LCP2 anticorps (pTyr113)
(3 références)Aperçu rapide pour LCP2 anticorps (pTyr113) (ABIN967606)
Antigène
Voir toutes LCP2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- pTyr113
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Phosphorylated Human SLP-76 Peptide
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Isotype
- IgG1 kappa
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anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 202-463) antibody
LCP2 Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (N-Term) antibodyVerified LCP2 Reactivité: Humain WB, ELISA Hôte: Chèvre Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 284-533) antibodyLCP2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 216-434) antibodyLCP2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) antibodyLCP2 Reactivité: Humain WB, FACS Hôte: Lapin Monoclonal 25GB1910 unconjugated Recombinant Antibody
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 94-143), (pTyr128) antibodyLCP2 Reactivité: Humain, Souris, Rat WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 46-80) antibodyLCP2 Reactivité: Humain WB Hôte: Lapin Polyclonal RB56244 unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 303-337) antibodyLCP2 Reactivité: Humain WB Hôte: Lapin Polyclonal RB56245 unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 1-533) antibodyLCP2 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2) (AA 1-533) antibodyLCP2 Reactivité: Humain WB Hôte: Souris Polyclonal unconjugated
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Commentaires
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Related Products: ABIN967389
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 0.5 mg/mL
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Buffer
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C
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Stockage commentaire
- Store undiluted at 4°C.
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: "The SLP-76 family of adapter proteins." dans: Seminars in immunology, Vol. 16, Issue 6, pp. 379-93, (2004) (PubMed).
: "Adaptor proteins in lymphocyte activation." dans: Current opinion in immunology, Vol. 15, Issue 3, pp. 269-76, (2003) (PubMed).
: "Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 157, Issue 9, pp. 3769-73, (1996) (PubMed).
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- LCP2 (Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) (LCP2))
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Autre désignation
- SLP-76
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Sujet
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SLP-76 (SH2 domain-containing Leukocyte Protein of 76 kDa) is a tyrosine phosphoprotein that is involved in the T cell receptor (TCR)-mediated intracellular signaling pathway. It may be involved in the signaling pathways of other peripheral blood leukocytes, thymic/splenic cells, and in human T, B, and monocytic cell lines. SLP-76 consists of several motifs that signify its importance in protein-protein interactions involved in intracellular signaling pathways, such as the SH2 domain in the C-terminus, the three amino-terminus 17-amino acid repeats with conserved tyrosine and acidic residues (DYE(S/P)P), and a proline rich region. SLP-76 has been shown to associate with Gads, Grb2, PLCg1, SLAP-130, and Vav, all of which are part of the signaling cascade in T lymphocytes. An early event in the T cell activation pathway is the phosphorylation, by the Syk-family kinase ZAP-70, of SLP-76 at the three conserved tyrosine motifs, which then mediate interactions with downstream effectors. The phosphorylated tyrosine 113 (Y113) brings into the signaling complex the Rho-family guanine-nucleotide exchange factor Vav1, which is involved in the formation of a multimolecular assembly that participates in TCR-stimulated actin cytoskeletalrearrangement.
The J80-373 monoclonal antibody recognizes the phosphorylated Y113 of activated SLP-76. -
Poids moléculaire
- 76 kDa
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Pathways
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Antigène
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