alpha Adaptin anticorps (AA 38-215)
(5 références)Aperçu rapide pour alpha Adaptin anticorps (AA 38-215) (ABIN968008)
Antigène
Voir toutes alpha Adaptin (AP2A1) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 38-215
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Réactivité croisée
- Rat (Rattus), Humain, Chien
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Mouse Adaptin alpha [A] aa. 38-215
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Isotype
- IgG1
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anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 706-727) antibody
Verified AP2A1 Reactivité: Humain WB, ELISA Hôte: Chèvre Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 38-215) antibodyAP2A1 Reactivité: Humain, Souris, Rat, Chien WB, IF, IP, BI, IHC (f) Hôte: Souris Monoclonal 8-Adaptin alpha unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 1-260) antibodyAP2A1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 Reactivité: Humain WB, IF Hôte: Lapin Monoclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) antibodyAP2A1 Reactivité: Humain, Souris WB, IHC, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 706-735), (C-Term) antibodyAP2A1 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB34053 unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 1-260) antibodyAP2A1 Reactivité: Humain IHC, ELISA Hôte: Lapin Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 612-661) antibodyAP2A1 Reactivité: Humain, Souris, Rat, Cheval, Lapin, Cobaye, Singe WB Hôte: Lapin Polyclonal unconjugated
anti-Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1) (AA 600-650) antibodyAP2A1 Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
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Commentaires
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Related Products: ABIN968545, ABIN967389
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20°C.
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: "Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif." dans: Traffic (Copenhagen, Denmark), Vol. 4, Issue 7, pp. 468-78, (2003) (PubMed).
: "Enthoprotin: a novel clathrin-associated protein identified through subcellular proteomics." dans: The Journal of cell biology, Vol. 158, Issue 5, pp. 855-62, (2002) (PubMed).
: "Numb is an endocytic protein." dans: The Journal of cell biology, Vol. 151, Issue 6, pp. 1345-52, (2001) (PubMed).
: "The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors." dans: The Journal of biological chemistry, Vol. 276, Issue 21, pp. 18392-8, (2001) (PubMed).
: "Cloning of cDNAs encoding two related 100-kD coated vesicle proteins (alpha-adaptins)." dans: The Journal of cell biology, Vol. 108, Issue 3, pp. 833-42, (1989) (PubMed).
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- alpha Adaptin (AP2A1) (Adaptor-Related Protein Complex 2, alpha 1 Subunit (AP2A1))
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Autre désignation
- Adaptin alpha
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Sujet
- Sorting of integral membrane proteins at various stages of the endocytic and secretory pathways is mediated by vesicular trafficking between a variety of organelles. Two sorting signals are tyrosine-based and dileucine-based signals that interact with heterotetrameric adaptor protein complexes (AP-1, AP-2, AP-3, and AP-4), which are associated with the vesicle coats. These coatomers contain two large Adaptin proteins (alpha, gamma, delta, or epsilon and beta1, beta2, beta3, or beta4, respectively) that are noncovalently linked to one medium chain (µ1, µ2, µ3, or µ4) and one small chain (sigma1, sigma2, sigma3, or sigma4). The AP-1 and AP-3 complexes are involved in protein sorting from the TGN and endosomes, while AP-2 adaptor complexes are involved in clathrin-mediated endocytosis. In the AP-2 complex, Adaptin alpha is expressed in two very similar isoforms from two different genes. Adaptin alpha [A] (112kDa) is expressed primarily in brain, while Adaptin alpha [C] (105kDa) is expressed in brain, liver and other tissues. This antibody is routinely tested by western blot analysis.
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Poids moléculaire
- 112 kDa
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Pathways
- Signalisation Notch, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation
Antigène
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