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APP anticorps (AA 666-670)

L’anticorps anti-APP Polyclonal Lapin est utilisé pour la détection de APP dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et IF.
N° du produit ABIN362849
268,40 €
Plus frais de livraison 40,00 € et TVA
Destination: France
Envoi sous 10 à 14 jours ouvrables

Aperçu rapide pour APP anticorps (AA 666-670) (ABIN362849)

Antigène

Voir toutes APP Anticorps
APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivité

  • 282
  • 125
  • 123
  • 11
  • 9
  • 8
  • 8
  • 8
  • 8
  • 7
  • 6
  • 5
  • 4
  • 4
  • 3
  • 1
  • 1
  • 1
  • 1
Humain, Souris, Rat

Hôte

  • 218
  • 81
  • 24
  • 4
  • 4
  • 1
Lapin

Clonalité

  • 225
  • 103
  • 2
Polyclonal

Conjugué

  • 185
  • 27
  • 19
  • 18
  • 7
  • 6
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
Cet anticorp APP est non-conjugé

Application

  • 196
  • 138
  • 90
  • 55
  • 52
  • 52
  • 43
  • 43
  • 36
  • 18
  • 15
  • 6
  • 5
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (IF)
  • Épitope

    • 30
    • 27
    • 24
    • 23
    • 18
    • 17
    • 11
    • 8
    • 8
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 666-670

    Specificité

    The antibody detects endogenous level of total APP protein.

    Purification

    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific immunogen.

    Immunogène

    Peptide sequence around AA 666-670 (A-V-T-P-E ) derived from Human APP. Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.

    Isotype

    IgG
  • Indications d'application

    Western blotting: 1:500-1:1000
    Immunofluorescence: 1:100-1:200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

    Agent conservateur

    Sodium azide

    Précaution d'utilisation

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Stock

    4 °C/-20 °C

    Stockage commentaire

    Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
  • Antigène

    APP (Amyloid beta (A4) Precursor Protein (APP))

    Autre désignation

    APP

    Sujet

    APP encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.

    Poids moléculaire

    100-140 kDa

    NCBI Accession

    NP_000475

    UniProt

    P05067

    Pathways

    Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour
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