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EWSR1 encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. De plus, nous expédions EWSR1 Protéines (4) et EWSR1 Kits (3) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 152 products:
Human Polyclonal EWSR1 Primary Antibody pour IF, WB - ABIN658497
Lagirand-Cantaloube, Laud, Lilienbaum, Tirode, Delattre, Auclair, Kryszke: EWS-FLI1 inhibits TNFalpha-induced NFkappaB-dependent transcription in Ewing sarcoma cells. dans Biochemical and biophysical research communications 2010
Show all 5 references for 658497
Human Polyclonal EWSR1 Primary Antibody pour ELISA, WB - ABIN1451580
Delattre, Zucman, Plougastel, Desmaze, Melot, Peter, Kovar, Joubert, de Jong, Rouleau: Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. dans Nature 1992
Show all 2 references for 1451580
Human Polyclonal EWSR1 Primary Antibody pour IP, WB - ABIN152319
Sohn, Park, Kang, Wu: Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS. dans Biochemical and biophysical research communications 2012
Human Polyclonal EWSR1 Primary Antibody pour ICC, IF - ABIN152318
Davis, Kim, Ozsolak, Widlund, Rozenblatt-Rosen, Granter, Du, Fletcher, Denny, Lessnick, Linehan, Kung, Fisher: Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers. dans Cancer cell 2006
Human Polyclonal EWSR1 Primary Antibody pour IHC (p), IHC - ABIN449908
Toretsky, Erkizan, Levenson, Abaan, Parvin, Cripe, Rice, Lee, Uren: Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A. dans Cancer research 2006
Cow (Bovine) Polyclonal EWSR1 Primary Antibody pour IHC, WB - ABIN2779045
Brandal, Panagopoulos, Bjerkehagen, Gorunova, Skjeldal, Micci, Heim: Detection of a t(1;22)(q23;q12) translocation leading to an EWSR1-PBX1 fusion gene in a myoepithelioma. dans Genes, chromosomes & cancer 2008
EWS is normally O-GlcNAc glycosylated in the brain.
glycosylation of EWS protein
EWSR1 is involved in the post-transcriptional regulation of Uvrag (Montrer UVRAG Anticorps) via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
EWS is essential during the early steps of white adipocyte differentiation, at least in part through its regulation of BMP2 (Montrer BMP2 Anticorps) and BMP4 (Montrer BMP4 Anticorps) expression.
EWS has a role in mitochondrial and cellular energy homeostasis that involves controlling PGC-1alpha (Montrer PPARGC1A Anticorps) protein stability
both Etv1 (Montrer ETV1 Anticorps) and Ewsr1 were necessary for Fgf10 (Montrer FGF10 Anticorps) expression and elongation of the limb bud.
EWS is involved in post-transcriptional regulation of Col4a1 (Montrer COL4A1 Anticorps) and CTGF (Montrer CTGF Anticorps) via a Drosha (Montrer DROSHA Anticorps)-miRNA-dependent pathway.
These results demonstrate that EWS is essential for early brown fat lineage determination.
Forced expression of EWS/ATF1 (Montrer AFT1 Anticorps) resulted in the development of EWS/ATF1 (Montrer AFT1 Anticorps)-dependent sarcomas. Lineage-tracing experiments indicated that neural crest-derived cells were subject to EWS/ATF1 (Montrer AFT1 Anticorps)-driven transformation.
these findings suggest that EWS mediates generation of mature let-7g from pre-let-7g.
Mutation of the EWS gene modulates Sox9 (Montrer SOX9 Anticorps) gene expression essential for chondrocyte differentiation.
Ewsr1 maintains mitotic integrity and proneural cell survival in early zebrafish development
Interaction between EWSR1/FLI1 (Montrer FLI1 Anticorps) and EWSR1 in Ewing sarcoma may induce mitotic defects leading to genomic instability and subsequent malignant transformation.
Fusion of short fragments of EWSR1 to FLI1 (Montrer FLI1 Anticorps) is sufficient to recapitulate BAF (Montrer BANF1 Anticorps) complex retargeting and EWS-FLI1 (Montrer FLI1 Anticorps) activities; studies thus demonstrate that the physical properties of prion (Montrer PRNP Anticorps)-like domains can retarget critical chromatin regulatory complexes to establish and maintain oncogenic gene expression programs.
Case Reports: maxillary sinus clear cell carcinomas with EWSR1-ATF1 (Montrer AFT1 Anticorps) gene fusion.
Results expand the spectrum of tumor types harboring EWSR1/FUS (Montrer FUS Anticorps)-ATF1 (Montrer AFT1 Anticorps) gene fusions to include a subgroup of conventional epithelioid malignant mesothelioma.
papillary thyroid carcinomas with EWSR1 rearrangement disclosed a lower percentage of nuclei with EWSR1 polysomy than those without EWSR1 rearrangement
The net result of combined lurbinectedin and irinotecan treatment was a complete reversal of EWS-FLI1 (Montrer FLI1 Anticorps) activity and elimination of established tumors in 30% to 70% of mice after only 11 days of therapy. Our results illustrate the preclinical safety and efficacy of a disease-specific therapy targeting the central oncogenic driver in Ewing sarcoma.
Aggregation of FET proteins FUS (Montrer FUS Anticorps), EWSR1, and TAF15 (Montrer TAF15 Anticorps) mediate a pathological change in amyotrophic lateral sclerosis. (Review)
A subgroup of MAML2 (Montrer MAML2 Anticorps) fusion-negative mucoepidermoid carcinomas are actually clear cell carcinoma of the salivary gland with EWSR1 translocation.
Study found consistent DNA hypomethylation at enhancers regulated by the disease-defining EWS-FLI1 (Montrer FLI1 Anticorps) fusion protein, thus establishing epigenomic enhancer reprogramming as a ubiquitous and characteristic feature of Ewing sarcoma.
Report a distinct group of myxoid mesenchymal neoplasms occurring in children or young adults with a predilection for intracranial locations with EWSR1-AFT1/CREB1 (Montrer CREB1 Anticorps)/CREM (Montrer CREM Anticorps) fusions.
We conclude that in the context of 22q11-12 regional alterations present in SMARCB1 (Montrer SMARCB1 Anticorps)-deleted tumors, simultaneous EWSR1 involvement may be misinterpreted as equivalent to EWSR1 rearrangement. A detailed clinicopathologic correlation and supplementing the EWSR1 FISH assay with complementary methodology is mandatory for correct diagnosis
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14.
RNA-binding protein EWS
, Ewing sarcoma RNA-binding protein
, Ewing sarcoma breakpoint region 1
, Ewing sarcoma homolog
, Ewings sarcoma EWS-Fli1 (type 1) oncogene