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anti-APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) Anticorps

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. De plus, nous expédions APEX2 Protéines (3) et APEX2 Kits (2) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
APEX2 27301 Q9UBZ4
APEX2 289662  
APEX2 77622 Q68G58
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Top anti-APEX2 Anticorps sur anticorps-enligne.fr

Showing 10 out of 59 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué FACS, IF, IHC (p), WB Western blot analysis of APEX2 Antibody (Center) (ABIN652924) in MCF-7 cell line lysates (35 µg/lane). APEX2 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with APEX2 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Lapin Inconjugué WB Western Blot: APEX2 Antibody [ABIN42810615] - Western blot analysis of APEXL2 in HeLa cell lysates using ABIN42810615 at a dilution of 1:500. 0.2 mL Connectez-vous pour afficher 3 to 5 Days
302,50 €
Détails
Humain Lapin Inconjugué IHC (p), WB 50 μL Connectez-vous pour afficher 8 to 10 Days
517,00 €
Détails
Humain Lapin Inconjugué IHC (p), WB Anti- APEX2 antibody, Western blotting All lanes: Anti APEX2  at 0.5ug/ml WB: SMMC Whole Cell Lysate at 40ug Predicted bind size: 57KD Observed bind size: 57KD Anti- APEX2 antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Connectez-vous pour afficher 8 to 11 Days
298,57 €
Détails
Boeuf (Vache) Lapin Inconjugué IHC (p), WB Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Connectez-vous pour afficher 11 to 14 Days
501,70 €
Détails
Rat Lapin Inconjugué WB   100 μg Connectez-vous pour afficher 8 to 11 Days
340,48 €
Détails
Humain Lapin Inconjugué IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti-APEX2 Polyclonal Antibody, Unconjugated (ABIN718481) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Connectez-vous pour afficher 9 to 12 Days
304,36 €
Détails
Humain Lapin Inconjugué WB APEXL2 pAb tested by Western blot. APEXL2 detection by Western blot. The analysis of APEXL2 was performed using HeLa whole-cell extract and APEXL2 pAb at a 1:500 dilution. 200 μL Connectez-vous pour afficher 1 to 3 Days
497,22 €
Détails
Boeuf (Vache) Lapin Inconjugué IHC (p), WB   100 μg Connectez-vous pour afficher 11 to 14 Days
548,26 €
Détails
Humain Lapin APC IHC, ELISA, WB   200 μL Connectez-vous pour afficher 11 to 14 Days
1.150,64 €
Détails

APEX2 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-APEX2 Anticorps mieux référencés

  1. Human Polyclonal APEX2 Primary Antibody pour FACS, IF - ABIN652924 : Hadi, Ginalski, Nguyen, Wilson: Determinants in nuclease specificity of Ape1 and Ape2, human homologues of Escherichia coli exonuclease III. dans Journal of molecular biology 2002 (PubMed)

  2. Human Polyclonal APEX2 Primary Antibody pour WB - ABIN4281061 : Karkhanis, Wang, Tae, Hu, Imbalzano, Sif: Protein arginine methyltransferase 7 regulates cellular response to DNA damage by methylating promoter histones H2A and H4 of the polymerase δ catalytic subunit gene, POLD1. dans The Journal of biological chemistry 2012 (PubMed)

Plus d’anticorps contre APEX2 partenaires d’interaction

Xenopus laevis APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. APE2 associates with Chk1 (Montrer CHEK1 Anticorps); a serine residue (S86) in the Chk1 (Montrer CHEK1 Anticorps)-binding motif of APE2 is essential for Chk1 (Montrer CHEK1 Anticorps) phosphorylation, indicating a Claspin (Montrer CLSPN Anticorps)-like but distinct role for APE2 in ATR (Montrer ATR Anticorps)-Chk1 (Montrer CHEK1 Anticorps) signaling.

Human APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. Determinants in nuclease (Montrer DCLRE1C Anticorps) specificity of Ape1 (Montrer APEX1 Anticorps) and Ape2, human homologues of Escherichia coli exonuclease (Montrer EXO1 Anticorps) III

  2. Ape2 exhibits strong 3'-5' exonuclease and 3'-phosphodiesterase activities and has only a very weak AP-endonuclease activity.

  3. Ape2 may be involved in repair of oxidative DNA damage and PCNA (Montrer PCNA Anticorps)-dependent repair synthesis.

Mouse (Murine) APEX Nuclease (Apurinic/apyrimidinic Endonuclease) 2 (APEX2) interaction partners

  1. expression of Apex 2 in chondrocytes appears to be associated with the degeneration of articular cartilage in osteoarthritis.

  2. Results indicate a role for apurinic/apyrimidinic endonuclease (APE (Montrer RPLP0 Anticorps)) 2 (Apex2) in the protection of germinal center (GC) cells from activation-induced cytidine deaminase (Montrer AICDA Anticorps) (AID)-independent damage.

  3. data provide new insight into error-prone repair of AID-induced lesions, which we propose is facilitated by down-regulation of APE1 (Montrer APEX1 Anticorps) and up-regulation of APE2 expression in germinal center B cells.

  4. Extensive analysis of bone marrow hematopoiesis in APE2-deficient mice finds inhibition of the pro-B to pre-B lymphocyte (Montrer AKAP17A Anticorps) transition, due to a p53 (Montrer TP53 Anticorps)-dependent DNA damage response, independent from its ubiquitous and essential homolog APE1 (Montrer APEX1 Anticorps).

  5. APEX2 is required for proper cell cycle progression of proliferating lymphocytes.

  6. Both APE1 (Montrer APEX1 Anticorps) and APE2 function in antibody switch recomibination, resulting in double stranded breaks necesary for this recombination.

  7. The present study clearly demonstrates that APEX2-null lymphocytes have a higher frequency of DNA breaks, indicating that APEX2 may play an important role(s) during their generation and/or repair.

  8. Apex2 is required for efficient somatic hypermutation of immunoglobulin genes.

APEX2 profil antigène

Profil protéine

Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene names and symbols associated with APEX2

  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (apex2) anticorps
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2 (APEX2) anticorps
  • APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1 (Apex2l1) anticorps
  • apurinic/apyrimidinic endonuclease 2 (Apex2) anticorps
  • APE2 anticorps
  • APEXL2 anticorps
  • C430040P13Rik anticorps
  • XTH2 anticorps
  • zgc:55889 anticorps

Protein level used designations for APEX2

DNA-(apurinic or apyrimidinic site) lyase 2 , APEX nuclease (apurinic/apyrimidinic endonuclease) 2 , DNA-(apurinic or apyrimidinic site) lyase 2-like , AP endonuclease 2 , AP endonuclease XTH2 , apurinic/apyrimidinic endonuclease-like 2 , APEX nuclease 2 , apurinic-apyrimidinic endonuclease 2

GENE ID SPECIES
448512 Xenopus (Silurana) tropicalis
393115 Danio rerio
446614 Xenopus laevis
702084 Macaca mulatta
100410557 Callithrix jacchus
100434759 Pongo abelii
27301 Homo sapiens
491499 Canis lupus familiaris
511790 Bos taurus
289662 Rattus norvegicus
77622 Mus musculus
Fournisseurs de qualité sélectionnés pour anti-APEX2 (APEX2) Anticorps
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