STAT6 anticorps (pTyr641)
(3 références)Aperçu rapide pour STAT6 anticorps (pTyr641) (ABIN968594)
Antigène
Voir toutes STAT6 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- pTyr641
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Phosphorylated Human Stat6 (pY641)
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Isotype
- IgG2a
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anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 694-801) antibody
STAT6 Reactivité: Humain WB, ELISA, IF, IHC (p) Hôte: Souris Monoclonal 6C10 unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 1-180) antibodySTAT6 Reactivité: Humain WB, IF Hôte: Lapin Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 614-663) antibodySTAT6 Reactivité: Humain, Souris, Rat, Chien, Singe, Boeuf (Vache), Lapin, Porc, Cheval, Cobaye, Roussette (Chauve-souris), Hamster WB, IHC, IHC (p) Hôte: Lapin Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (pThr645) antibodySTAT6 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, IF, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (C-Term) antibodySTAT6 Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Cheval, Cobaye WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) antibodySTAT6 Reactivité: Humain, Souris WB, IHC, FACS, IHC (p), IF (cc) Hôte: Lapin Monoclonal 9A7 unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 557-841) antibodySTAT6 Reactivité: Rat WB, IHC Hôte: Lapin Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 1-847) antibodySTAT6 Reactivité: Humain WB, IF Hôte: Souris Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 694-801) antibodySTAT6 Reactivité: Humain WB, ELISA, IF Hôte: Souris Monoclonal 4G7 unconjugated
anti-Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6) (AA 1-847) antibodySTAT6 Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20° C.
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: "Requirements for interleukin-4-induced gene expression and functional characterization of Stat6." dans: Molecular and cellular biology, Vol. 16, Issue 10, pp. 5811-20, (1996) (PubMed).
: "Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis." dans: Molecular and cellular biology, Vol. 15, Issue 6, pp. 3336-43, (1995) (PubMed).
: "An interleukin-4-induced transcription factor: IL-4 Stat." dans: Science (New York, N.Y.), Vol. 265, Issue 5179, pp. 1701-6, (1994) (PubMed).
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- STAT6 (Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced (STAT6))
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Autre désignation
- Stat6
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Sujet
- Interleukin-4 (IL-4), a major immunoregulatory cytokine, is secreted by activated T lymphocytes, basophils, and mast cells and plays an important role in modulating T helper cell lineage development. It induces specific gene expression via the tyrosine phosphorylation of Stat6 at tyrosine 641 (Y641). Stat6, a member of the signal transducers and activators of transcription protein family, mediates signals for IL-4 and, possibly, IL-13. While Stat6 is widely expressed in human tissues, it exhibits elevated expression in peripheral blood lymphocytes, colon, intestine, ovary, prostate, thymus, spleen, kidney, liver, lung, and placenta. Following cytokine receptor ligation, Jak kinases are activated and phosphorylate the cytoplasmic tails of the oligomerized receptors. The SH3:SH2 domain of Stat6 associates with tyrosine-phosphorylated IL-4 receptor and the proximal Jak kinase phosphorylates Stat6 at Y641 on the C-terminal side of the SH2 domain. Stat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. Thus, Stat6 mediates the IL-4 signal and is essential for the proper development of adaptive immunity. Immunofluorescent labelling of phosphorylated Stat6 in endothelial cells exposed to 10 ng/ml IL-4 for 1 hour.
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Poids moléculaire
- 100 kDa
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Pathways
- Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response
Antigène
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