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The protein encoded by ABHD5 belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. De plus, nous expédions ABHD5 Protéines (9) et ABHD5 Kits (7) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 77 products:
Human Polyclonal ABHD5 Primary Antibody pour SimWes, WB - ABIN258372
Yamaguchi, Omatsu, Matsushita, Osumi: CGI-58 interacts with perilipin and is localized to lipid droplets. Possible involvement of CGI-58 mislocalization in Chanarin-Dorfman syndrome. dans The Journal of biological chemistry 2004
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Human Monoclonal ABHD5 Primary Antibody pour IHC (p), ELISA - ABIN565526
Kinney, Qiao, Levaugh, Shao: B56alpha/protein phosphatase 2A inhibits adipose lipolysis in high-fat diet-induced obese mice. dans Endocrinology 2010
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Human Monoclonal ABHD5 Primary Antibody pour ELISA, WB - ABIN565527
Watt, van Denderen, Castelli, Bruce, Hoy, Kraegen, Macaulay, Kemp: Adipose triglyceride lipase regulation of skeletal muscle lipid metabolism and insulin responsiveness. dans Molecular endocrinology (Baltimore, Md.) 2008
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Polyclonal ABHD5 Primary Antibody pour WB - ABIN540799
Subramanian, Rothenberg, Gomez, Cohen, Garcia, Bhattacharyya, Shapiro, Dolios, Wang, Lisanti, Brasaemle: Perilipin A mediates the reversible binding of CGI-58 to lipid droplets in 3T3-L1 adipocytes. dans The Journal of biological chemistry 2004
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Cow (Bovine) Polyclonal ABHD5 Primary Antibody pour ICC, IF - ABIN252915
Sitnick, Basantani, Cai, Schoiswohl, Yazbeck, Distefano, Ritov, DeLany, Schreiber, Stolz, Gardner, Kienesberger, Pulinilkunnil, Zechner, Goodpaster, Coen, Kershaw: Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity. dans Diabetes 2013
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Human Polyclonal ABHD5 Primary Antibody pour ELISA, WB - ABIN190850
Lass, Zimmermann, Haemmerle, Riederer, Schoiswohl, Schweiger, Kienesberger, Strauss, Gorkiewicz, Zechner: Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome. dans Cell metabolism 2006
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ABHD5 possesses a PNPLA2 (Montrer PNPLA2 Anticorps)-independent function in regulating autophagy and tumorigenesis.
These results indicate that HCV taps (Montrer ASPRV1 Anticorps) into the lipid droplet triglyceride reservoir usurping ABHD5 lipase (Montrer LIPG Anticorps) cofactor function
Case Report: novel ABHD5 mutation, c.838C > T (p.Arg280*), in trans with p.Arg234* in a Chinese patient with very mild Dorfman-Chanarin syndrome.
Authors show that rat ATGL (Montrer PNPLA2 Anticorps), coactivated by rat CGI-58, efficiently hydrolyzes triglycerides and retinyl ester.
novel ABHD5 truncating variant in a twenty nine month old female child, who presented with icthyosiform erythroderma.
simultaneous tryptophan alanine permutations in both arms abolish localization and activity of CGI-58 as opposed to tryptophan substitutions that occur in only one arm.
this study presents clinical and molecular data of four affected relatives with Chanarin-Dorfman syndrome homozygous for a N209X mutation in ABHD5, and provides a short review by comparing patients with N209X homozygous mutations to patients with other ABHD5 mutations.
PLIN5 (Montrer PLIN5 Anticorps) was significantly colocated with ATGL (Montrer PNPLA2 Anticorps), mitochondria and CGI-58, indicating a close association between the key lipolytic effectors in resting skeletal muscle.
-mediated phosphorylation of CGI-58 is required for dispersion of CGI-58 from perilipin (Montrer PLIN1 Anticorps) 1A-coated lipid droplets
Abhd5 expression falls substantially and correlates negatively with malignant features in human colorectal cancer.
omega-O-AcylCer and CLE (Montrer C14orf166 Anticorps) formation critically depend on CGI-58 expression in differentiated keratinocytes.
These results demonstrate that macrophage CGI-58 enhances PPAR-gamma (Montrer PPARG Anticorps) signaling and thus suppresses inflammatory responsiveness and mitochondrial dysfunction in macrophages.
Here, we identify synthetic ligands that release ABHD5 from PLIN1 (Montrer PLIN1 Anticorps) or PLIN5 (Montrer PLIN5 Anticorps) without PKA activation and rapidly activate adipocyte and muscle lipolysis.
we identify adipocyte-type fatty acid-binding protein (A-Fabp (Montrer FABP4 Anticorps)) and other members of the fatty acid-binding protein (Fabp (Montrer FABP Anticorps)) family as interaction partners of Cgi-58.
Data (including data from studies in atherosclerotic knockout mice) suggest CGI58-deficient macrophages store-up triglyceride-rich droplets and have reduced phagocytic capacity, comparable to Atgl- (adipose triglyceride lipase (Montrer PNPLA2 Anticorps)-)deficient macrophages.
Muscle CGI-58 deficiency causes cardiac dysfunction and fat deposition in oxidative muscles but induces a series of favorable metabolic changes in mice fed a high-fat diet.
intestinal CGI-58 is required for efficient postprandial lipoprotein-TG secretion and for maintaining hepatic and plasma lipid homeostasis.
CGI-58 transgenic/ApoE (Montrer APOE Anticorps)-/- mice exhibited an anti-atherosclerosis phenotype compared with wild type (WT) controls (CGI-58 WT/ApoE (Montrer APOE Anticorps)-/-), illustrated by less plaque area in aortic roots.
These findings suggest that CGI-58 may be a new target for enhancing the quality of pork products as well as offering the potential of CGI-58 for human obesity treatment.
The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.
abhydrolase domain containing 5
, CGI58 protein
, 1-acylglycerol-3-phosphate O-acyltransferase ABHD5
, abhydrolase domain-containing protein 5
, lipid droplet-binding protein CGI-58
, alpha/beta hydrolase domain-containing 5
, lipid droplet binding protein
, Abhydrolase domain-containing protein 5