Clusterin anticorps
Aperçu rapide pour Clusterin anticorps (ABIN238421)
Antigène
Voir toutes Clusterin (CLU) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Specificité
- Recognizes Apolipoprotein J (Apo J).
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Réactivité croisée (Details)
- Species reactivity (tested):Human. Negative in Bovine, Canine (Dog) and Feline (Cat).
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Attributs du produit
- Synonyms: Clusterin, APOJ, CLI, KUB1, AAG4, NA1/NA2, SP-40, 40, Complement-associated proteinSP-40, Complement cytolysis inhibitor, Testosterone-repressed prostate message 2,Ku70-binding protein 1, Aging-associated gene 4 protein
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Purification
- Affinity Chromatography on Protein A
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Immunogène
- Freshly ejaculated human sperms were washed in PBS and extracted in 3% acetic acid,10% glycerol, 30 mM benzaminidine. The acid extract was dialyzed against 0. 2% acetic acid and subsequently used forimmunization.
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Isotype
- IgG1
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anti-Clusterin (CLU) (AA 229-446) antibody
CLU Reactivité: Porc WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Clusterin (CLU) (AA 331-449) antibodyCLU Reactivité: Humain, Rat, Souris ELISA, FACS, IHC (p), IHC (fro), IF (p), IF (cc) Hôte: Lapin Polyclonal unconjugated
anti-Clusterin (CLU) (AA 227-448) antibodyCLU Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Clusterin (CLU) (AA 228-449) antibodyCLU Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Clusterin (CLU) (AA 226-447) antibodyCLU Reactivité: Lapin WB, IHC, IP, ICC Hôte: Souris Monoclonal C10 unconjugated
anti-Clusterin (CLU) (C-Term) antibodyVerified CLU Reactivité: Humain WB, IHC, ELISA, IF Hôte: Chèvre Polyclonal unconjugated
anti-Clusterin (CLU) (AA 71-99), (N-Term) antibodyCLU Reactivité: Humain, Rat, Souris WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB18701 unconjugated
anti-Clusterin (CLU) (AA 23-120) antibodyCLU Reactivité: Humain WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Clusterin (CLU) (AA 227-447) antibodyCLU Reactivité: Rat WB, IHC Hôte: Souris Monoclonal C1 unconjugated
anti-Clusterin (CLU) (C-Term) antibodyVerified CLU Reactivité: Rat, Souris WB, ELISA, IF Hôte: Chèvre Polyclonal unconjugated
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Indications d'application
- ELISA. Western blot: 1/ μg/mLPositive Material: seminal plasmaImmunocytochemistry. Immunohistochemistry on Paraffin Sections: 10 μg/mL. Positive Tissue: Sertoli cells.
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Restrictions
- For Research Use only
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Concentration
- 1.0 mg/mL
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Buffer
- PBS, pH ~7.4 with 15 mM Sodium Azide as preservative
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C/-20 °C
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Stockage commentaire
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Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch. -
Date de péremption
- 12 months
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- Clusterin (CLU)
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Autre désignation
- Apolipoprotein J (Apo J)
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Sujet
- Clusterin (APO J, SGP-2, TRPM-2, SP-40, pADHC-9, CLJ, T64, GP III, XIP8) is a 75-80 kD disulfide-linked heterodimeric protein containing about 30 % of N-linked carbohydrate rich in sialic acid but truncated forms targeted to the nucleus have also been identified. It is a conserved secreted glycoprotein expressed by a wide range of tissues and being implicated in many physiological processes, including e.g. lipid transportation, complement inhibition, tissue remodeling, membrane recycling, or clearence of cellular debris. It is nearly ubiqitously expressed in most mammalian tissues and can be found in plasma, milk, urine, cerebrospinal fluid and semen. Clusterin is able to bind and form complexes with numerous partners (immunoglobulins, lipids, heparin, bacteria, complement components, paraoxonase, beta amyloid, leptin etc.) and is expressed in many pathological and clinically relevant situations including cancer, organ regeneration, infection, Alzheimer disease, retinitis pigmentosa, myocardial infarction, renal tubular damage, autoimmunity and others. A genuine function of clusterin is still enigmatic.Synonyms: 40, 40, AAG4, APOJ, Aging-associated gene 4 protein, CLI, Clusterin, Complement cytolysis inhibitor, Complement-associated protein SP-40, KUB1, Ku70-binding protein 1, NA1/NA2, SP-40, Testosterone-repressed prostate message 2
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ID gène
- 1191
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UniProt
- P10909
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Pathways
- Apoptose, Negative Regulation of intrinsic apoptotic Signaling
Antigène
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