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CGNL1 encodes a member of the cingulin family. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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MgcRacGAP (Montrer RACGAP1 Anticorps) colocalizes with CGN (Montrer CGN Anticorps) and CGNL1 at TJs and forms a complex and interacts directly in vitro with CGN (Montrer CGN Anticorps) and CGNL1.
Results indentify plausible candidates include non-recurrent deletions at the glutamate transporter (Montrer SLC1A1 Anticorps) gene SLC1A1 (Montrer SLC1A1 Anticorps), a CNV locus recently suggested to be involved in schizophrenia through linkage analysis, and duplications at 1p36.33 and CGNL1.
ZO-1 (Montrer TJP1 Anticorps) and PLEKHA7 (Montrer PLEKHA7 Anticorps) are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively
Paracingulin regulates the activity of Rac1 and RhoA (Montrer RHOA Anticorps) GTPases by recruiting Tiam1 (Montrer TIAM1 Anticorps) and GEF-H1 (Montrer ARHGEF2 Anticorps) to epithelial junctions
This paper studied the mouse JACOP protein and found that the JACOP protein has structural and functional similarities to cingulin.
JACOP is involved in anchoring the apical junctional complex, especially TJs, to actin-based cytoskeletons.
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene.
cingulin-like protein 1
, cingulin-like 1
, junction-associated coiled-coil protein