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SNCA anticorps (pTyr133)

Cet anticorps Lapin Polyclonal détecte spécifiquement SNCA dans IF. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

N° du produit ABIN362366

378,40 €

Plus frais de livraison 40,00 € et TVA

Destination: France

Envoi sous 10 à 14 jours ouvrables

Aperçu rapide pour SNCA anticorps (pTyr133) (ABIN362366)

Antigène

Voir toutes SNCA Anticorps

SNCA (Synuclein, alpha (SNCA))

Reactivité

Humain, Souris, Rat

Hôte

Lapin

Clonalité

Polyclonal

Conjugué

Cet anticorp SNCA est non-conjugé

Application

Immunofluorescence (IF)

Discover our top product SNCA Anticorps primaire

Épitope
75

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pTyr133

Specificité

The antibody detects endogenous level of a-Synuclein only when phosphorylated at tyrosine 133.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Immunogène

Peptide sequence around phosphorylation site of pTyr133 (E-G-Y (p) -Q-D) derived from Human a-Synuclein. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Isotype

IgG
anti-Synuclein, alpha (SNCA) (pSer129) antibody
SNCA Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PerCP)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 PerCP

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PE)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 PE

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 488)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 Atto 488

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 390)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 Atto 390

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Atto 594)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 Atto 594

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (Biotin)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 Biotin

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (FITC)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 FITC

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (APC)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 APC

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (HRP)
SNCA Reactivité: Humain WB, ELISA, IHC, ICC Hôte: Lapin Monoclonal J18 HRP

Indications d'application

Western blotting: 1:500-1:1000
Immunofluorescence: 1:100-1:200

Restrictions

For Research Use only
Format

Liquid

Concentration

1 mg/mL

Buffer

Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur

Sodium azide

Précaution d'utilisation

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock

4 °C/-20 °C

Stockage commentaire

Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
Antigène

SNCA (Synuclein, alpha (SNCA))

Autre désignation

alpha-Synuclein

Sujet

SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons

Poids moléculaire

18 kDa

NCBI Accession

NP_000336

UniProt

P37840

Pathways

Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity