You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Anticorps

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. De plus, nous expédions Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Protéines (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
APPL1 26060 Q9UKG1
APPL1 72993 Q8K3H0
APPL1 290537  
Comment commander chez anticorps-enligne
  • +33 (0)1 76 63 32 65
  • +33 (0)1 74 18 08 22
  • Commandez enligne
  • orders@anticorps-enligne.fr

Top anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 64 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB WB Suggested Anti-APPL1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500Positive Control: THP-1 cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Boeuf (Vache) Chèvre Inconjugué WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Chèvre Inconjugué ELISA, WB ABIN190879 (0.5µg/ml) staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL1 adenovirus for 48hrs. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: APPL1 Antibody [ABIN252906] - APPL1 expression level after adenovirus transfection in rat aortic smooth muscle cells detected by ABIN252906. Western Blot: APPL Antibody [ABIN2529061] - Staining of 1) Rat Aortic Smooth Muscle cell lysate 2) after infection with Human APPL adenovirus for 48hrs using ABIN2529061 at 0.5ug/ml. Detected by chemiluminescence. Data kindly provided by Dr. L. Jia, Ann Arbor, USA. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Souris Lapin Inconjugué ICC, IF, IHC (p), IP, WB 50 μL Connectez-vous pour afficher 3 to 4 Days
437,80 €
Détails
Humain Lapin Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 6 to 8 Days
342,86 €
Détails
Humain Lapin Inconjugué ELISA, WB 100 μL Connectez-vous pour afficher 13 Days
154,33 €
Détails
Humain Lapin Inconjugué IHC (p), WB Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Connectez-vous pour afficher 11 to 14 Days
801,43 €
Détails
Humain Lapin Inconjugué IHC (p), WB Anti-APPL antibody, Western blotting WB: HELA Cell Lysate 100 μg Connectez-vous pour afficher 8 to 11 Days
298,57 €
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB Immunohistochemistry-Paraffin: APPL Antibody [NBP2-15434] - Paraffin-embedded AZ521 xenograft, using antibody at 1:100 dilution. Western Blot: APPL Antibody [NBP2-15434] - Sample (30 ug of whole cell lysate) A: MCF-7 7.5% SDS PAGE; antibody diluted at 1:1000. 0.1 mL Connectez-vous pour afficher 4 to 7 Days
426,25 €
Détails

APPL1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Human , ,
, ,
,
, , , , ,
Mouse (Murine)
,
,
Rat (Rattus)
,
,

anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Anticorps mieux référencés

  1. Mouse (Murine) Monoclonal APPL1 Primary Antibody pour ICC, IF - ABIN1042584 : Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. dans Oncogene 1999 (PubMed)
    Show all 5 references for ABIN1042584

  2. Cow (Bovine) Polyclonal APPL1 Primary Antibody pour WB - ABIN374837 : Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. dans Nature cell biology 2006 (PubMed)

  3. Human Polyclonal APPL1 Primary Antibody pour WB - ABIN2785912 : McCrea, Paradise, Tomasini, Addis, Melis, De Matteis, De Camilli: All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding. dans Biochemical and biophysical research communications 2008 (PubMed)

  4. Human Polyclonal APPL1 Primary Antibody pour ELISA, WB - ABIN1451205 : Matsuoka, Ballif, Smogorzewska, McDonald, Hurov, Luo, Bakalarski, Zhao, Solimini, Lerenthal, Shiloh, Gygi, Elledge: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. dans Science (New York, N.Y.) 2007 (PubMed)

Plus d’anticorps contre Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 partenaires d’interaction

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Results indicate that persistent rab5 (Montrer RAB5A Anticorps) overactivation through beta-cleaved carboxy-terminal fragment of APP (Montrer APP Anticorps)-APPL1 interactions constitutes a novel APP (Montrer APP Anticorps)-dependent pathogenic pathway in Alzheimer's disease

  2. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  3. Low expression of APPL1 is associated with metastasis in prostate cancer.

  4. APPL1 endosomes represent a distinct population of Rab5 (Montrer RAB5A Anticorps)-positive sorting endosomes.

  5. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (Montrer TSC2 Anticorps)

  6. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  7. A role for APPL1 in TLR3 (Montrer TLR3 Anticorps)/4-dependent TBK1 (Montrer TBK1 Anticorps) and IKKepsilon (Montrer IKBKE Anticorps) activation in macrophages.

  8. ATM (Montrer ATM Anticorps) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

  9. APPL1 sensitizes insulin (Montrer INS Anticorps) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (Montrer INS Anticorps) signaling and crosstalk between the insulin (Montrer INS Anticorps) and adiponectin (Montrer ADIPOQ Anticorps) pathways.

  10. APPL1 is a positive regulator of Dvl2 (Montrer DVL2 Anticorps)-dependent transcriptional activity of AP-1 (Montrer FOSB Anticorps).

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (Montrer HGF Anticorps)-induced Akt (Montrer AKT1 Anticorps) activation, migration, and invasion.

  2. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (Montrer PRKAA1 Anticorps) signaling.

  3. A role for APPL1 in TLR3 (Montrer TLR3 Anticorps)/4-dependent TBK1 (Montrer TBK1 Anticorps) and IKKepsilon (Montrer IKBKE Anticorps) activation in macrophages.

  4. APPL1 sensitizes insulin (Montrer INS Anticorps) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (Montrer INS Anticorps) signaling and crosstalk between the insulin (Montrer INS Anticorps) and adiponectin (Montrer ADIPOQ Anticorps) pathways.

  5. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  6. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (Montrer INS Anticorps) sensitivity.

  7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (Montrer INS Anticorps) resistance and improves adipoR1 (Montrer ADIPOR1 Anticorps)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  8. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (Montrer AKT1 Anticorps) cascade in neurons.

  9. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (Montrer INS Anticorps) resistance to beta-cell dysfunction in type 2 diabetes.

  10. Endurance training was able to increase APPL1 expression.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) profil antigène

Profil protéine

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) anticorps
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) anticorps
  • 2900057D21Rik anticorps
  • 7330406P05Rik anticorps
  • AI585782 anticorps
  • APPL anticorps
  • AW209077 anticorps
  • BB022931 anticorps
  • C88264 anticorps
  • DIP13 anticorps
  • DIP13alpha anticorps
  • RGD1309388 anticorps

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
Fournisseurs de qualité sélectionnés pour anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Anticorps
Avez-vous cherché autre chose?