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DCX encodes a member of the doublecortin family. De plus, nous expédions Doublecortin Kits (33) et Doublecortin Protéines (11) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 157 products:
Human Monoclonal Doublecortin Primary Antibody pour WB - ABIN393267
Dijkmans, van Hooijdonk, Fitzsimons, Vreugdenhil: The doublecortin gene family and disorders of neuronal structure. dans Central nervous system agents in medicinal chemistry 2010
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Mouse (Murine) Monoclonal Doublecortin Primary Antibody pour IF, WB - ABIN968637
des Portes, Pinard, Billuart, Vinet, Koulakoff, Carrié, Gelot, Dupuis, Motte, Berwald-Netter, Catala, Kahn, Beldjord, Chelly: A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome. dans Cell 1998
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Human Polyclonal Doublecortin Primary Antibody pour ELISA, WB - ABIN1533167
Gleeson, Allen, Fox, Lamperti, Berkovic, Scheffer, Cooper, Dobyns, Minnerath, Ross, Walsh: Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein. dans Cell 1998
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Human Polyclonal Doublecortin Primary Antibody pour WB - ABIN871730
Pilz, Matsumoto, Minnerath, Mills, Gleeson, Allen, Walsh, Barkovich, Dobyns, Ledbetter, Ross: LIS1 and XLIS (DCX) mutations cause most classical lissencephaly, but different patterns of malformation. dans Human molecular genetics 1999
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Chicken Polyclonal Doublecortin Primary Antibody pour IHC, WB - ABIN2776750
Zhang, Ryan, Di Cesare, Liu, Walsh, You: Doublecortin is expressed in articular chondrocytes. dans Biochemical and biophysical research communications 2007
Human Monoclonal Doublecortin Primary Antibody pour ICC, FACS - ABIN969513
Evangelisti, Florian, Massimi, Dominici, Giannini, Galardi, Buè, Massalini, McDowell, Messi, Gulino, Farace, Ciafrè: MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness. dans FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009
From this family, we conclude that a DCX mutation causes a pleiotropic phenotype in the female even if X chromosome inactivation pattern is not skewed, and the novel missense mutation in DCX produced relatively mild dysfunction of the doublecortin protein.
We identified a novel DCX mutation c.785A > G, p.Asp262Gly in a family with X-linked lissencephaly and subcortical band heterotopia
In high-risk metastatic Neuroblastoma (Montrer ARHGEF16 Anticorps), TH and DCX mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.
Results point to a critical role of doublecortin in the formation of the neuromuscular junctions.
DCX-positive cells occur in a wide range of hypothalamic nuclei in humans, mice and sheep.
human DCX protein was expressed in human adipose stem cells, collagen II was decreased while aggrecan (Montrer ACAN Anticorps), matrilin 2 (Montrer MATN2 Anticorps), and GDF5 (Montrer GDF5 Anticorps) were increased during the 14-day pellet culture.
We propose that DCDC2 (Montrer DCDC2 Anticorps) is a tumor suppressor gene of HCC (Montrer FAM126A Anticorps).
in utero doublecortin knockdown, but not knockout, shows a neocortical neuronal migration phenotype.
Immunoblots revealed that depressed subjects displayed increased expression of doublecortin.
coexpression of DCX and SPARC (Montrer SPARC Anticorps) collaboratively diminished radioresistance of glioma cells.
Dcx is a new marker for the Pax7 (Montrer PAX7 Anticorps)(+)MyoD (Montrer MYOD1 Anticorps)(-) subpopulation, which contributes to myofiber maturation during muscle regeneration.
DCX-positive cells resembling immature and developing neurons were found in mice and sheep and human hypothalamus.
we showed that miR (Montrer MLXIP Anticorps)-29a directly regulated its target protein Doublecortin (DCX) expression, which further modulated axon branching in primary culture.
Cdk5 (Montrer CDK5 Anticorps) and its substrates, Dcx and p27kip1 (Montrer CDKN1B Anticorps), regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
Doublecortin knockout mice show lamination defects of the hippocampal pyramidal cell layer largely restricted to the CA3 (Montrer CA3 Anticorps) region.
Dcx protein- and mRNA-levels reflected changes in neurogenesis
DCX is dispensable for the development of new neurons in adult mice
results indicate that immature DCX-expressing neurons are required for successful acquisition of spatial learning, as well as reversal learning, but are not necessary for the retrieval of stored long-term memories.
In axons from mice mutant for Dcx, widespread differences are found in actin-associated proteins as compared with wild-type axons
analysis of doublecortin expressing neurons in the adult mouse dentate gyrus
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
doublecortex; lissencephaly, X-linked (doublecortin)
, neuronal migration protein doublecortin
, lissencephaly, X-linked (doublecortin)