Endogenous Retrovirus Group W, Member 1 Protéines (ERVW-1)

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. De plus, nous expédions ERVW-1 Anticorps (46) et beaucoup plus de produits pour cette protéine.

afficher tous les protéines Gène GeneID UniProt
ERVW-1 30816 Q9UQF0
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Catalogue No. Origin Source Conjugué Images Quantité Fournisseur Livraison Prix Détails
Cellules d'insectes Humain His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Connectez-vous pour afficher 50 Days
Wheat germ Humain GST tag 10 μg Connectez-vous pour afficher 11 to 12 Days

ERVW-1 Protéines protéines par origine et source

Origin Exprimée danse Conjugué
Human ,
, ,

ERVW-1 Protéines mieux référencés

  1. Human ERVW-1 Protein expressed in Wheat germ - ABIN1353105 : Holder, Tower, Forbes, Mulla, Aplin, Abrahams: Immune cell activation by trophoblast-derived microvesicles is mediated by syncytin 1. dans Immunology 2012 (PubMed)

Plus protéines pour Endogenous Retrovirus Group W, Member 1 (ERVW-1) partenaires d'interaction

Human Endogenous Retrovirus Group W, Member 1 (ERVW-1) interaction partners

  1. CD47 (Montrer CD47 Protéines) seems to mediate fusion mostly through broad contact surfaces between the partners' cell membrane while syncytin-1 mediate fusion through phagocytic-cup like structure.

  2. ERVWE1, ERVFRDE1 and ERV3 (Montrer ERV3-1 Protéines) transcription was down-regulated in hydatidiform moles and gestational trophoblastic neoplasia.

  3. Study found no associations between embroynal ERVW-1 polymorphisms and preeclampsia.

  4. Identification of the two CpG dinucleotides around transcription start site as key epigenetic elements has provided valuable information for further studies on the epigenetic regulation of syncytin-1 in pancreatic cancer cells

  5. Syncytin-1 and ASCT-2 (Montrer SLC1A5 Protéines) is localized at the acrosomal region and equatorial segment of the spermatozoa.

  6. The effect of ETS1 (Montrer ETS1 Protéines) on syncytialization of trophoblasts likely results, at least in part, from inhibition of syncytin expression.

  7. These results indicated that aberrant hypermethylation is involved in downregulation of syncytin-1, and epigenetic alterations may play a significant role in the development of preeclampsia

  8. Exosomes from cultured primary villous cytotrophoblasts and sera of pregnant women have syncytin-1 on their surfaces. It acts on cellular binding and uptake of exosomes.

  9. Increased trophoblast apoptosis and altered expression levels of syncytin-1, calpain 1 (Montrer CAPN1 Protéines), and AIF (Montrer AIFM1 Protéines) is observed in preeclamptic placentas.

  10. Syncytin-1 overexpression may be an indicator of urothelial cell carcinoma risk.

Profil protéine ERVW-1

Profil protéine

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with ERVW-1

  • endogenous retrovirus group W member 1, envelope (ERVW-1)
  • ENV Protéine
  • ENVW Protéine
  • ERVWE1 Protéine
  • HERV-7q Protéine
  • HERV-W-ENV Protéine
  • HERV7Q Protéine
  • HERVW Protéine
  • HERVWENV Protéine

Protein level used designations for ERVW-1

HERV-7q envelope protein , HERV-W Env glycoprotein , HERV-W envelope protein , HERV-W_7q21.2 provirus ancestral Env polyprotein , HERV-W{7q21.1} provirus ancestral Env polyprotein , HERV-tryptophan envelope protein , endogenous retroviral family W, env(C7), member 1 , endogenous retrovirus group W member 1 , env-W , envelope glycoprotein , envelope polyprotein gPr73 , envelope protein , enverin , human endogenous retrovirus W envC7-1 envelope protein , syncytin A , syncytin-1

30816 Homo sapiens
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