anti-7-Dehydrocholesterol Reductase (DHCR7) Anticorps

DHCR7 encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. De plus, nous expédions DHCR7 Kits (9) et DHCR7 Protéines (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
DHCR7 13360 O88455
DHCR7 64191 Q9Z2Z8
DHCR7 1717 Q9UBM7
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Top anti-DHCR7 Anticorps sur anticorps-enligne.fr

Showing 10 out of 44 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Souris Lapin Inconjugué IF, IHC (p), WB DHCR7 Antibody (C-term) (ABIN655399) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Human HL-60 cell lysates probed with Anti-DHCR7 Polyclonal Antibody, Unconjugated  at 1:300 overnight at 4˚C. Followed by a conjugated secondary antibody -HRP) at 1:10000 for 90 min at 37˚C. 100 μL Connectez-vous pour afficher 9 to 12 Days
304,36 €
Détails
Humain Lapin Inconjugué IHC, WB Western blot analysis of extracts of various cells, using DHCR7 antibody. 100 μL Connectez-vous pour afficher 12 Days
261,90 €
Détails
Humain Lapin Alexa Fluor 594 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin Cy5.5 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin FITC IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin Cy3 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin Cy5 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin Cy7 IF (p)   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails
Humain Lapin HRP IHC (p), WB   100 μL Connectez-vous pour afficher 18 to 22 Days
414,64 €
Détails

DHCR7 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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Plus d’anticorps contre DHCR7 partenaires d’interaction

Xenopus laevis 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. Results suggest that 7-dehydrocholesterol reductase and Sonic Hedgehog (Montrer SHH Anticorps) are co-expressed during midline development in Xenopus embryos.

  2. Data from Xdhcr7 overexpression and knockdown experiments reveals that a tight control of cholesterol synthesis is particularly important for proper development of the central and peripheral nervous system

Arabidopsis thaliana 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. both Delta(5,7)-sterol-Delta(7)-reductase and Delta(24)-sterol-Delta(24)-reductase are in addition localized to the plasma membrane, whereas Delta(7)-sterol-C(5)-desaturase was clearly detected in lipid particles

Mouse (Murine) 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. Dhcr7 heterozygous mice made fewer ultrasonic vocalizations. Increases of 7-DHC and expression of the serotonin transporter (Montrer SLC6A4 Anticorps) were observed in the compound mutant mice.

  2. Studied the effect of 7-dehydrocholesterol reductase (Dhcr7) and identified signal pathways involved in regulation of embryonic palatogenesis. Expression changes of Dhcr7, Sonic Hedgehog (Shh (Montrer SHH Anticorps)), and bone morphogenetic protein-2 (Bmp2 (Montrer BMP2 Anticorps)) were measured by RT-PCR and WB after Dhcr7 gene silencing and the addition of exogenous cholesterol.

  3. significant increases in Col1a1 (Montrer COL1A1 Anticorps), serine/threonine-protein kinase 1, Ctnnb1 (Montrer CTNNB1 Anticorps), CSRNP1 (Montrer CSRNP1 Anticorps), Ddit4 (Montrer DDIT4 Anticorps), Cyp2e1 (Montrer CYP2E1 Anticorps), and Krit1 (Montrer KRIT1 Anticorps) expressions and great decreases inreceptor D2, Neu1 (Montrer NEURL Anticorps), and Dhcr7 expressions following long-term exposure to TiO2 NPs (Montrer NPS Anticorps)

  4. data indicate an underlying dysfunction of the 5-HT2A receptors in Dhcr7-HET mice that warrants further investigation to establish how this may relate to behavioral disturbances in human patients carrying Dhcr7 mutations

  5. conclude that cytochrome P450 reductase (Montrer POR Anticorps) is not involved in 7-dehydrocholesterol reductase activity

  6. Data suggest that although cholesterol synthesis is impaired in both Dhcr7 mutant and Sc5d (Montrer SC5DL Anticorps)(-/-) embryonic brain, synthesis of nonsterol isoprenoids may be increased and thus contribute to Smith-Lemli-Opitz syndrome and lathosterolosis pathology.

  7. Immunohistochemical analyses have revealed a 306% increase in the area of 5-HT (Montrer DDC Anticorps) immunoreactivity (5-HT (Montrer DDC Anticorps) IR) in the hindbrains of mutant (Dhcr7-/-) mice as compared to age-matched wild type animals.

  8. Of the 12,000 genes analyzed, 91 were upregulated and 98 were downregulated in the Dhcr7-/- hindbrains when compared to wild-type animals.

  9. CNS defects caused by Dhcr7 null likely play a major role in the lethal pathogenesis of Dhcr7-/- mice, with the peripheral organs contributing the morbidity

  10. Data show that in vitro down regulation of NRIF (Montrer ZFP110 Anticorps) expression decreased the mRNA for two main cholesterogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Montrer HMGCR Anticorps) and 7-dehydrocholesterol reductase.

Human 7-Dehydrocholesterol Reductase (DHCR7) interaction partners

  1. phosphorylation modulates DHCR7 activity in cells, and contributes to the overall synthesis of cholesterol, and probably vitamin D

  2. Allelic variations in CYP2R1 (Montrer CYP2R1 Anticorps) and GC affect vitamin D levels, but variant alleles on VDR (Montrer CYP27B1 Anticorps) and DHCR7 were not correlated with vitamin D deficiency.

  3. Genetic variations in ABCG5 (Montrer ABCG5 Anticorps), CYP7A1 (Montrer CYP7A1 Anticorps), and DHCR7 may contribute to differing responses of serum cholesterol to dairy intake among healthy adults.

  4. Review: DHCR7 activity should be considered during drug development and prenatal toxicity assessment.

  5. In this study, we demonstrate that the prevalent c.964-1G>C Dhcr7 mutation perturbs SMO cilia localization and SHH (Montrer SHH Anticorps) pathway activation as a consequence of reduced cholesterol biosynthesis

  6. these findings highlight DHCR7 as an important regulatory switch between cholesterol and vitamin D synthesis.

  7. The aim of this study was to investigate the association of three polymorphisms in the GC gene (rs7041 and rs4588) and CYP2R1 (Montrer CYP2R1 Anticorps) gene (rs10741657) on 25-(OH) VD serum concentration among Jordanians.

  8. This study shows that Smith-Lemli-Opitz Syndrome patients who are heterozygous/homozygous for one pathogenic mutation and only one parent carrying that mutation are candidates for DHCR7 gene (partial) deletions.

  9. Polymorphisms in CYP2R1 (Montrer CYP2R1 Anticorps)-rs10766197 and DHCR7/NADSYN1 (Montrer NADSYN1 Anticorps)-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations

  10. physical and functional interaction between DHCR24 (Montrer DHCR24 Anticorps) and DHCR7

DHCR7 profil antigène

Profil protéine

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS)\; a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by mental retardation, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Gene names and symbols associated with DHCR7

  • 7-dehydrocholesterol reductase (DHCR7) anticorps
  • 7-dehydrocholesterol reductase (dhcr7) anticorps
  • 7-dehydrocholesterol reductase (DWF5) anticorps
  • 7-dehydrocholesterol reductase (PAAG_04766) anticorps
  • 7-dehydrocholesterol reductase (PITG_13128) anticorps
  • 7-dehydrocholesterol reductase (VDBG_05423) anticorps
  • 7-dehydrocholesterol reductase (MGYG_00712) anticorps
  • 7-dehydrocholesterol reductase (TERG_00580) anticorps
  • 7-dehydrocholesterol reductase (Dhcr7) anticorps
  • 7-Dhcr anticorps
  • 7-STEROL DELTA7 REDUCTASE anticorps
  • 7RED anticorps
  • AA409147 anticorps
  • DELTA5 anticorps
  • DKFZp468C1911 anticorps
  • DWARF 5 anticorps
  • F11F12.21 anticorps
  • F11F12_21 anticorps
  • LE anticorps
  • LEPIDA anticorps
  • MGC64361 anticorps
  • PA anticorps
  • PARVA anticorps
  • SLOS anticorps
  • ST7R anticorps
  • STEROL DELTA7 REDUCTASE anticorps
  • xdhcr7 anticorps

Protein level used designations for DHCR7

7-DHC reductase , sterol Delta(7)-reductase , 7-dehydrocholesterol reductase , delta-7-dehydrocholesterol reductase , putative sterol reductase SR-2 , sterol delta-7-reductase

GENE ID SPECIES
100061433 Equus caballus
378446 Danio rerio
380248 Xenopus laevis
394844 Xenopus (Silurana) tropicalis
841465 Arabidopsis thaliana
9096525 Paracoccidioides sp. 'lutzii' Pb01
9472946 Phytophthora infestans T30-4
9531294 Verticillium alfalfae VaMs.102
10031944 Arthroderma gypseum CBS 118893
10374056 Trichophyton rubrum CBS 118892
100172090 Pongo abelii
13360 Mus musculus
64191 Rattus norvegicus
1717 Homo sapiens
422982 Gallus gallus
483675 Canis lupus familiaris
514745 Bos taurus
379273 Xenopus laevis
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