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Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. De plus, nous expédions Elastase, Neutrophil Expressed Kits (103) et Elastase, Neutrophil Expressed Protéines (16) et beaucoup plus de produits pour cette protéine.
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Dog (Canine) Polyclonal ELANE Primary Antibody pour FACS, IF (p) - ABIN1386058
Jeffery, Kimura, Gray, Lueth, Bellaire, LeVine: Dogs cast NETs too: Canine neutrophil extracellular traps in health and immune-mediated hemolytic anemia. dans Veterinary immunology and immunopathology 2015
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Human Polyclonal ELANE Primary Antibody pour IA - ABIN2192191
Dentener, Francot, Hiemstra, Tool, Verhoeven, Vandenabeele, Buurman: Bactericidal/permeability-increasing protein release in whole blood ex vivo: strong induction by lipopolysaccharide and tumor necrosis factor-alpha. dans The Journal of infectious diseases 1997
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The role of neutrophil elastase in the activation of unfolded protein response effector molecules via PERK (Montrer EIF2AK3 Anticorps) and CHOP (Montrer DDIT3 Anticorps) is reported.
results suggest activation of elastase in tendinopathy of the long head of the biceps increases the degradation of elastin (Montrer ELN Anticorps) to increase the levels of elastase, becoming a vicious cycle to the progressive severity of tendinopathy
Coincubation with the inhibitors, particularly MK0339, promoted cell survival and increased formation of mature neutrophils. These studies suggest that cell-permeable inhibitors of neutrophil elastase show promise as novel therapies for ELANE-associated neutropenia.
Data suggest that neuropilin-1 (NRP1 (Montrer NRP1 Anticorps)) functions as a receptor for neutrophil elastase (NE), mediates uptake/absorption of NE, and facilitates cross-presentation of PR1 (Montrer TMEM37 Anticorps) (a peptide fragment of NE) in breast cancer cells.
This study proposes that acquisition of CSF3R (Montrer CSF3R Anticorps) mutations may represent a mechanism by which myeloid precursor cells carrying the ELANE mutations evade the proapoptotic activity of the Neutrophil Elastase mutants in SCN (Montrer SRI Anticorps) patients.
Faecal biomarkers lactoferrin (Montrer LTF Anticorps), calprotectin (Montrer S100A8 Anticorps), and PMN-elastase were able to distinguish between ulcerative colitis patients with mucosal healing from clinical remission and mild disease, showed significant correlations with endoscopy, and were predictive of a flare.
In conclusion, site-specific CBG (Montrer SERPINA6 Anticorps) N-glycosylation regulates the bioavailability of cortisol in inflamed environments by fine-tuning the RCL (Montrer C6orf108 Anticorps) proteolysis by endogenous and exogenous elastases.
Although circulating nucleosomes and elastase - alpha 1-antitrypsin (Montrer SERPINA1 Anticorps) complexes are at present the best characterized biomarkers for neutrophil extracellular traps formation and neutrophil activation, their lack of association with rs2288904 genotype does not exclude a role for SLC44A2 (Montrer SLC44A2 Anticorps) in neutrophil activation (and possibly NET formation) in Venous Thromboembolism.
The levels of both NE and PR3 correlated with absolute neutrophil counts and are reduced in type 1 diabetes mellitus patients.
The results of the present study may indicate that NE activates the phosphoinositide-3 kinase/Akt (Montrer AKT1 Anticorps) signaling pathway in leukemia cells to inhibit apoptosis and enhance cell proliferation
Levels of neutrophil elastase (NE) and the nuclear factors CCAAT/enhancer-binding protein alpha (C/EBPalpha (Montrer CEBPA Anticorps)) and growth factor-independent 1 (GFI-1) are elevated in hematopoietic stem and progenitor cells from high-fat diet (HFD)-fed mice, but mice lacking either NE or C/EBPalpha (Montrer CEBPA Anticorps) are resistant to HFD-induced myelopoiesis.
Sivelestat treatment significantly reduced the protein level, neutrophil count, neutrophil elastase activity in bronchoalveolar lavage fluid (BALF).
Serine protease (Montrer F2 Anticorps) required for resistance to microbial infection; contributes to pathogenessis in endotoxic shock
Neutrophils from neutrophil elastase-deficient mice show no defect in transendothelial migration
results of ultrasound studies using the elastase and AngII apoE (Montrer APOE Anticorps) in 4 biomechanical parameters: aneurysm diameter, aneurysm volume, circumferential cyclic strain, and blood flow velocity
Sirtinol is a novel HNE inhibitor and may have the potential for clinical application in the treatment of inflammatory lung diseases.
SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase
Increased ELANE activity was associated with development of autoimmune diabetes mellitus in NOD mice.
Neutrophil elastase is involved in the induction of microbicidal activities of neutrophils against Trypanosoma cruzi-infected macrophages.
In conclusion, sivelestat reduced radiationinduced lung injury in the mice by suppressing neutrophil elastase activity and excessive inflammatory reactions
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation.
elastase 2, neutrophil
, neutrophil elastase
, elastase, neutrophil expressed
, chymotrypsin-like elastase family member 2A
, pancreatic elastase II
, PMN elastase
, bone marrow serine protease
, granulocyte-derived elastase
, human leukocyte elastase
, leukocyte elastase
, polymorphonuclear elastase
, serine protease