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The protein encoded by CDC27 shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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Dog (Canine) Monoclonal CDC27 Primary Antibody pour IF, IP - ABIN967980
Kramer, Scheuringer, Podtelejnikov, Mann, Peters: Mitotic regulation of the APC activator proteins CDC20 and CDH1. dans Molecular biology of the cell 2000
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Human Monoclonal CDC27 Primary Antibody pour IHC, ELISA - ABIN969035
Goto, Eddy: Speriolin is a novel spermatogenic cell-specific centrosomal protein associated with the seventh WD motif of Cdc20. dans The Journal of biological chemistry 2004
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Dog (Canine) Polyclonal CDC27 Primary Antibody pour EIA, WB - ABIN401299
Gabellini, Colaluca, Vodermaier, Biamonti, Giacca, Falaschi, Riva, Peverali: Early mitotic degradation of the homeoprotein HOXC10 is potentially linked to cell cycle progression. dans The EMBO journal 2003
Data indicate that UBE2S and APC3 co-regulate the expression level of P21 at G2/M check point via the ubiquitin-proteasome system.
Cdc27 is a novel binding partner of Elmo1 (Montrer ELMO1 Anticorps).Cdc27-Elmo1 (Montrer ELMO1 Anticorps) has a cellular role independent from the Elmo-Dock1 (Montrer DOCK1 Anticorps)-Rac (Montrer AKT1 Anticorps) signal module.
miR (Montrer MLXIP Anticorps)-27a could modulate proliferation and radiosensitivity of TNBC cells. CDC-27 is a direct target of miR (Montrer MLXIP Anticorps)-27a and its downregulation conferred increased radioresistance of the cells.
These findings suggested that polymorphisms in cdc27 may contribute to the susceptibility of BC though functional studies are needed to further elucidate the underling mechanisms of the associations
The structures show how one APC16 binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 recruits APC7 (Montrer ANAPC7 Anticorps) to APC3.
Low cdc27 and high securin (Montrer PTTG1 Anticorps) expression predict short survival for breast cancer patients.
Down-regulation of CDC27 protein is associated with radiation resistance.
Data indicate that additional density present in the anaphase-promoting complex (APC (Montrer APC Anticorps)/C) structure, proximal to Apc3/Cdc27 of the (tetratricopeptide repeat) lobe, is assigned to the TPR subunit Apc7 (Montrer ANAPC7 Anticorps), a subunit specific to vertebrate APC (Montrer APC Anticorps)/C.
the biochemical, structural, and cellular determinants of the novel interaction between MCPH1 (Montrer MCPH1 Anticorps) and Cdc27 and suggest that this interaction may occur within the larger context of MCPH1 (Montrer MCPH1 Anticorps)-APC (Montrer APC Anticorps)/C.
phosphorylation of Cdc27 by CKII (Montrer CSNK2A1 Anticorps) is involved in TGF-beta (Montrer TGFB1 Anticorps)-induced activation of APC (Montrer APC Anticorps).
Cdc27 directs cyclin D1 (Montrer CCND1 Anticorps) to alternative degradation by anaphase promoting complex/cyclosome.
The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eucaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and thus may be involved in controlling the timing of mitosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
cell division cycle 27 homolog (S. cerevisiae)
, cell division cycle 27 homolog
, cell division cycle protein 27 homolog
, CDC27 homolog
, anaphase promoting complex subunit 3
, anaphase-promoting complex subunit 3
, anaphase-promoting complex, protein 3
, nuc2 homolog