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FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. De plus, nous expédions F-Box Protein 4 Kits (12) et F-Box Protein 4 Protéines (5) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal FBXO4 Primary Antibody pour WB - ABIN233769
Pontano, Aggarwal, Barbash, Brown, Bassing, Diehl: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. dans Molecular and cellular biology 2008
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Cow (Bovine) Polyclonal FBXO4 Primary Antibody pour ELISA - ABIN4271628
Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. dans Cancer cell 2008
Cow (Bovine) Polyclonal FBXO4 Primary Antibody pour WB - ABIN2774698
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... dans Molecular systems biology 2007
Human Polyclonal FBXO4 Primary Antibody pour EIA, WB - ABIN952288
Zeng, Wang, Yang, Chen, Yang, Diehl, Liu, Lei: Structural basis of selective ubiquitination of TRF1 by SCFFbx4. dans Developmental cell 2010
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results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 (Montrer CCND1 Anticorps) degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 (Montrer CCND1 Anticorps) expression in human cancers.
The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.
14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.
Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.
results reveal an atypical small GTPase (Montrer RACGAP1 Anticorps) domain within Fbx4 as a substrate-binding motif for SCF (Montrer KITLG Anticorps)(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 (Montrer TERF1 Anticorps) in telomere homeostasis control
Fbx4 is a central regulator of Pin2/TRF1 (Montrer TERF1 Anticorps) protein abundance and alterations in the stability of Pin2/TRF1 (Montrer TERF1 Anticorps) can have a dramatic impact on telomere length
SCF (Montrer KITLG Anticorps)(FBX4-alphaB crystallin (Montrer CRYAB Anticorps)) is an E3 ubiquitin ligase (Montrer MUL1 Anticorps) that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1 (Montrer CCND1 Anticorps).
Mutations in Fbx4 inhibit dimerization of the SCF (Montrer KITLG Anticorps)(Fbx4) ligase and contribute to cyclin D1 (Montrer CCND1 Anticorps) overexpression in human cancer.
Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis
This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.
Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 (Montrer CCND1 Anticorps) deregulation and nuclear accumulation
Lysine 269 is essential for cyclin D1 (Montrer CCND1 Anticorps) ubiquitylation by the SCF (Montrer KITLG Anticorps)(Fbx4/alphaB-crystallin (Montrer CRYAB Anticorps)) ligase.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.
F-box only protein 4
, F-box protein Fbx4
, F-box protein 4
, F-box only protein 4-like