Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) Kits ELISA

The protein encoded by APPL1 has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. De plus, nous expédions Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Anticorps (65) et Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 Protéines (5) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain APPL1 APPL1 26060 Q9UKG1
Anti-Souris APPL1 APPL1 72993 Q8K3H0
Anti-Rat APPL1 APPL1 290537  
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Plus Kits ELISA pour Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 partenaires d'interaction

Human Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. APPL1 positively mediated leptin (Montrer LEP Kits ELISA) signaling.

  2. Decreased expression of APPL1 is associated with polycystic ovary syndrome.

  3. Results indicate that persistent rab5 (Montrer RAB5A Kits ELISA) overactivation through beta-cleaved carboxy-terminal fragment of APP (Montrer APP Kits ELISA)-APPL1 interactions constitutes a novel APP (Montrer APP Kits ELISA)-dependent pathogenic pathway in Alzheimer's disease

  4. Data show that signal transducing adaptor proteins APPL1 and APPL2 are required for TGFbeta-induced nuclear translocation of TGFbeta type I receptor (TbetaRI)-ICD and for cancer cell invasiveness of prostate and breast cancer cell lines.

  5. Low expression of APPL1 is associated with metastasis in prostate cancer.

  6. APPL1 endosomes represent a distinct population of Rab5 (Montrer RAB5A Kits ELISA)-positive sorting endosomes.

  7. article provides evidence that GG genotype and G carrier (CG+GG) genotypes of the rs4640525 polymorphism in the APPL1 gene may be suitable susceptibility biomarkers for NAFLD (Montrer TSC2 Kits ELISA)

  8. Two loss-of-function mutations in APPL1, identified by means of whole-exome sequencing, found in two large families with a high prevalence of Familial Diabetes Mellitus.

  9. A role for APPL1 in TLR3 (Montrer TLR3 Kits ELISA)/4-dependent TBK1 (Montrer TBK1 Kits ELISA) and IKKepsilon (Montrer IKBKE Kits ELISA) activation in macrophages.

  10. ATM (Montrer ATM Kits ELISA) is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair.

Mouse (Murine) Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) interaction partners

  1. Appl1/2-null mouse embryonic fibroblasts exhibited defects in HGF (Montrer HGF Kits ELISA)-induced Akt (Montrer AKT1 Kits ELISA) activation, migration, and invasion.

  2. In experimental high glucose condition APPL1 acts as a protective factor against podocytes injury through regulating AMPK (Montrer PRKAA1 Kits ELISA) signaling.

  3. A role for APPL1 in TLR3 (Montrer TLR3 Kits ELISA)/4-dependent TBK1 (Montrer TBK1 Kits ELISA) and IKKepsilon (Montrer IKBKE Kits ELISA) activation in macrophages.

  4. APPL1 sensitizes insulin (Montrer INS Kits ELISA) signaling by acting at a site downstream of the IR. Study uncovers a mechanism regulating insulin (Montrer INS Kits ELISA) signaling and crosstalk between the insulin (Montrer INS Kits ELISA) and adiponectin (Montrer ADIPOQ Kits ELISA) pathways.

  5. Study demonstrates the roles of APPL1 in regulating GSIS and mitochondrial function in pancreatic beta cells, which implicates APPL1 as a therapeutic target in the treatment of type 2 diabetes.

  6. APPL1 transgenic mice exhibit improved peripheral metabolism, reduced cardiac lipotoxicity, and improved insulin (Montrer INS Kits ELISA) sensitivity.

  7. Our findings demonstrate that exercise training performed concomitantly to a high-fat diet reduces the degree of insulin (Montrer INS Kits ELISA) resistance and improves adipoR1 (Montrer ADIPOR1 Kits ELISA)-2/APPL1 protein levels in the hepatic, adipose, and skeletal muscle tissue

  8. APPL1 contributes to connecting synaptic NMDA receptors with the intracellular phosphoinositide 3-kinase /Akt (Montrer AKT1 Kits ELISA) cascade in neurons.

  9. Reduced APPL1 expression in pancreatic islets may serve as a pathological link that couples insulin (Montrer INS Kits ELISA) resistance to beta-cell dysfunction in type 2 diabetes.

  10. Endurance training was able to increase APPL1 expression.

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) profil antigène

Antigen Summary

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

Gene names and symbols associated with APPL1

  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (APPL1) anticorps
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 (Appl1) anticorps
  • 2900057D21Rik anticorps
  • 7330406P05Rik anticorps
  • AI585782 anticorps
  • APPL anticorps
  • AW209077 anticorps
  • BB022931 anticorps
  • C88264 anticorps
  • DIP13 anticorps
  • DIP13alpha anticorps
  • RGD1309388 anticorps

Protein level used designations for APPL1

AKT2 interactor , DCC-interacting protein 13-alpha , adapter protein containing PH domain, PTB domain and leucine zipper motif 1 , adaptor protein containing pH domain, PTB domain and leucine zipper motif 1 , dip13-alpha , signaling adaptor protein DIP13alpha , DIP13 alpha , adaptor protein APPL like

GENE ID SPECIES
100058653 Equus caballus
26060 Homo sapiens
484716 Canis lupus familiaris
517850 Bos taurus
72993 Mus musculus
290537 Rattus norvegicus
100188978 Sus scrofa
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