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The protein encoded by BMF belongs to the BCL2 protein family. De plus, nous expédions BMF Kits (26) et BMF Protéines (14) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal BMF Primary Antibody pour IHC, WB - ABIN411435
Chen, Huang, Wang: Deficiency of Bim in dendritic cells contributes to overactivation of lymphocytes and autoimmunity. dans Blood 2007
Show all 2 references for 411435
Human Polyclonal BMF Primary Antibody pour WB - ABIN2477675
Puthalakath, Villunger, OReilly, Beaumont, Coultas, Cheney, Huang, Strasser: Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. dans Science (New York, N.Y.) 2001
Human Polyclonal BMF Primary Antibody pour ICC, IF - ABIN4284847
Gramantieri, Fornari, Ferracin, Veronese, Sabbioni, Calin, Grazi, Croce, Bolondi, Negrini: MicroRNA-221 targets Bmf in hepatocellular carcinoma and correlates with tumor multifocality. dans Clinical cancer research : an official journal of the American Association for Cancer Research 2009
Reciprocal regulation of BMF and BIRC5 (Montrer BIRC5 Anticorps) is linked to Eomes (Montrer EOMES Anticorps) overexpression in colorectal cancer.
Early generated B1 B cells with restricted BCRs become chronic lymphocytic leukemia with continued c-Myc (Montrer MYC Anticorps) and low Bmf expression
these findings suggest that p53 (Montrer TP53 Anticorps)-R273H can specifically drive AKT (Montrer AKT1 Anticorps) signaling and suppress BMF expression, resulting in enhanced cell survivability and anoikis resistance.
On the corresponding BMF gene promoter, loss of HDAC8 (Montrer HDAC8 Anticorps) was associated with signal transducer and activator of transcription 3 (STAT3 (Montrer STAT3 Anticorps))/specificity protein 3 (Sp3) transcription factor exchange and recruitment of p300 (Montrer EP300 Anticorps).
Overexpression of ApoL2 (Montrer APOL2 Anticorps) did not induce cell death on its own. ApoL2 (Montrer APOL2 Anticorps) did not sensitize or protect cells from overexpression of the BH3-only (Montrer BBC3 Anticorps) proteins Bmf or Noxa (Montrer PMAIP1 Anticorps).
Diva (Montrer BCL2L10 Anticorps) binds peptides derived from the BH3 domain of several other proapoptotic Bcl-2 (Montrer BCL2 Anticorps) proteins, including mouse Harakiri (Montrer HRK Anticorps), Bid (Montrer BID Anticorps), Bak (Montrer BAK1 Anticorps) and Bmf.
BMF is induced in human IEC by the loss of cell attachment and is likely to play an important role in the regulation of IEC survival
characterization of the bmf gene locus; molecular basis of the generation of the 2 major isoforms of Bmf; provide evidence that Bmf can act as a sensor for stress that associates with the repression of the conventional CAP-dependent translation machinery
Data show that hypoxic conditions inhibit anoikis and block expression of proapoptotic BH3-only (Montrer BBC3 Anticorps) family members Bim (Montrer BCL2L11 Anticorps) and Bmf in epithelial cells.
Bmf is upregulated by PS-341 and has a crucial role in PS-341-mediated glioma cell death through JNK (Montrer MAPK8 Anticorps) phosphorylation.
BMF loss is associated with germ cell loss during oogenesis.
Bcl2 interacting mediator of cell death (Bim (Montrer BCL2L11 Anticorps)) and Bcl2 modifying factor (Bmf), mediate apoptosis in the context of TACI (Montrer TNFRSF13B Anticorps)-Ig overexpression that effectively neutralizes BAFF (Montrer TNFSF13B Anticorps) as well as APRIL.
Bmf deficiency induced significant protection against oxygen/glucose deprivation injury in cultured neurons.
Our findings support an important role for BMF in determining the number of primordial follicles maintained in the ovary throughout adult reproductive life.
Bim (Montrer BCL2L11 Anticorps) and Bmf act in concert to prevent autoimmunity and malignant disease
Bmf-deficient mice showed normal sensitivity to the convulsant effects of KA, displayed significantly more neuronal death in the hippocampal CA1 (Montrer CA1 Anticorps) and CA3 (Montrer CA3 Anticorps) subfields after SE.
deacetylation of p53 (Montrer TP53 Anticorps) suppresses Bmf expression and facilitates autophagy.
critical role for Bim (Montrer BCL2L11 Anticorps) and Bmf as regulators of hematopoietic stem and progenitor cell dynamics both during early engraftment and long-term reconstitution
our study suggests that Bad and Bmf co-regulate lymphocyte homeostasis and limit spontaneous transformation by mechanisms that may not exclusively be linked to the induction of lymphocyte apoptosis.
a potential role for Bmf in regulating renal proximal tubular cells (RPTC) apoptosis and tubular atrophy in diabetes.
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.
Bcl2 modifying factor
, bcl-2-modifying factor
, Bcl-2 modifying factor
, Bcl-2-modifying factor