PIAS2 anticorps (C-Term)
Aperçu rapide pour PIAS2 anticorps (C-Term) (ABIN388059)
Antigène
Voir toutes PIAS2 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
-
-
Épitope
- AA 518-547, C-Term
-
Homologie
- Rat
-
Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
-
Immunogène
- This PIAS2 (PIASx1/2) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 518-547 amino acids from the C-terminal region of human PIAS2 (PIASx1/2).
-
Isotype
- Ig Fraction
-
-
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 385-473) antibody
PIAS2 Reactivité: Humain WB, ELISA, IF, PLA, RNAi Hôte: Souris Monoclonal 1F7 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 Reactivité: Humain WB, IF Hôte: Souris Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) antibodyPIAS2 Reactivité: Humain, Souris, Rat, Singe WB, ELISA, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 Reactivité: Humain, Souris, Chien, Boeuf (Vache), Cheval, Lapin WB Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 109-140), (N-Term) antibodyPIAS2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB0678 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-30), (C-Term) antibodyPIAS2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB0676 unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 Reactivité: Humain WB, PLA Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (AA 1-572) antibodyPIAS2 Reactivité: Humain WB, IP Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (N-Term) antibodyPIAS2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 2 (PIAS2) (C-Term) antibodyPIAS2 Reactivité: Humain, Souris, Chien, Boeuf (Vache), Cheval, Lapin WB, IHC Hôte: Lapin Polyclonal unconjugated
-
-
Indications d'application
- IHC-P: 1:50~100
-
Restrictions
- For Research Use only
-
-
-
Format
- Liquid
-
Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
Agent conservateur
- Sodium azide
-
Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Stock
- 4 °C,-20 °C
-
Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
-
Date de péremption
- 6 months
-
-
- PIAS2 (Protein Inhibitor of Activated STAT, 2 (PIAS2))
-
Autre désignation
- PIAS2 (PIASx1/2)
-
Sujet
- PIASX functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. PIASX binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha.
-
Poids moléculaire
- 68240
-
ID gène
- 9063
-
NCBI Accession
- NP_004662, NP_775298
-
UniProt
- O75928
-
Pathways
- Signalistation JAK/STAT, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling
Antigène
-
