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CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. De plus, nous expédions CDC20 Protéines (6) et CDC20 Kits (1) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 218 products:
Human Polyclonal CDC20 Primary Antibody pour ICC, IF - ABIN252981
Di Fiore, Pines: How cyclin A destruction escapes the spindle assembly checkpoint. dans The Journal of cell biology 2010
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Human Polyclonal CDC20 Primary Antibody pour ICC, IF - ABIN252980
Ahlskog, Björk, Elsing, Aspelin, Kallio, Roos-Mattjus, Sistonen: Anaphase-promoting complex/cyclosome participates in the acute response to protein-damaging stress. dans Molecular and cellular biology 2010
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Xenopus laevis Monoclonal CDC20 Primary Antibody pour CyTOF, ELISA - ABIN251088
Sackton, Dimova, Zeng, Tian, Zhang, Sackton, Meaders, Pfaff, Sigoillot, Yu, Luo, King: Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. dans Nature 2014
Human Polyclonal CDC20 Primary Antibody pour IP, WB - ABIN233786
Yamamuro, Kano, Naito: Functions of FZR1 and CDC20, activators of the anaphase-promoting complex, during meiotic maturation of swine oocytes. dans Biology of reproduction 2008
Human Polyclonal CDC20 Primary Antibody pour IHC, IHC (p) - ABIN4296835
Onul, Colvard, Paradise, Elseth, Vesper, Gouvas, Deliu, Garcia, Pestle, Radosevich: Application of immunohistochemical staining to detect antigen destruction as a measure of tissue damage. dans The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012
The ABBA (Montrer MTSS1L Anticorps)-KEN (Montrer PCNT Anticorps)-ABBA (Montrer MTSS1L Anticorps) amino acid motif cassette holds the Mitotic Checkpoint (Montrer BUB3 Anticorps) Complex (MCC (Montrer MCC Anticorps)) onto the Anaphase-Promoting Complex-Cyclosome (APC (Montrer APC Anticorps)/C) by binding the two Cdc20 molecules in the MCC (Montrer MCC Anticorps)-APC (Montrer APC Anticorps)/C complex.
It discuses the roles of Cdc20 in SAC (Montrer ADCY10 Anticorps) signalling and mitotic exit, describe how the integration of traditional approaches with emerging technologies has revealed new details of Cdc20 functions, comment about the potential of Cdc20 as a therapeutic target for the treatment of human malignancies.
Prostate cancer-derived SPOP (Montrer SPOP Anticorps) mutants failed to interact with Cdc20 to promote its degradation. As a result, SPOP (Montrer SPOP Anticorps)-deficient prostate cancer cells with elevated Cdc20 expression became resistant to a pharmacological Cdc20 inhibitor.
High CDC20 expression is associated with metastatic castration-resistant prostate cancer growth and reduces chemosensitivity .
These results provide novel insight into the mechanisms underlying the aberrant capability of NUP98 (Montrer NUP98 Anticorps) oncoproteins to interact with APC (Montrer APC Anticorps)/C(Cdc20) and to interfere with its function.
In lung adenocarcinoma patients, overexpression of cell division cycle 20 was significantly associated with bigger primary tumor size, higher MKI67 (Montrer MKI67 Anticorps) level, higher DNA ploidy level, and poor prognosis.
CDC20 may have a role in carcinoma of the breast, colon, endometrium, and prostate
Overexpression of Cdc20 may serve as an independent predictor for biochemical recurrence in patients of clinically localized prostate cancer undergoing laparoscopic radical prostatectomy without neoadjuvant therapy.
Results show that CYP1B1 (Montrer CYP1B1 Anticorps) may promote renal cell carcinoma (Montrer MOK Anticorps) development by inducing CDC20 expression and inhibiting apoptosis through the down-regulation of DAPK1 (Montrer DAPK1 Anticorps).
Study describes a positive feedback loop centred on cyclin A2 (Montrer CCNA2 Anticorps)-Cdk2 (Montrer CDK2 Anticorps) inhibition of interphase APC (Montrer APC Anticorps)/C-Cdc20 to allow further cyclin A2 (Montrer CCNA2 Anticorps) accumulation and mitotic entry.
Cdc20 auto-ubiquitylation does not play a major role in terminating Cdc20 activation.
Dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase.
A role for the fizzy/cdc20 family of proteins in activation of the APC (Montrer APC Anticorps)/C distinct from substrate recruitment is reported.
Cdc20 hypomorphism causes chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome-microtubule attachment.
The physiologically effective threshold level of Cdc20 is high for female meiosis I.
Results indicate that Cdc20 also contributes to post-anaphase activation of the APC (Montrer APC Anticorps)/C.
The seven tandem WD motifs of Cdc20 they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells
Data suggest that Mad2 (Montrer MXI1 Anticorps) and BubR1 (Montrer BUB1B Anticorps) must cooperate to inhibit Cdc20 activity.
Cdc20 is degraded through two independent degradation signals (degrons), the KEN (Montrer PCNT Anticorps) box and a newly described CRY (Montrer CRY2 Anticorps) box.
Cdc20 and securin (Montrer PTTG1 Anticorps) double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin (Montrer PTTG1 Anticorps) in preventing mitotic exit
Expression of the cdc20 gene is down-regulated by zif268 (Montrer EGR1 Anticorps) in neuronal cells; altered expression of proteasome-regulatory genes following zif268 (Montrer EGR1 Anticorps) induction may be a key component of long-lasting CNS plasticity.
Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes
findings suggest a novel function of HSF1 (Montrer HSF1 Anticorps) frequently overexpressed in cancer cells, to inhibit APC (Montrer APC Anticorps)/C activity by interacting with Cdc20, and to result in aneuploidy development and genomic instability
porcine FZR1 (Montrer FZR1 Anticorps) and CDC20 work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.
cell division cycle 20 homolog
, CDC20 cell division cycle 20 homolog
, cell division cycle protein 20 homolog
, cell cycle protein p55CDC