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DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. De plus, nous expédions DNA Cross-Link Repair 1B, PSO2 Homolog (S. Cerevisiae) Protéines (4) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal DCLRE1B Primary Antibody pour IHC (p), WB - ABIN651618
Bae, Mukhopadhyay, Liu, Zhang, Tan, Akhter, Liu, Shen, Li, Legerski: Snm1B/Apollo mediates replication fork collapse and S Phase checkpoint activation in response to DNA interstrand cross-links. dans Oncogene 2008
Show all 4 Pubmed References
Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A (Montrer DCLRE1A Anticorps) and SNM1B.
The SNM1B/APOLLO DNA nuclease (Montrer DCLRE1C Anticorps) functions in resolution of replication stress and maintenance of common fragile site stability.
the N-terminal region of Snm1B forms a complex containing PSF2 (Montrer TAP2 Anticorps) and Mus81 (Montrer MUS81 Anticorps), while the C-terminal region is important for PSF2 (Montrer TAP2 Anticorps)-mediated chromatin association.
The nuclease (Montrer DCLRE1C Anticorps) hSNM1B/Apollo is linked to the Fanconi anemia (Montrer PALB2 Anticorps) pathway via its interaction with FANCP/SLX4 (Montrer BTBD12 Anticorps).
differences in the substrate selectivities of SNM1A (Montrer DCLRE1A Anticorps) and SNM1B are likely to be relevant to their in vivo roles
SNM1B functions epistatically to the central Fanconi anemia (Montrer PALB2 Anticorps) factor, FANCD2 (Montrer FANCD2 Anticorps), in cellular survival after interstrand crosslinks damage and homology-directed repair of DNA double-strand breaks
TRF2 (Montrer TERF2 Anticorps), which binds preferentially to positively supercoiled DNA substrates, together with Apollo, negatively regulates the amount of TOP1 (Montrer TOP1 Anticorps), TOP2alpha, and TOP2beta (Montrer TOP2B Anticorps) at telomeres.
siRNA knockdown of hSNM1B rendered cells sensitive to ionizing radiation, suggesting the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as intermediates of ICL repair
the C terminus of Snm1B was shown to interact with the TRF (Montrer IL5 Anticorps) homology domain of TRF2 (Montrer TERF2 Anticorps) indicating that Snm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2 (Montrer TERF2 Anticorps)
SNM1B (Apollo) protein exhibits a 5'-to-3' DNA exonuclease (Montrer EXO1 Anticorps) activity and functions together with TRF2 (Montrer TERF2 Anticorps) to protect telomeres from damage and fusion.
Study documents the combinatorial action of Apollo, POT1b, CST (Montrer CORT Anticorps), and the 5' exonuclease (Montrer EXO1 Anticorps) Exo1 (Montrer EXO1 Anticorps) in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
The telomeric protein (Montrer SYCE1 Anticorps) SNM1B/Apollo is required for normal cell proliferation and embryonic development
TRF2 (Montrer TERF2 Anticorps)-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM (Montrer ATM Anticorps) signaling, and protecting leading-end telomeres from fusion.
Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000
5' exonuclease Apollo
, DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)
, PSO2 homolog
, SNM1 homolog B
, DNA cross-link repair 1B protein