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The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. De plus, nous expédions Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Anticorps (69) et Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Protéines (5) et beaucoup plus de produits pour cette protéine.
APPL1 positively mediated leptin (Montrer LEP Kits ELISA) signaling.
Decreased expression of APPL1 is associated with polycystic ovary syndrome.
Results indicate that persistent rab5 (Montrer RAB5A Kits ELISA) overactivation through beta-cleaved carboxy-terminal fragment of APP (Montrer APP Kits ELISA)-APPL1 interactions constitutes a novel APP (Montrer APP Kits ELISA)-dependent pathogenic pathway in Alzheimer's disease
Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.
Low expression of APPL1 is associated with metastasis in prostate cancer.
APPL1 endosomes represent a distinct population of Rab5 (Montrer RAB5A Kits ELISA)-positive sorting endosomes.
article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (Montrer TSC2 Kits ELISA)
Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.
A role for APPL1 in TLR3 (Montrer TLR3 Kits ELISA)/4-dependent TBK1 (Montrer TBK1 Kits ELISA) and IKKepsilon (Montrer IKBKE Kits ELISA) activation in macrophages.
ATM (Montrer ATM Kits ELISA) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.
APPL1-SirT1 (Montrer SIRT1 Kits ELISA)-STAT3 (Montrer STAT3 Kits ELISA) pathway mediated adiponectin (Montrer ADIPOQ Kits ELISA) signaling in primary hepatocytes.
Here we establish potential roles for APPL1 and 2 signaling adaptors as regulators of LPS/TLR4 (Montrer TLR4 Kits ELISA)-induced signaling, transcription, and cytokine secretion.
Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (Montrer HGF Kits ELISA)-induced Akt (Montrer AKT1 Kits ELISA) activation, migration, and invasion.
In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (Montrer PRKAA1 Kits ELISA) signaling.
APPL1 sensitizes insulin (Montrer INS Kits ELISA) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (Montrer INS Kits ELISA) signaling and crosstalk between the insulin (Montrer INS Kits ELISA) and adiponectin (Montrer ADIPOQ Kits ELISA) pathways.
Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.
APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (Montrer INS Kits ELISA) sensitivity.
Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (Montrer INS Kits ELISA) resistance and improves adipoR1 (Montrer ADIPOR1 Kits ELISA)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue
APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (Montrer AKT1 Kits ELISA) cascade in neurons.
The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.
, DCC-interacting protein 13-alpha
, adapter protein containing PH domain, PTB domain and leucine zipper motif 1
, adaptor protein containing pH domain, PTB domain and leucine zipper motif 1
, signaling adaptor protein DIP13alpha
, DIP13 alpha
, adaptor protein APPL like