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The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. De plus, nous expédions Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Mouse (Murine) Monoclonal APPL1 Primary Antibody pour ICC, IF - ABIN1042584
Mitsuuchi, Johnson, Sonoda, Tanno, Golemis, Testa: Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2. dans Oncogene 1999
Show all 5 Pubmed References
Human Polyclonal APPL1 Primary Antibody pour ELISA, WB - ABIN252906
Mao, Kikani, Riojas, Langlais, Wang, Ramos, Fang, Christ-Roberts, Hong, Kim, Liu, Dong: APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. dans Nature cell biology 2006
APPL1 positively mediated leptin (Montrer LEP Anticorps) signaling.
Decreased expression of APPL1 is associated with polycystic ovary syndrome.
Results indicate that persistent rab5 (Montrer RAB5A Anticorps) overactivation through beta-cleaved carboxy-terminal fragment of APP (Montrer APP Anticorps)-APPL1 interactions constitutes a novel APP (Montrer APP Anticorps)-dependent pathogenic pathway in Alzheimer's disease
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
Low expression of APPL1 is associated with metastasis in prostate cancer.
APPL1 endosomes represent a distinct population of Rab5 (Montrer RAB5A Anticorps)-positive sorting endosomes.
article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (Montrer TSC2 Anticorps)
Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.
A role for APPL1 in TLR3 (Montrer TLR3 Anticorps)/4-dependent TBK1 (Montrer TBK1 Anticorps) and IKKepsilon (Montrer IKBKE Anticorps) activation in macrophages.
ATM (Montrer ATM Anticorps) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.
Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (Montrer TLR4 Anticorps)-induced signaling, transcription, and cytokine secretion.
Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (Montrer HGF Anticorps)-induced Akt (Montrer AKT1 Anticorps) activation, migration, and invasion.
In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (Montrer PRKAA1 Anticorps) signaling.
APPL1 sensitizes insulin (Montrer INS Anticorps) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (Montrer INS Anticorps) signaling and crosstalk between the insulin (Montrer INS Anticorps) and adiponectin (Montrer ADIPOQ Anticorps) pathways.
Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.
APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (Montrer INS Anticorps) sensitivity.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (Montrer INS Anticorps) resistance and improves adipoR1 (Montrer ADIPOR1 Anticorps)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue
APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (Montrer AKT1 Anticorps) cascade in neurons.
Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (Montrer INS Anticorps) resistance to beta-cell dysfunction in type 2 diabetes.
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
, DCC-interacting protein 13-alpha
, adapter protein containing PH domain, PTB domain and leucine zipper motif 1
, adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
, signaling adaptor protein DIP13alpha
, DIP13 alpha
, adaptor protein APPL like