: Souris Monoclonal 7A7 unconjugated
anti-CD1a (CD1a) (AA 151-250) antibodyCD1a Reactivité: Humain FACS, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) Hôte: Lapin Polyclonal unconjugated
anti-CD1a (CD1a) antibodyCD1a Reactivité: Humain IHC Hôte: Souris Monoclonal rC1A-711 unconjugated Recombinant Antibody
anti-CD1a (CD1a) antibody (PE)CD1a Reactivité: Humain FACS Hôte: Souris Monoclonal HI149 PE
anti-CD1a (CD1a) antibody (FITC)CD1a Reactivité: Humain FACS Hôte: Souris Monoclonal HI149 FITC
anti-CD1a (CD1a) antibody (APC)CD1a Reactivité: Humain FACS Hôte: Souris Monoclonal HI149 APC
anti-CD1a (CD1a) (AA 1-311) antibodyCD1a Reactivité: Humain WB, ELISA Hôte: Souris Monoclonal M1-2-1B5 unconjugated
anti-CD1a (CD1a) (full length) antibodyCD1a Reactivité: Humain IHC Hôte: Souris Monoclonal 001M unconjugated Recombinant Antibody
anti-CD1a (CD1a) antibodyCD1a Reactivité: Humain, Macaque rhésus FACS, IHC, IF, WB Hôte: Souris Monoclonal O10 unconjugated
anti-CD1a (CD1a) antibodyCD1a Reactivité: Humain IHC Hôte: Lapin Monoclonal C1A-1506R unconjugated Recombinant Antibody
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Indications d'application
- Flow cytometry: Recommended dilution: 1-5 μg/mL.
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Do not freeze
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Stock
- 4 °C
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Stockage commentaire
- Store at 2-8°C. Do not freeze.
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: "Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers." dans: Investigative ophthalmology & visual science, Vol. 48, Issue 10, pp. 4459-67, (2007) (PubMed).
: "CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts." dans: International immunology, Vol. 19, Issue 11, pp. 1271-9, (2007) (PubMed).
: "Dendritic cell recruitment in lesions of human and experimental pulmonary hypertension." dans: The European respiratory journal, Vol. 29, Issue 3, pp. 462-8, (2007) (PubMed).
: "Identification and characterization of human pulmonary dendritic cells." dans: American journal of respiratory cell and molecular biology, Vol. 32, Issue 3, pp. 177-84, (2005) (PubMed).
: "Triptolide, a constituent of immunosuppressive Chinese herbal medicine, is a potent suppressor of dendritic-cell maturation and trafficking." dans: Blood, Vol. 106, Issue 7, pp. 2409-16, (2005) (PubMed).
: "The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function." dans: Arthritis research & therapy, Vol. 7, Issue 3, pp. R694-703, (2005) (PubMed).
: "Langerhans cells utilize CD1a and langerin to efficiently present nonpeptide antigens to T cells." dans: The Journal of clinical investigation, Vol. 113, Issue 5, pp. 701-8, (2004) (PubMed).
: "Immunophenotypic analysis of hematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry." dans: Leukemia & lymphoma, Vol. 45, Issue 2, pp. 277-85, (2004) (PubMed).
: "Bacterial metabolite interference with maturation of human monocyte-derived dendritic cells." dans: Journal of leukocyte biology, Vol. 71, Issue 2, pp. 238-46, (2002) (PubMed).
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- CD1a
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Autre désignation
- CD1a
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Sujet
- CD1a molecule,CD1a, together with CD1b and c, belongs to group 1 of CD1 glycoproteins. These proteins serve as antigen-presenting molecules for a subset of T cells that responds to specific lipids and glycolipids found in the cell walls of bacterial pathogens or self-glycolipid antigens such as gangliosides, and they have also roles in antiviral immunity. Unlike CD1b, CD1a is excluded from late endosomal compartments and instead traffics independently in the recycling pathway of the early endocytic system, and CD1a antigen presentation is independent upon vesicular acidification.,T6, Leu-6, HTA1, FCB6
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ID gène
- 909
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UniProt
- P06126
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Pathways
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Antigène
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