ATP6V1C1 anticorps (N-Term)
(1 reference)Aperçu rapide pour ATP6V1C1 anticorps (N-Term) (ABIN406715)
Antigène
Voir toutes ATP6V1C1 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Épitope
- N-Term
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Séquence
- ldafvegvvk kvaqymadvl edskdkvqen llangvdlvt yitrfqwdma
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Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%
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Attributs du produit
- This is a rabbit polyclonal antibody against ATP6V1C1. It was validated on Western Blot using a cell lysate as a positive control.
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Purification
- Affinity Purified
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Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human ATP6V1C1
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anti-ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1) antibody
ATP6V1C1 Reactivité: Humain, Rat, Souris WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1) (AA 129-382) antibodyATP6V1C1 Reactivité: Humain ELISA, IHC, IF Hôte: Lapin Polyclonal unconjugated
anti-ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1) (AA 1-382) antibodyATP6V1C1 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1) (AA 1-110) antibodyATP6V1C1 Reactivité: Humain WB, ELISA Hôte: Souris Polyclonal unconjugated
anti-ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1) (AA 61-110) antibodyATP6V1C1 Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cheval, Lapin, Roussette (Chauve-souris), Poulet, Hamster, Singe WB Hôte: Lapin Polyclonal unconjugated
anti-ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1) (N-Term) antibodyATP6V1C1 Reactivité: Humain, Rat, Souris WB Hôte: Lapin Polyclonal unconjugated
anti-ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1) (N-Term) antibodyATP6V1C1 Reactivité: Humain, Rat, Souris, Boeuf (Vache), Chien, Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
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Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
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Commentaires
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Antigen size: 382 AA
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Restrictions
- For Research Use only
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Format
- Liquid
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Concentration
- Lot specific
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Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
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Stock
- -20 °C
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Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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: "V-ATPase: a master effector of E2F1-mediated lysosomal trafficking, mTORC1 activation and autophagy." dans: Oncotarget, Vol. 6, Issue 29, pp. 28057-70, (2015) (PubMed).
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- ATP6V1C1 (ATPase, H+ Transporting, Lysosomal 42kDa, V1 Subunit C1 (ATP6V1C1))
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Autre désignation
- ATP6V1C1
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Sujet
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ATP6V1C1 is a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D.This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene is one of two genes that encode the V1 domain C subunit proteins and is found ubiquitously. This C subunit is analogous but not homologous to gamma subunit of F-ATPases. Previously, this gene was designated ATP6D. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: ATP6C, ATP6D, FLJ20057, VATC, Vma5
Protein Interaction Partner: ATP6V1C1, IVNS1ABP, ATG7, DNM1L, TSN, STAT1, SNX2, SNX1, SHMT2, SHMT1, SARS, RDX, PAWR, NASP, IDE, GTF2A1, GSPT1, CTTN, PSMG3, ANP32E, TBC1D15, SNX6, VPS35, VPS29, LUC7L2, VTA1, ARFIP1, GSPT2, UBC, UBAC2, TXNDC17, MRPS35, CISD1, VASP, TYMS, SSR1, SRSF5, A
Protein Size: 382 -
Poids moléculaire
- 42 kDa
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ID gène
- 528
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NCBI Accession
- NM_001695, NP_001686
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UniProt
- P21283
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Pathways
- Transition Metal Ion Homeostasis, Proton Transport
Antigène
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