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ELOVL5 plays a role in elongation of long-chain polyunsaturated fatty acids (Leonard et al., 2000. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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This study investigated the expression of genes encoding enzymes involved in long-chain polyunsaturated fatty acids biosynthesis, namely fatty acyl desaturase (Fad (Montrer PSEN1 Anticorps)) and Elovl5- and Elovl2 (Montrer ELOVL2 Anticorps)-like elongases, during early embryonic development of zebrafish.
These studies establish that Elovl5 activity regulates hepatic levels of FAs (Montrer FAS Anticorps) controlling PPARbeta (Montrer PPARD Anticorps) activity, ATGL (Montrer PNPLA2 Anticorps) expression, and TG catabolism, but not FA oxidation.
knockdown of Elovl5, Fads1 (Montrer FADS1 Anticorps), or Fads2 (Montrer FADS2 Anticorps) decreased the level of Mead acid.
a novel link between Elovl5-mediated synthesis of 18:1,n-7 and GNG through the control of the mTORC2 (Montrer CRTC2 Anticorps)-Akt (Montrer AKT1 Anticorps)-FoxO1 (Montrer FOXO1 Anticorps) pathway
Results establish a link between fatty acid elongation and hepatic glucose metabolism and suggest a role for regulators of Elovl5 activity in the treatment of diet-induced hyperglycemia.
Elovl5-induced changes in hepatic fatty acid content affect multiple pathways regulating hepatic lipid and carbohydrate composition
reduced ELOVL5 activity leads to hepatic steatosis, and endogenously synthesized PUFAs are key regulators of SREBP-1c (Montrer SREBF1 Anticorps) activation and fatty acid synthesis in liver
Low ELOVL5 expression is associated with colorectal cancer.
SCA38 subtype is very rare in Mainland China; no disease-related gene mutations in ELOVL5.
performed a detailed promoter/enhancer analysis of ELOVL5 gene, and identified two new SREBP binding sites, one in the 10 kb upstream region and one in the exon 1
In transfection experiments, subcellular localization of altered ELOVL5 showed a perinuclear distribution with a signal increase in the Golgi compartment, whereas the wild-type showed a widespread signal in the endoplasmic reticulum.
Changes in the mRNA-expression levels of FADS1 (Montrer FADS1 Anticorps) and 2 directly affect blood DGLA levels and D6D (Montrer FADS2 Anticorps) activity. This study suggests that lower mRNA-expressions of FADS2 (Montrer FADS2 Anticorps) and ELOVL5 are associated with higher risk of atopic eczema in young children.
Typical POAG associated with ELOVL5 gene polymorphism may have a late rather than an early onset.
Not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele.
Our genome-wide association study identified SRBD1 and ELOVL5 as new susceptibility genes for (normal tension glaucoma) NTG (Montrer OPA1 Anticorps).
we performed association analysis between the genotypes and traits and our result revealed that T allele of g.-110T>C in ELOVL5 gene promoter indicated significantly thinner subcutaneous fat thickness than that of C allele
ELOVL5 plays a role in elongation of long-chain polyunsaturated fatty acids (Leonard et al., 2000
elongation of very long chain fatty acids protein 5
, ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like, yeast)
, elongation of long chain fatty acids family member 5
, elongation of very long chain fatty acids protein
, homolog of yeast long chain polyunsaturated fatty acid elongatio
, 3-keto acyl-CoA synthase Elovl5
, ELOVL FA elongase 5
, ELOVL family member 5, elongation of long chain fatty acids (FEN1/Elo2, SUR4/Elo3-like)
, elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
, elongation of very long chain fatty acids-like 2
, very-long-chain 3-oxoacyl-CoA synthase 5
, 3-keto acyl-CoA synthase ELOVL5
, ELOVL fatty acid elongase 5
, fatty acid elongase 1
, homolog of yeast long chain polyunsaturated fatty acid elongation enzyme
, homolog of yeast long chain polyunsaturated fatty acid elongation enzyme 2
, ELOVL family member 5, elongation of long chain fatty acids
, elongation of very long chain fatty acids-like 5
, 3-keto acyl-CoA synthase elovl5