PTPN11 anticorps (AA 1-177)
(5 références)Aperçu rapide pour PTPN11 anticorps (AA 1-177) (ABIN968068)
Antigène
Voir toutes PTPN11 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 1-177
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Réactivité croisée
- Souris, Rat (Rattus), Chien, Poulet, Grenouille
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Human PTP1D (SHP2) aa. 1-177
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Isotype
- IgG1
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anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 514-593) antibody
PTPN11 Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 263-329) antibodyPTPN11 Reactivité: Humain IHC, ELISA, ICC, FACS Hôte: Souris Monoclonal 6D9 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (C-Term) antibodyVerified PTPN11 Reactivité: Humain WB, ELISA, IF, FACS Hôte: Chèvre Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (C-Term) antibodyKO Validated PTPN11 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 69-99), (N-Term) antibodyPTPN11 Reactivité: Humain, Souris, Rat WB, IHC, IF, ICC, FACS Hôte: Souris Monoclonal 2E6 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 526-551) antibodyPTPN11 Reactivité: Humain WB, IHC (p), FACS Hôte: Lapin Polyclonal RB21493 unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 1-460) antibodyPTPN11 Reactivité: Humain WB, PLA Hôte: Souris Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) antibodyPTPN11 Reactivité: Humain WB, IF, IP Hôte: Lapin Monoclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (pTyr542) antibodyPTPN11 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (pTyr580) antibodyPTPN11 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
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Commentaires
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Related Products: ABIN968537, ABIN967389
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20° C.
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: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." dans: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, (2002) (PubMed).
: "Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 4, pp. 1948-58, (2002) (PubMed).
: "Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts." dans: Molecular and cellular biology, Vol. 22, Issue 11, pp. 3875-91, (2002) (PubMed).
: "Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 23, pp. 11239-43, (1993) (PubMed).
: "Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation." dans: Science (New York, N.Y.), Vol. 259, Issue 5101, pp. 1611-4, (1993) (PubMed).
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- PTPN11 (Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11))
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Autre désignation
- PTP1D
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Sujet
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SHP2 (also known as PTP1D, Syp, SHPTP2 and PTP2C) is a member of the cytosolic class of protein-tyrosine phosphatases (PTPs). SHP2 has been reported to contain two SH2 domains where both SH2 domains are N-terminal to the PTP catalytic domain. The expression of SHP2 has been reported to be highest in brain, heart, and kidney. The PTPs are thought to function with other protein-tyrosine kinases to maintain intracellular protein phosphotyrosine homeostasis and cell cycle progression. The presence of SH2 domains in SHP2 (PTP1D) has prompted speculation that binding to specific phosphorylated tyrosine residues is key to its function. SHP2 (PTP1D) is tyrosine- phosphorylated and activated in response to stimulation with EGF or PDGF.
Synonyms: PTP1D, Syp, SHPTP2 and PTP2C -
Poids moléculaire
- 65-72 kDa
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Pathways
- Signalistation JAK/STAT, Signalisation RTK, TCR Signaling, Interferon-gamma Pathway, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, BCR Signaling, L'effet Warburg
Antigène
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