Fermitin Family Member 3 (FERMT3) Kits ELISA

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. De plus, nous expédions FERMT3 Anticorps (61) et FERMT3 Protéines (3) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
FERMT3 108101 Q8K1B8
FERMT3 83706 Q86UX7
Anti-Rat FERMT3 FERMT3 309186  
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Catalogue No. Reactivité Sensibilité Gamme Quantité Fournisseur Livraison Prix Détails
Souris 0.094 ng/mL 0.156-10 ng/mL 96 Tests Connectez-vous pour afficher 11 to 15 Days
452,57 €
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Boeuf (Vache) 0.312-20 ng/mL 96 Tests Connectez-vous pour afficher 13 to 17 Days
945,85 €
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Humain
96 Tests Connectez-vous pour afficher 13 to 17 Days
945,85 €
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Plus Kits ELISA pour FERMT3 partenaires d'interaction

Xenopus laevis Fermitin Family Member 3 (FERMT3) interaction partners

Mouse (Murine) Fermitin Family Member 3 (FERMT3) interaction partners

  1. Structure and lipid-binding properties of the kindlin-3 pleckstrin (Montrer PLEK Kits ELISA) homology domain has been reported.

  2. Mice expressing as little as 5% of kindlin-3 were viable and protected from spontaneous bleeding and infections. In vitro platelet functions, leukocyte adhesion, extravasation, and bacterial clearance were diminished. Bleeding time increased.

  3. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  4. Optimal T cell activation and B cell antibody responses in vivo require the interaction between Integrin beta2 and kindlin-3.

  5. Direct binding of kindlin-3 to integrin alphaIIbbeta3 is involved in supporting integrin alphaIIbbeta3 activation and integrin alphaIIbbeta3-dependent responses of platelets and consequently contributes significantly to arterial thrombus formation.

  6. ADAP interacts with talin and kindlin-3 to promote platelet Integrin alphaIIbbeta3 activation and stable fibrinogen binding.

  7. the requirement of Kindlin-3 for effector T cells to induce alpha4beta1 and alphaLbeta2 integrin ligand binding and stabilization of integrin-ligand bonds is critical when integrin ligand levels are low, but of less importance when integrin ligand levels are high.

  8. This is the first in vivo demonstration that Kindlin-3-stabilized integrin adhesions, although essential for lymphocyte arrest on blood vessels and interstitial motility, are not obligatory for leukocyte diapedesis.

  9. the beta-2-integrin-kindlin-3 interaction is particularly important in adhesion strengthening under shear flow, and for T-cell homing to lymph nodes, but dispensable for T cell activation which occurs in a shear-free environment

  10. Kindlin-3 is central to conversion of mechanical force to intracellular signaling via calcium influx.

Human Fermitin Family Member 3 (FERMT3) interaction partners

  1. this case report describes a female Thai patient who was diagnosed with leukocyte adhesion deficiency type III with a novel mutation in FERMT3, presenting with a humoral immune defect

  2. kindlin-3 plays an important role in maintaining a proper conformation of the resting alpha4beta1 to mediate both rolling and firm cell adhesion

  3. Kindlin-3 regulates c-Myc (Montrer MYC Kits ELISA) protein expression in the human chronic myeloid leukemia (Montrer BCL11A Kits ELISA) cell line K562.

  4. NMR studies demonstrated that the F1 loop of kindlin-3 is globally unfolded but stretches of residues assuming transient helical conformations could be detected in aqueous solution.

  5. Suppression of the Kindlin-2-integrin beta1-AKT (Montrer AKT1 Kits ELISA) regulatory axis is an alternative mechanism underlying the tumor suppressor function of miR (Montrer MLXIP Kits ELISA)-200b in esophageal squamous cell carcinoma.

  6. Kindlin-3/FERMT3 is upregulated in atherosclerotic, mainly in cells of monocytic origin and of M2 type. Simultaneous upregulation of ITGB2 (Montrer ITGB2 Kits ELISA) suggests a synergistic effect on leukocyte adherence and transmigration into the vessel wall.

  7. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

  8. A new C>T point mutation was found in exon 13 in the FERMT3 gene in an infant diagnosed with LAD (Montrer DLD Kits ELISA)-III. KINDLIN-3 expression is required for platelet aggregation and leukocyte function, but also osteoclast-mediated bone resorption.

  9. Mig-2 significantly attenuates the antitumor action of cisplatin.

  10. The data uncover a novel and unexpected tumor suppressor role of Kindlin-3 which can influence integrins targeted therapies development.

FERMT3 profil antigène

Antigen Summary

Kindlins are a small family of proteins that mediate protein-protein interactions involved in integrin activation and thereby have a role in cell adhesion, migration, differentiation, and proliferation. The protein encoded by this gene has a key role in the regulation of hemostasis and thrombosis. This protein may also help maintain the membrane skeleton of erythrocytes. Mutations in this gene cause the autosomal recessive leukocyte adhesion deficiency syndrome-III (LAD-III). Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with FERMT3

  • fermitin family member 3 (fermt3) anticorps
  • fermitin family member 3 (FERMT3) anticorps
  • fermitin family homolog 3 (Drosophila) (Fermt3) anticorps
  • fermitin family member 3 (Fermt3) anticorps
  • C79673 anticorps
  • KIND3 anticorps
  • Kindlin3 anticorps
  • MGC69069 anticorps
  • MGC88900 anticorps
  • MIG-2 anticorps
  • MIG2B anticorps
  • RGD1310168 anticorps
  • UNC112C anticorps
  • URP2 anticorps
  • URP2SF anticorps

Protein level used designations for FERMT3

fermitin family member 3 , fermitin family homolog 3 , unc-112-related protein 2 , MIG2-like protein , UNC-112 related protein 2 , kindlin 3 , kindlin-3

GENE ID SPECIES
379715 Xenopus laevis
448215 Xenopus (Silurana) tropicalis
100050011 Equus caballus
108101 Mus musculus
83706 Homo sapiens
483766 Canis lupus familiaris
309186 Rattus norvegicus
525159 Bos taurus
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