TAF4 anticorps (AA 454-565)
(4 références)Aperçu rapide pour TAF4 anticorps (AA 454-565) (ABIN968728)
Antigène
Voir toutes TAF4 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 454-565
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Réactivité croisée
- Souris
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Human TAF[II]135 aa. 454-565
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Isotype
- IgG1
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anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) (AA 1021-1062) antibody
TAF4 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB56278 unconjugated
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) antibodyTAF4 Reactivité: Humain, Souris WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) (AA 6-1085) antibodyTAF4 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) antibodyTAF4 Reactivité: Souris, Rat IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) (AA 935-984) antibodyTAF4 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poulet, Porc, Roussette (Chauve-souris), Singe, Xenopus laevis WB Hôte: Lapin Polyclonal unconjugated
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) (AA 715-800) antibodyTAF4 Reactivité: Humain WB, ELISA Hôte: Souris Polyclonal unconjugated
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) antibodyTAF4 Reactivité: Humain WB, ELISA Hôte: Lapin Polyclonal unconjugated
anti-TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4) (Middle Region) antibodyTAF4 Reactivité: Humain, Souris, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin WB, ChIP Hôte: Lapin Polyclonal unconjugated
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Commentaires
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Related Products: ABIN968537, ABIN967389
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20°C.
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: "Redundant role of tissue-selective TAF(II)105 in B lymphocytes." dans: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6564-72, (2002) (PubMed).
: "Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription. ..." dans: Nature genetics, Vol. 26, Issue 1, pp. 29-36, (2000) (PubMed).
: "Distinct subdomains of human TAFII130 are required for interactions with glutamine-rich transcriptional activators." dans: Molecular and cellular biology, Vol. 18, Issue 10, pp. 5734-43, (1998) (PubMed).
: "Human TAF(II)135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells." dans: Genes & development, Vol. 11, Issue 11, pp. 1381-95, (1997) (PubMed).
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- TAF4 (TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa (TAF4))
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Autre désignation
- TAF II135
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Sujet
- Tightly associated factors (TAFs) play an essential role in transcriptional activation through their interaction with a variety of activators. TAF[II]135 (a.k.a. TAF[II]130) is a human homologue of Drosophila TAF[II]110, the first TAF shown to have coactivator activity. TAF[II]135 contains multiple glutamine-rich regions, as well as a coactivator domain (CAD). The glutamine-rich regions of TAF[II]135 facilitate interaction with Sp1 and CREB, which leads to enhancement of both Sp1- and CREB-mediated transcription. In addition, TAF[II]135 can potentiate transcriptional stimulation by AF-2 of the retinoic acid, thyroid hormone, and vitamine D3 receptors. However, TAF[II]135 does not interact with the AF-2s of the estrogen and retinoid X receptors. Interestingly, TAF[II]135 enhancement of CREB transcriptional activity may be disrupted by expanded polyglutamine (CAG) repeats found in at least eight different neurodegenerative disorders. Thus, TAF[II]135 may have important coactivator activities in many different transcription-regulating cell signaling pathways, and interference of TAF[II]135 activity by CAG repeats may be a common mechanism of specific types of neuropathologies.
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Poids moléculaire
- 135 kDa
Antigène
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