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FBXL19 encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. De plus, nous expédions FBXL19 Kits (12) et FBXL19 Protéines (3) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal FBXL19 Primary Antibody pour WB - ABIN1537454
Wei, Mialki, Dong, Khoo, Mallampalli, Zhao, Zhao: A new mechanism of RhoA ubiquitination and degradation: Roles of SCF(FBXL19) E3 ligase and Erk2. dans Biochimica et biophysica acta 2013
Show all 3 references for 1537454
Collectively these data unveil that FBXL19 functions as an antagonist of Rac3 (Montrer RAC3 Anticorps) by regulating its stability and regulates the TGFbeta1 (Montrer TGFB1 Anticorps)-induced E-cadherin (Montrer CDH1 Anticorps) down-regulation.
SCF (Montrer KITLG Anticorps)(FBXL19) targets RhoA (Montrer RHOA Anticorps) for its disposal, a process regulated by Erk2 (Montrer MAPK1 Anticorps).
Data indicate that overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration.
The fundamental observation was that FBXL19 attenuated IL-33 (Montrer IL33 Anticorps)-mediated activity by removing ST2L (Montrer TMED1 Anticorps), but not sST2 (Montrer SSTR2 Anticorps) or IL-1R1, on the cell surface.
This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein binds to the transmembrane receptor ST2L and regulates its ubiquination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants.
F-box/LRR-repeat protein 19
, F-box and leucine-rich repeat protein 19
, f-box/LRR-repeat protein 19-like
, jumonji C domain-containing histone demethylase 1C