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FAM3C is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. De plus, nous expédions FAM3C Protéines (17) et FAM3C Kits (2) et beaucoup plus de produits pour cette protéine.
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Cow (Bovine) Polyclonal FAM3C Primary Antibody pour WB - ABIN2782061
Dublineau, Grison, Grandcolas, Baudelin, Tessier, Suhard, Frelon, Cossonnet, Claraz, Ritt, Paquet, Voisin, Gourmelon: Absorption, accumulation and biological effects of depleted uranium in Peyer's patches of rats. dans Toxicology 2006
Show all 2 Pubmed References
Covalent dimerization of ILEI is associated with breast cancer metastasis.
Data suggest that ILEI does not form interleukin-like four helix-bundle structures; ILEI exists as monomers and as covalent dimers; ILEI dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric ILEI appears to be involved in neoplastic invasiveness.
Results demonstrate that phenotype switching regulates ILEI expression, and that ILEI regulates partial phenotype switching in MITF (Montrer MITF Anticorps)-low melanoma cell lines.
Ectopic overexpression of UBE4A (Montrer UBE4A Anticorps), but not UBE3C (Montrer UBE3C Anticorps), in cells was downregulated in vitro migration and invasion in these cells. Cumulatively, our data reveals a novel post-translational regulatory mechanism of regulating ILEI1 expression, a protein required for metastatic progression in prostate cancer cells
Study used immunohistochemical staining and biochemical fractionation to examine the regional distribution and subcellular localization of ILEI in mouse brains and in autopsy brains of patients with Alzheimer's disease; results suggest that a decline of ILEI expression may cause accumulation of Abeta (Montrer APP Anticorps) in the brain and the eventual development of Alzheimer's disease.
FAM3C expression was dramatically increased in esophageal squamous cell carcinoma and might serve as a valuable prognostic indicator for esophageal squamous cell carcinoma patients after surgery
Altered subcellular ILEI localization strongly correlates with high tumor cell-associated uPAR (Montrer PLAUR Anticorps) protein expression.
Our findings indicate that cytoplasmic ILEI expression is a potential marker of EMT (Montrer ITK Anticorps) and tumour progression in colorectal cancer. ILEI is an independent predictive factor associated with poor prognosis in colorectal cancer.
ILEI could induce, as well as maintain, CD24 (Montrer CD24 Anticorps)(low)CD44 (Montrer CD44 Anticorps)(high) subpopulation in A549 cells treated with TGF-beta (Montrer TGFB1 Anticorps), which might explain its capability to induce metastatic progression.
At the FAM3C gene locus where rs7776725 was located, we identified several other SNPs (rs4727922, rs1803389, rs718766 and rs7793554) that were also associated with BMD (Montrer BEST1 Anticorps).
Data suggest that Ilei does not form interleukin-like four helix-bundle structures; Ilei exists as monomers and as covalent dimers; Ilei dimer exhibits a trans-linked domain swap converting an intramolecular disulfide to an intermolecular disulfide; dimeric Ilei appears to be involved in neoplastic invasiveness.
overexpression of Fam3c caused reduction of Runx2 (Montrer RUNX2 Anticorps) expression at both mRNA and protein levels. Fam3c was localized in the cytoplasm and it was not secreted outside the cell during osteoblast differentiation and therefore, may function intracellularly. Furthermore, Fam3c and TGF-beta1 (Montrer TGFB1 Anticorps) were found to regulate each other reciprocally
In obese diabetic mice, FAM3C expression was reduced in the liver, and hepatic FAM3C restoration improved insulin resistance, hyperglycemia, and fatty liver. FAM3C overexpression increased the expression of heat shock factor 1 (HSF1), calmodulin (CaM), and phosphorylated Akt and reduced that of gluconeogenic and lipogenic genes in diabetic mouse livers with the suppression of gluconeogenesis and lipid deposition.
TGF-beta (Montrer TGFB1 Anticorps) modulates the expression of Dab2 (Montrer DAB2 Anticorps) and ILEI mRNA required for epithelial-mesenchymal transdifferentiation by inducing phosphorylation of hnRNP E1 (Montrer PCBP1 Anticorps), resulting in its release from a structural, 33-nucleotide BAT (Montrer BAAT Anticorps) element in the 3'UTR (Montrer UTS2R Anticorps) of Dab2 (Montrer DAB2 Anticorps) and ILEI.
FAM3C orthologous protein, may be involved in cell differentiation and proliferation during inner ear embryogenesis
ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors.
ILEI requires cooperation with oncogenic Ras to govern hepatocellular EMT (Montrer ITK Anticorps) through mechanisms involving PDGF-R/beta (Montrer PDGFRB Anticorps)-catenin (Montrer CTNNB1 Anticorps) and PDGF (Montrer PDGFA Anticorps)-R/Stat3 (Montrer STAT3 Anticorps) signaling.
This gene is a member of the family with sequence similarity 3 (FAM3) family and encodes a secreted protein with a GG domain. A change in expression of this protein has been noted in pancreatic cancer-derived cells.
hypothetical protein LOC549860
, Protein FAM3C
, family with sequence similarity 3, member C
, protein FAM3C
, interleukin-like EMT inducer
, predicted osteoblast protein
, FAM3C-like protein