anti-Chromosome 12 Open Reading Frame 5 (C12orf5) Anticorps

C12orf5 is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. De plus, nous expédions Chromosome 12 Open Reading Frame 5 Protéines (3) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
C12orf5 57103 Q9NQ88
C12orf5 319801 Q8BZA9
C12orf5    
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Top anti-Chromosome 12 Open Reading Frame 5 Anticorps sur anticorps-enligne.fr

Showing 10 out of 32 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué WB Western Blot: TIGAR/C12orf5 Antibody  - Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE gel, diluted at 1:2000. 0.1 mL Connectez-vous pour afficher 8 to 11 Days
$447.56
Détails
Humain Lapin Inconjugué IHC (p), WB 50 μg Connectez-vous pour afficher 12 to 14 Days
$541.80
Détails
Humain Lapin Inconjugué IHC (p), WB 50 μg Connectez-vous pour afficher 12 to 14 Days
$541.80
Détails
Humain Souris Inconjugué WB Western Blot analysis of C12orf5 expression in transfected 293T cell line by C12orf5 MaxPab polyclonal antibody.<br><br>Lane 1: C12orf5 transfected lysate(29.7 KDa).<br>Lane 2: Non-transfected lysate.<br> 50 μL Connectez-vous pour afficher 11 to 12 Days
$430.00
Détails
Humain Lapin Inconjugué IHC (p), WB 50 μg Connectez-vous pour afficher 12 to 14 Days
$541.80
Détails
Humain Lapin Inconjugué IHC (p), WB 50 μg Connectez-vous pour afficher 12 to 14 Days
$541.80
Détails
Humain Souris Inconjugué IP, WB   0.05 mg Connectez-vous pour afficher 18 to 20 Days
$381.94
Détails
Humain Lapin Inconjugué ELISA, ICC, IF, IHC, IHC (p), WB   0.1 mg Connectez-vous pour afficher 8 to 11 Days
$447.56
Détails
Humain Lapin Inconjugué IHC (p), WB   0.025 mg Connectez-vous pour afficher 7 to 9 Days
$148.31
Détails
Humain Lapin Inconjugué IHC, IHC (p), WB   0.025 mL Connectez-vous pour afficher 7 to 9 Days
$148.31
Détails

C12orf5 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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Mouse (Murine) , ,


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Rat (Rattus) ,


Plus d’anticorps contre Chromosome 12 Open Reading Frame 5 partenaires d’interaction

Human Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. High TIGAR expression was an independent predictor of poor survival and high incidence of relapse in adult patients with CN-AML (Montrer RUNX1 Anticorps). TIGAR also showed high expression in multiple human leukemia cell lines and knockdown of TIGAR activated glycolysis through PFKFB3 (Montrer PFKFB3 Anticorps) upregulation in human leukemia cells.

  2. the upregulation of hsamiR101 in ccRCC was induced by hypoxia. Its expression deceased the protein expression of TIGAR and promoted glycolysis. This regulatory pathway may represent a novel mechanism of carcinogenesis and requires further investigation.

  3. TIGAR expression in breast carcinoma cells promotes metabolic compartmentalization and tumor growth with a mitochondrial metabolic phenotype with lactate and glutamine (Montrer GFPT1 Anticorps) catabolism.

  4. we investigate the crosstalk between PFKFB3 (Montrer PFKFB3 Anticorps) and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 (Montrer PFKFB3 Anticorps) knockdown

  5. The study showed that miR (Montrer MLXIP Anticorps)-101 inhibited viability, induced apoptosis, pushed glucose metabolism flux from the pentose phosphate pathway into glycolysis in prostate cancer PC3 (Montrer PCSK1 Anticorps) cell line by decreasing NADPH (Montrer NQO1 Anticorps) levels by throughly directly binding to 3'-UTR (Montrer UTS2R Anticorps) of TIGAR mRNA and repressing TIGAR expression.

  6. This study demonstrated that a high p53 (Montrer TP53 Anticorps) expression could be associated with the promotion of glycolysis in gastric cancer via the modulation of TIGAR expression.

  7. TIGAR expression may be used as a bio-marker for detection of colorectal cancer and can be used as a target for developing therapeutics for the treatment of colorectal cancer.

  8. TIGAR knockdown reduced tumor growth rate.

  9. Geranylgeranoic acid induced upregulation of the TIGAR gene, which might inhibit the glycolysis in HuH-7 cells with p53 (Montrer TP53 Anticorps) mutation.

  10. TIGAR over-expression could diminish the radiosensitivity of Hs 917.T cells, and the autophagy level induced by ionizing radiation (IR) was also decreased by TIGAR transfection.

Mouse (Murine) Chromosome 12 Open Reading Frame 5 (C12orf5) interaction partners

  1. Results suggest that TIGAR expression changes during development and its expression level may be correlated with the vulnerability of neurons to ischemic injury.

  2. Although mouse TIGAR expression is clearly induced in the intestines of mice following DNA-damaging stress of ionizing radiation, that was not dependent on p53 (Montrer TP53 Anticorps) or TAp73 (Montrer TP73 Anticorps).

  3. TIGAR protein expression in brain is increased following ischemia reperfusion injury.

  4. Therefore, we conclude that TIGAR knockdown-induced radiosensitization of glioma cells may be dependent on the inhibition of TRX1 (Montrer TXN Anticorps) nuclear translocation.

  5. TIGAR protects ischemic brain injury and preserves mitochodrial function.

  6. TIGAR has roles in efficient intestinal regeneration and tumorigenesis

  7. p53 (Montrer TP53 Anticorps)/TIGAR-mediated inhibition of myocyte mitophagy is responsible for impairment of mitochondrial integrity and subsequent apoptosis.

  8. p53 (Montrer TP53 Anticorps) and TIGAR inhibit glycolysis in hypoxic myocytes and that inhibition of glycolysis is closely involved in apoptosis, suggesting that p53 (Montrer TP53 Anticorps) and TIGAR are significant mediators of cellular energy homeostasis and cell death under ischemic stress.

Chromosome 12 Open Reading Frame 5 (C12orf5) profil antigène

Profil protéine

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

Gene names and symbols associated with C12orf5

  • TP53 induced glycolysis regulatory phosphatase (TIGAR) anticorps
  • TP53 induced glycolysis regulatory phosphatase (tigar) anticorps
  • TP53 induced glycolysis regulatory phosphatase S homeolog (tigar.S) anticorps
  • Trp53 induced glycolysis repulatory phosphatase (Tigar) anticorps
  • AA793651 anticorps
  • AI595337 anticorps
  • C12orf5 anticorps
  • C79710 anticorps
  • C85509 anticorps
  • FR2BP anticorps
  • Tigar anticorps

Protein level used designations for C12orf5

TP53-induced glycolysis and apoptosis regulator , fructose-2,6-bisphosphatase TIGAR , probable fructose-2,6-bisphosphatase TIGAR , chromosome 12 open reading frame 5 , fructose-2,6-bisphosphate 2-phosphatase , transactivated by NS3TP2 protein

GENE ID SPECIES
419040 Gallus gallus
100145723 Xenopus (Silurana) tropicalis
100226990 Taeniopygia guttata
57103 Homo sapiens
734566 Xenopus laevis
615392 Bos taurus
319801 Mus musculus
Fournisseurs de qualité sélectionnés pour anti-Chromosome 12 Open Reading Frame 5 (C12orf5) Anticorps
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