PIAS4 anticorps (N-Term)
(2 références)Aperçu rapide pour PIAS4 anticorps (N-Term) (ABIN388061)
Antigène
Voir toutes PIAS4 AnticorpsReactivité
Hôte
Clonalité
Conjugué
Application
Clone
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Épitope
- AA 48-79, N-Term
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Purification
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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Immunogène
- This PIASy antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-79 amino acids from the N-terminal region of human PIASy.
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Isotype
- Ig Fraction
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anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (C-Term) antibody
PIAS4 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (AA 471-499), (C-Term) antibodyPIAS4 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB00682 unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (AA 1-510) antibodyPIAS4 Reactivité: Humain WB Hôte: Souris Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (AA 44-73), (N-Term) antibodyPIAS4 Reactivité: Souris WB Hôte: Lapin Polyclonal RB33956 unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (AA 66-241) antibodyPIAS4 Reactivité: Humain ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (AA 60-260) antibodyPIAS4 Reactivité: Humain WB Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (N-Term) antibodyPIAS4 Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Poisson zèbre (Danio rerio), Singe, Roussette (Chauve-souris), Poulet, Porc, Hamster, Xenopus laevis WB Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (AA 44-60) antibodyPIAS4 Reactivité: Humain, Singe WB, ICC Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (AA 451-500) antibodyPIAS4 Reactivité: Humain, Souris WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
anti-Protein Inhibitor of Activated STAT, 4 (PIAS4) (N-Term) antibodyPIAS4 Reactivité: Humain WB, IHC (p), EIA Hôte: Lapin Polyclonal unconjugated
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Indications d'application
- WB: 1:1000. IHC-P: 1:50~100
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Restrictions
- For Research Use only
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Format
- Liquid
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Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
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Agent conservateur
- Sodium azide
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Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Stock
- 4 °C,-20 °C
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Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
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Date de péremption
- 6 months
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: "Activation of the SUMO modification system is required for the accumulation of RAD51 at sites of DNA damage." dans: Journal of cell science, Vol. 126, Issue Pt 22, pp. 5284-92, (2013) (PubMed).
: "The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through ..." dans: The Journal of biological chemistry, Vol. 281, Issue 35, pp. 25850-66, (2006) (PubMed).
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- PIAS4 (Protein Inhibitor of Activated STAT, 4 (PIAS4))
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Autre désignation
- PIASy
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Sujet
- PIASy1 functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. This protein plays a crucial role in transcriptional coregulation of various cellular pathways, including the STAT pathway, the p53 pathway, the wnt pathway and the steroid hormone signaling pathway. PIASy1 is involved in gene silencing, and promotes PARK7 sumoylation.
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Poids moléculaire
- 56504
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ID gène
- 51588
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NCBI Accession
- NP_056981
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UniProt
- Q8N2W9
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Pathways
- Signalistation JAK/STAT, Interferon-gamma Pathway, Positive Regulation of Response to DNA Damage Stimulus
Antigène
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