Cyclophilin D (CYPD) Kits ELISA

The protein encoded by CYPD is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family.

list all ELISA KIts Gène GeneID UniProt
Anti-Rat CYPD CYPD 361967 Q6DGG0
Anti-Humain CYPD CYPD 5481 Q08752
Anti-Souris CYPD CYPD 105675 Q99KR7
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Plus Kits ELISA pour Cyclophilin D partenaires d'interaction

Human Cyclophilin D (CYPD) interaction partners

  1. This review discusses previous studies to provide comprehensive information on the physiological role of cyclophilin D as well as PTP opening in the cell that can be taken into consideration for the development of new PTP inhibitors. [review]

  2. The influx of unfolded p53 (Montrer TP53 Kits ELISA) into the mitochondrial matrix in response to oxidative stress indirectly activates the normally inhibited CypD by displacing it from Trap1 (Montrer TRAP1 Kits ELISA) complexes. This activates CypD's isomerase activity. Liberated CypD then isomerizes multiple proteins including p53 (Montrer TP53 Kits ELISA) (causing p53 (Montrer TP53 Kits ELISA) aggregation) and the structural components of the mPTP (Montrer PTPN2 Kits ELISA) pore, inducing pore opening.

  3. The present study is to investigate the role of CypD in regulating the mitochondrial dynamics relevant to oxidative stress induced (Montrer SQSTM1 Kits ELISA) neuron dysfunctions.

  4. CyPD regulates mitochondrial metabolism, and likely cell survival, by promoting more efficient electrons flow through the respiratory chain via increased supercomplex formation

  5. cyclophilin D (Montrer PPIF Kits ELISA) may modify mitochondrial features by inducing the translocation of molecules to the mitochondria through the mechanism associated with cellular energy metabolism

  6. The thermodynamics of binding of Cyp-40 (Montrer PPID Kits ELISA) to Hsp90 (Montrer HSP90 Kits ELISA) shows remarkable temperature sensitivity in the physiological temperature range.

  7. cyclophilin-D (Montrer PPIF Kits ELISA) protein could increase oxidative stress and cause endothelial cell injury and apoptosis. cyclophilin-D (Montrer PPIF Kits ELISA) protein is the key factor in reactive oxygen species-induced mitochondrial damage, leading to apoptosis of endothelial cells.

  8. Results show that CypD interacts with SPG7 and VDAC to form the mitochondrial permeability transition pore complex (PTP)and its CsA-binding region is necessary for PTP formation.

  9. molecular determinants necessary for Cyclophilin D (Montrer PPIF Kits ELISA) activity regulation and binding to proposed pore constituents thereby regulating the mitochondrial permeability transition pore.

  10. Cyp-D (Montrer PPIF Kits ELISA) silencing down-regulated mitochondrial transcripts initiated from the heavy strand promoter 2 [i.e., NADH dehydrogenase 1 (ND1 (Montrer MT-ND1 Kits ELISA)) by 11-fold; cytochrome oxidase 1 (COX1 (Montrer COX1 Kits ELISA)) by 4-fold; and ATP synthase subunit 6 (ATP6 (Montrer MT-ATP6 Kits ELISA)) by 6.5-fold.

Cow (Bovine) Cyclophilin D (CYPD) interaction partners

  1. Mannheimia haemolytica leukotoxin binds cyclophilin D (Montrer PPIF Kits ELISA) on bovine neutrophil mitochondria.

Mouse (Murine) Cyclophilin D (CYPD) interaction partners

  1. these data demonstrate that mitochondria are impaired in aging bone and that CypD deletion protects against this impairment to prevent bone loss. This implicates CypD-regulated MPTP (Montrer PTPN2 Kits ELISA) and mitochondrial dysfunction in the impairment of bone cells and in aging-related bone loss.

  2. Ppif (Montrer PPID Kits ELISA)+/+ and Ppif (Montrer PPID Kits ELISA)-/- eosinophils exhibited no significant difference in apoptosis or secondary necrosis.

  3. Ischemic postconditioning might prevent lethal reperfusion injury through an increased SIRT3 (Montrer SIRT3 Kits ELISA) activity and subsequent attenuation of CyPD acetylation at reperfusion.

  4. These findings reveal the role of HAX-1 (Montrer HAX1 Kits ELISA) in regulating cyclophilin-D (Montrer PPIF Kits ELISA) levels via an Hsp90 (Montrer HSP90 Kits ELISA)-dependent mechanism, resulting in protection against activation of mPTP (Montrer PTPN2 Kits ELISA) and subsequent cell death responses

  5. study identifies a novel signaling pathway composed of E2F1 (Montrer E2F1 Kits ELISA), miR (Montrer MLXIP Kits ELISA)-30b and CypD that regulates myocardial necrosis.

  6. It is concluded that CypD sensitizes the brain mitochondria to PT, and its inhibition by CsA (Montrer HSPA9 Kits ELISA) or CypD absence improves the complex I-related mitochondrial function and increases mitochondria stability against Ca(2 (Montrer CA2 Kits ELISA)+) stress.

  7. Data indicate that Ppif (Montrer PPID Kits ELISA) protein cyclophilin D (CypD)-dependent protein kinase A (PKA)/cAMP regulatory-element-binding (CREB (Montrer CREB1 Kits ELISA)) signaling is responsible for amyloid beta (Abeta (Montrer APP Kits ELISA))-induced synaptic injury.

  8. Ablation of CypD leads to changes in the mitochondrial acetylome which may contribute to altered mitochondrial metabolism in CypD-deficient mice.

  9. These results suggest a physiologic function for CypD and the mitochondrial permeability transition in the regulation of starvation-induced autophagy.

  10. new insights into CypD-dependent mitochondrial mPTP (Montrer PTPN2 Kits ELISA) and signaling on mitochondrial trafficking in axons and synaptic degeneration in an environment enriched for Abeta (Montrer APP Kits ELISA)

Cyclophilin D (CYPD) profil antigène

Antigen Summary

The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A.

Gene names and symbols associated with Cyclophilin D (CYPD) Kits ELISA

  • cyclophilin D (cypD) anticorps
  • cyclophilin D (LOC100152612) anticorps
  • peptidylprolyl isomerase D (Ppid) anticorps
  • peptidylprolyl isomerase D (PPID) anticorps
  • peptidylprolyl isomerase F (PPIF) anticorps
  • peptidylprolyl isomerase F (cyclophilin F) (Ppif) anticorps
  • AW457192 anticorps
  • CYP-40 anticorps
  • CyP-D anticorps
  • CyP-F anticorps
  • CYPD anticorps
  • DDBDRAFT_0205184 anticorps
  • DDBDRAFT_0215377 anticorps
  • DDB_0205184 anticorps
  • DDB_0215377 anticorps
  • PPIase anticorps

Protein level used designations for Cyclophilin D (CYPD) Kits ELISA

40 kDa peptidyl-prolyl cis-trans isomerase , Cyclophilin D , PPIase D , cyclophilin-40 , peptidyl-prolyl cis-trans isomerase D , rotamase D , 40 kDa peptidyl-prolyl cis-trans isomerase D , cyclophilin 40 , cyclophilin D , cyclophilin-related protein , PPIase F , cyclophilin F , peptidyl-prolyl cis-trans isomerase F, mitochondrial , peptidyl-prolyl cis-trans isomerase, mitochondrial , peptidylprolyl isomerase F (cyclophilin F) , rotamase F , mitochondrial Cyclophilin D

GENE ID SPECIES
8622540 Dictyostelium discoideum AX4
100152612 Sus scrofa
361967 Rattus norvegicus
5481 Homo sapiens
414346 Bos taurus
423723 Gallus gallus
105675 Mus musculus
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