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BCAM encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. De plus, nous expédions BCAM Kits (15) et BCAM Protéines (13) et beaucoup plus de produits pour cette protéine.
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Human Monoclonal BCAM Primary Antibody pour ELISA (Capture), FACS - ABIN4900214
Kikkawa, Miwa, Tohara, Hamakubo, Nomizu: An antibody to the lutheran glycoprotein (Lu) recognizing the LU4 blood type variant inhibits cell adhesion to laminin α5. dans PLoS ONE 2011
Lu/BCAM may have a critical role in facilitating the accumulation of monocytes and macrophages, thereby exacerbating renal injury in crescentic glomerulonephritis.
Lutheran (Lu), also known as basal cell adhesion molecule (B-CAM), competes with integrins for binding to laminin alpha5, a subunit of LM-511, a major component of basement membranes.
Lu/BCAM, as a laminin receptor, is involved in vivo in the maintenance of normal basement membrane organization in the kidney and intestine.
Cytometry analysis evidenced a specific expression profile on reticulocytes of SCA infants, with notably an increased expression of the adhesion molecules Lu/BCAM, ICAM-4 (Montrer ICAM4 Anticorps) and LFA-3, both in percentage of positive cells and in surface density.
Through molecular genotyping we also identified polymorphisms in RhCE (Montrer RHCE Anticorps), Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.
The variable levels of expression of mutated JAK2 (Montrer JAK2 Anticorps) and BCAM (Montrer BCAT2 Anticorps) proteins determine different adhesion patterns of erythrocytes from polycythemia vera (Montrer IGF2BP3 Anticorps) patients.
These studies revealed amino acids 720 to 1014 of CNF1 as the binding site for Lu/BCAM.
High BCAM (Montrer BCAT2 Anticorps) expression is associated with hepatocellular carcinoma.
Adhesion of sickle reticulocytes to HC-treated endothelial cells was decreased despite the HC-derived increase of Lu/BCAM expression.
tumor cell migration on LM-511 requires that Lu/B-CAM competitively modulates cell attachment through integrins.
DARC (Montrer DARC Anticorps) and BCAM (Montrer BCAT2 Anticorps) expression was associated with pathogenesis of thyroid carcinoma and correlated with clinical-pathological features.
Glu425 in the Lu glycoprotein is required for expression of Lu7, and Ala425 is associated with the LU:-7 phenotype. This completes the molecular basis associated with all antigens known to be in the Lutheran blood group system.
Increases in adhesion frequency provide significant evidence of the role of epinephrine in BCAM/Lu-laminin and ICAM-4 (Montrer ICAM4 Anticorps)-alpha(v)beta(3) bonding, and suggest mechanisms of vaso-occlusion during physical exertion in sickle cell trait.
This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene.
basal cell adhesion molecule (Lutheran blood group)
, Auberger b antigen
, Lutheran blood group
, basal cell adhesion molecule (Lu and Au blood groups)
, basal cell adhesion molecule
, basal cell adhesion molecule-like
, B-CAM cell surface glycoprotein
, lutheran antigen
, lutheran glycoprotein
, B-cell adhesion molecule
, F8/G253 antigen
, antigen identified by monoclonal antibody F8
, glycoprotein 95kDa
, Lutheran blood group (Auberger b antigen included)