anti-Ewing Sarcoma Breakpoint Region 1 (EWSR1) Anticorps

EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. De plus, nous expédions EWSR1 Protéines (4) et EWSR1 Kits (3) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
EWSR1 14030 Q61545
EWSR1 2130 Q01844
EWSR1 289752  
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Top anti-EWSR1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 153 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB <b>WB Suggested Anti-EWSR1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB <b>WB Suggested Anti-EWSR1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Boeuf (Vache) Lapin Inconjugué IHC, WB <b>WB Suggested Anti-EWSR1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Jurkat cell lysate WB Suggested Anti-EWSR1 <br /> Antibody Titration: 0.2-1 µg/mL <br /> Positive Control: Jurkat cell lysate <br /> EWSR1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Connectez-vous pour afficher 2 to 3 Days
$289.00
Détails
Humain Lapin Inconjugué IHC (p), WB Anti- EWSR1 Picoband antibody, IHC(P) IHC(P): Human Mammary Cancer Tissue 100 μg Connectez-vous pour afficher 4 to 6 Days
$240.00
Détails
Humain Lapin Inconjugué IF, WB Western blot analysis of EWSR1 (arrow) using rabbit polyclonal EWSR1 Antibody (C-term) (ABIN658497). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the EWSR1 gene. 400 μL Connectez-vous pour afficher 10 to 11 Days
$324.50
Détails
Boeuf (Vache) Lapin Inconjugué WB Western blot analysis of EWS expression in HepG2 (A), Jurkat (B), HeLa (C) whole cell lysates. 200 μL Connectez-vous pour afficher 13 to 14 Days
$487.50
Détails
Humain Lapin Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 2 to 3 Days
$302.50
Détails
Boeuf (Vache) Chèvre Inconjugué EIA, IHC (p), WB   0.1 mg Connectez-vous pour afficher 12 to 15 Days
$375.38
Détails
Humain Chèvre Inconjugué IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: EWSR1 Antibody [NBP1-28798] - (3.8ug/ml) staining of Human Small Intestine. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. 0.1 mg Connectez-vous pour afficher 7 to 9 Days
$408.19
Détails
Humain Lapin Inconjugué IP, WB Western Blot: EWSR1 Antibody  - Detection of Human and Mouse EWS by Western Blot. Samples: Whole cell lysate (15 and 50 ug) from HeLa and mouse NIH3T3 cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-EWS antibody  used for WB at 0.04 ug/ml. Detection: Chemiluminescence with an exposure time of 3 seconds. 100 μL Connectez-vous pour afficher 7 to 9 Days
$486.94
Détails

EWSR1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
Mouse (Murine)
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Rat (Rattus)
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anti-EWSR1 Anticorps mieux référencés

  1. Human Polyclonal EWSR1 Primary Antibody pour ICC, IF - ABIN152318 : Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. dans Cancer cell 2006 (PubMed)

  2. Human Polyclonal EWSR1 Primary Antibody pour IP, WB - ABIN152319 : Sohn, Park, Kang, Wu: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. dans Biochemical and biophysical research communications 2012 (PubMed)

  3. Human Polyclonal EWSR1 Primary Antibody pour IHC (p), IHC - ABIN449908 : Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. dans Cancer research 2006 (PubMed)

Plus d’anticorps contre EWSR1 partenaires d’interaction

Mouse (Murine) Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Gnai1 (Montrer GNAI1 Anticorps) function is impaired in the spinal cord of Ews/Ewsr1 KO mice

  2. EWS is normally O-GlcNAc glycosylated in the brain.

  3. glycosylation of EWS protein

  4. EWSR1 is involved in the post-transcriptional regulation of Uvrag (Montrer UVRAG Anticorps) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.

  5. EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (Montrer BMP2 Anticorps) and BMP4 (Montrer BMP4 Anticorps) expression.

  6. EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (Montrer PPARGC1A Anticorps) protein stability

  7. both Etv1 (Montrer ETV1 Anticorps) and Ewsr1 were necessary for Fgf10 (Montrer FGF10 Anticorps) expression and elongation of the limb bud.

  8. EWS is involved in post-transcriptional regulation of Col4a1 (Montrer COL4A1 Anticorps) and CTGF (Montrer CTGF Anticorps) via a Drosha (Montrer DROSHA Anticorps)-miRNA-dependent pathway.

  9. These results demonstrate that EWS is essential for early brown fat lineage determination.

  10. Forced expression of EWS/ATF1 (Montrer AFT1 Anticorps) resulted in the development of EWS/ATF1 (Montrer AFT1 Anticorps)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (Montrer AFT1 Anticorps)-driven transformation.

Zebrafish Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Mutation of the EWS gene modulates Sox9 (Montrer SOX9 Anticorps) gene expression essential for chondrocyte differentiation.

  2. Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development

  3. Interaction between EWSR1/FLI1 (Montrer FLI1 Anticorps) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.

Human Ewing Sarcoma Breakpoint Region 1 (EWSR1) interaction partners

  1. Recent advances in biologic and genomic understanding of these two cancers has expanded the potential for therapeutic advancement and prevention. In Ewing sarcoma, directed focus on inhibition of EWSR1-FLI1 (Montrer FLI1 Anticorps) and its effectors has produced promising results.

  2. data suggest EWS/FLI (Montrer FLII Anticorps) binds to "promoter-like" and "enhancer-like" microsatellites to mediate activation and repression of target genes through different regulatory mechanisms

  3. four oncogenic ETS (Montrer ETS1 Anticorps) (ERG (Montrer ERG Anticorps), ETV1 (Montrer ETV1 Anticorps), ETV4 (Montrer ETV4 Anticorps), and ETV5 (Montrer ETV5 Anticorps)), and no other ETS (Montrer ETS1 Anticorps), interact with the Ewing's sarcoma breakpoint protein, EWS.

  4. As spontaneous fluctuations in EWS-FLI1 (Montrer FLI1 Anticorps) levels of Ewing sarcoma cells in vitro and in vivo, associated with a switch between a proliferative, non-migratory EWS-FLI1 (Montrer FLI1 Anticorps)-high and a non-proliferative highly migratory EWS-FLI1 (Montrer FLI1 Anticorps)-low state, were recently described, our data provide a mechanistic basis for the underlying EWS-FLI1 (Montrer FLI1 Anticorps)-dependent reversible cytoskeletal reprogramming of Ewing sarcoma cells.

  5. Fusion of short fragments of EWSR1 to FLI1 (Montrer FLI1 Anticorps) is sufficient to recapitulate BAF (Montrer BANF1 Anticorps) complex retargeting and EWS-FLI1 (Montrer FLI1 Anticorps) activities; studies thus demonstrate that the physical properties of prion (Montrer PRNP Anticorps)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.

  6. Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 (Montrer AFT1 Anticorps) gene fusion.

  7. Results expand the spectrum of tumor types harboring EWSR1/FUS (Montrer FUS Anticorps)-ATF1 (Montrer AFT1 Anticorps) gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.

  8. papillary thyroid carcinomas with EWSR1 rearrangement disclosed a lower percentage of nuclei with EWSR1 polysomy than those without EWSR1 rearrangement

  9. The net result of combined lurbinectedin and irinotecan treatment was a complete reversal of EWS-FLI1 (Montrer FLI1 Anticorps) activity and elimination of established tumors in 30% to 70% of mice after only 11 days of therapy. Our results illustrate the preclinical safety and efficacy of a disease-specific therapy targeting the central oncogenic driver in Ewing sarcoma.

  10. Aggregation of FET proteins FUS (Montrer FUS Anticorps), EWSR1, and TAF15 (Montrer TAF15 Anticorps) mediate a pathological change in amyotrophic lateral sclerosis. (Review)

EWSR1 profil antigène

Profil protéine

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.

Gene names and symbols associated with EWSR1

  • EWS RNA binding protein 1 (EWSR1) anticorps
  • EWS RNA binding protein 1 (ewsr1) anticorps
  • Ewing sarcoma breakpoint region 1 (Ewsr1) anticorps
  • EWS RNA-binding protein 1a (ewsr1a) anticorps
  • EWS RNA-binding protein 1 (Ewsr1) anticorps
  • AU018891 anticorps
  • bK984G1.4 anticorps
  • DKFZp459K1116 anticorps
  • Ews anticorps
  • Ewsh anticorps
  • EWSR1 anticorps
  • fc04c01 anticorps
  • wu:fc04c01 anticorps

Protein level used designations for EWSR1

RNA-binding protein EWS , Ewing sarcoma RNA-binding protein , Ewing sarcoma breakpoint region 1 , Ewing sarcoma homolog , Ewings sarcoma EWS-Fli1 (type 1) oncogene

GENE ID SPECIES
748264 Pan troglodytes
100034010 Equus caballus
100018014 Monodelphis domestica
100173925 Pongo abelii
100550662 Meleagris gallopavo
100557388 Anolis carolinensis
100595788 Nomascus leucogenys
417022 Gallus gallus
609786 Canis lupus familiaris
534073 Bos taurus
14030 Mus musculus
100156911 Sus scrofa
323597 Danio rerio
2130 Homo sapiens
289752 Rattus norvegicus
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