IKBKG anticorps (AA 278-396)
(5 références)Aperçu rapide pour IKBKG anticorps (AA 278-396) (ABIN968464)
Antigène
Voir toutes IKBKG AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 278-396
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Réactivité croisée
- Rat (Rattus), Humain, Chien
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Attributs du produit
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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Immunogène
- Mouse IKKgamma/NEMO aa. 278-396
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Isotype
- IgG1
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anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibody
IKBKG Reactivité: Humain WB, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibodyIKBKG Reactivité: Humain WB, ELISA, IF, IHC (p), PLA Hôte: Souris Monoclonal 4G9 unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) antibodyIKBKG Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-110) antibodyIKBKG Reactivité: Humain WB, ELISA, IF Hôte: Souris Monoclonal 1D4 unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (AA 1-419) antibodyIKBKG Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (pSer31) antibodyIKBKG Reactivité: Humain WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (pSer85) antibodyIKBKG Reactivité: Humain, Souris WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (N-Term) antibodyIKBKG Reactivité: Humain, Souris WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) antibodyKD Validated IKBKG Reactivité: Humain WB, FACS Hôte: Souris Monoclonal 24GB14145 unconjugated
anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG) (Ser85) antibodyIKBKG Reactivité: Humain WB, ELISA, IF Hôte: Lapin Polyclonal unconjugated
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Commentaires
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Related Products: ABIN968547, ABIN967389
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- 250 μg/mL
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Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- -20 °C
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Stockage commentaire
- Store undiluted at -20° C.
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: "Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor." dans: Immunity, Vol. 18, Issue 1, pp. 13-26, (2003) (PubMed).
: "IKKgamma mediates the interaction of cellular IkappaB kinases with the tax transforming protein of human T cell leukemia virus type 1." dans: The Journal of biological chemistry, Vol. 274, Issue 22, pp. 15297-300, (1999) (PubMed).
: "Role of adapter function in oncoprotein-mediated activation of NF-kappaB. Human T-cell leukemia virus type I Tax interacts directly with IkappaB kinase gamma." dans: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17402-5, (1999) (PubMed).
: "IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex." dans: Nature, Vol. 395, Issue 6699, pp. 297-300, (1998) (PubMed).
: "Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation." dans: Cell, Vol. 93, Issue 7, pp. 1231-40, (1998) (PubMed).
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- IKBKG (Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase gamma (IKBKG))
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Autre désignation
- IKK gamma
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Sujet
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In most cells, NF-kappaB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IkappaBalpha, IkappaBbeta, and IkappaBepsilon. Cell stimulation induces the release, activation, and nuclear translocation of NF-kappaB. Release of NF-kappaB results from the phosphorylation and subsequent proteolytic degradation of the IkappaB proteins. Two cytokine-inducible IkappaB kinases (IKKalpha and IKKbeta) phosphorylate and target the IkappaB proteins for degradation by the ubiquitin pathway. These kinases are components of a 700-900 kDa multisubunit complex that also contains NF-kappaB/RelA, IkappaBalpha, MEKK1, NIK, IKAP, and IKKgamma/NEMO (NF-kappaB essential modulator). IKKgamma contains two coiled-coil domains and a leucine zipper which allow it to form dimers and trimers that interact directly with IKKbeta. IKKgamma, essential for IKKalpha/IKKbeta activation of NF-kappaB, is located functionally and physically upstream of these subunits. In addition, IKKgamma enables the HTLV-1 Tax oncoprotein to interact with IKKbeta, resulting in constitutive activation of NF-kappaB and maintenance of cellular transformation. Thus, IKKgamma is an essential element of the IkappaB complex and an adaptor that mediates stable formation of Tax-IKK complexes.
Synonyms: NEMO -
Poids moléculaire
- 48 kDa
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Pathways
- Signalisation NF-kappaB, Signalisation RTK, TCR Signaling, Signalisation TLR, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, M Phase, Production of Molecular Mediator of Immune Response, Hepatitis C, Protein targeting to Nucleus, Toll-Like Receptors Cascades, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
Antigène
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