Cathepsin D anticorps
Aperçu rapide pour Cathepsin D anticorps (ABIN783842)
Antigène
Voir toutes Cathepsin D (CTSD) AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
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Specificité
- This antibody detects both the 52 kDa proform and the 34 kDa cleaved fragment of Cathepsin D.
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Réactivité croisée (Details)
- Species reactivity (tested):Human, Mouse, Rat.
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Purification
- Affinity chromatography
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Immunogène
- Synthetic peptide surrounding amino acid 140 of mouse cathepsins D
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Isotype
- IgG
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anti-Cathepsin D (CTSD) (C-Term) antibody
CTSD Reactivité: Humain, Souris, Rat, Singe, Hamster, Boeuf (Vache), Porc, Lapin, Chien, Cheval, Cobaye, Avian, Cat, Poulet, Âne, Chévre, Mouton WB, IF, IHC (p), IHC (fro), IEM Hôte: Chèvre Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 66-410) antibodyCTSD Reactivité: Souris WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 26-412) antibodyCTSD Reactivité: Humain WB, ELISA, IP, IHC (p) Hôte: Souris Monoclonal 3F12-1B9 unconjugated
anti-Cathepsin D (CTSD) (AA 1-412) antibodyCTSD Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 104-250) antibodyCTSD Reactivité: Humain WB, IHC Hôte: Souris Monoclonal CTSD-3082 unconjugated
anti-Cathepsin D (CTSD) (AA 120-407) antibodyCTSD Reactivité: Rat WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 21-412) antibodyCTSD Reactivité: Humain WB, IHC, IP, ICC Hôte: Souris Monoclonal C7 unconjugated
anti-Cathepsin D (CTSD) (AA 104-250) antibodyCTSD Reactivité: Humain WB, IHC, IF Hôte: Souris Monoclonal CTSD-3276 unconjugated
anti-Cathepsin D (CTSD) (C-Term) antibodyCTSD Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cheval, Cobaye, Saccharomyces cerevisiae, Poisson zèbre (Danio rerio) WB Hôte: Lapin Polyclonal unconjugated
anti-Cathepsin D (CTSD) (AA 201-412) antibodyCTSD Reactivité: Humain WB, IHC, ICC, IF, FACS Hôte: Lapin Polyclonal unconjugated
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Indications d'application
- Optimal working dilution should be determined by the investigator.
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Restrictions
- For Research Use only
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Concentration
- 0.5 mg/mL
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Buffer
- PBS, pH 7.2, 0.01 % Thimerosal, 30 % Glycerol, 0.5 % BSA
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Agent conservateur
- Thimerosal (Merthiolate)
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Précaution d'utilisation
- This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Conseil sur la manipulation
- Avoid repeated freezing and thawing.
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Stock
- -20 °C
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Stockage commentaire
- Upon receipt, store (in aliquots) at -20 to -70 °C.
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- Cathepsin D (CTSD)
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Autre désignation
- Cathepsin D
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Sujet
- Cathepsin D is a normal lysosomal protease that is expressed in all cells. It is an aspartyl protease with a pH optimum in the range of 3-5, and contains two N-linked oligosaccharides. Cathepsin D is synthesized as an inactive 52 kDa pro-enzyme. Activation involves the proteolytic removal of the 43 amino acid profragment and an internal cleavage to generate the two-chain form made up of 34 and 14 kDa subunits. Cathepsin D contains the mannose-6-phosphate lysosomal localization signal that targets the enzyme to the lysosomal compartment where it functions in the normal degradation of proteins. In certain tumor cells, Cathepsin D is abnormally processed and is secreted in its 52 kDa precursor form. Numerous clinical studies as well as in vitro evidence suggest that cathepsin D plays an important role in malignant transformation and may be a useful prognostic indicator for breast cancer.Synonyms: CPSD, CTSD
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ID gène
- 1509
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NCBI Accession
- NP_001900
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UniProt
- P07339
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Pathways
- Peptide Hormone Metabolism
Antigène
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