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anti-Fragile X Mental Retardation 1 (FMR1) Anticorps

The protein encoded by FMR1 binds RNA and is associated with polysomes. De plus, nous expédions FMR1 Protéines (7) et FMR1 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
FMR1 2332 Q06787
FMR1 24948 Q80WE1
FMR1 14265  
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Top anti-FMR1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 176 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Lapin Inconjugué EIA, WB Western blot analysis of FMR1 Antibody (N-term) in mouse lung tissue lysates (35 µg/lane). FMR1 (arrow) was detected using the purified Pab. 0.4 mL Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Lapin Inconjugué FACS, IHC (p), WB Formalin-fixed and paraffin-embedded human brain tissue reacted with FMR1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of FMR1 Antibody (N-term) (ABIN390866) in mouse lung tissue lysates (35 µg/lane). FMR1 (arrow) was detected using the purified polyclonal antibody. 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Humain Chèvre Inconjugué EIA, WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Fruit Fly Souris Inconjugué ICC, IF, IP, ELISA, WB 50 μL Connectez-vous pour afficher 3 to 4 Days
385,00 €
Détails
Humain Chèvre Inconjugué ELISA, IHC (p), WB 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Humain Lapin Inconjugué ICC, IF, IHC (p), IHC, WB Immunocytochemistry/Immunofluorescence: FMRP Antibody [NBP1-33460] - Paraformaldehyde-fixed HeLa, using FMRP antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with an alpha Tubulin antibody (Red) at 1:2500. Immunohistochemistry-Paraffin: FMRP Antibody [NBP1-33460] - Paraffin-embedded hepatoma; antibody dilution 1:500. 0.1 mL Connectez-vous pour afficher 3 to 5 Days
426,25 €
Détails
Rat Lapin Inconjugué WB 50 μg Connectez-vous pour afficher 11 to 14 Days
653,02 €
Détails
Humain Lapin Inconjugué WB 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Souris Inconjugué IHC, WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FMR1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FMR1. 100 μL Connectez-vous pour afficher 6 to 8 Days
366,67 €
Détails
Humain Souris Inconjugué WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FMR1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-FMR1. 100 μL Connectez-vous pour afficher 6 to 8 Days
366,67 €
Détails

FMR1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-FMR1 Anticorps mieux référencés

  1. Fruit Fly (Drosophila melanogaster) Monoclonal FMR1 Primary Antibody pour ICC, IF - ABIN108599 : Wan, Dockendorff, Jongens, Dreyfuss: Characterization of dFMR1, a Drosophila melanogaster homolog of the fragile X mental retardation protein. dans Molecular and cellular biology 2000 (PubMed)
    Show all 7 references for ABIN108599

  2. Rat (Rattus) Polyclonal FMR1 Primary Antibody pour WB - ABIN610747 : Anderson, Teutsch, Dong, Wortis: An essential role for Bruton's [corrected] tyrosine kinase in the regulation of B-cell apoptosis. dans Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 2 references for ABIN610747

  3. Human Polyclonal FMR1 Primary Antibody pour EIA, WB - ABIN453027 : Yuhas, Walichiewicz, Pan, Zhang, Casillas, Hagerman, Tassone: High-risk fragile x screening in Guatemala: use of a new blood spot polymerase chain reaction technique. dans Genetic testing and molecular biomarkers 2009 (PubMed)

  4. Human Polyclonal FMR1 Primary Antibody pour ELISA, IHC (p) - ABIN451678 : Hanson, Blank, Valenzuela, Garner, Madison: The functional nature of synaptic circuitry is altered in area CA3 of the hippocampus in a mouse model of Down's syndrome. dans The Journal of physiology 2007 (PubMed)

  5. Human Polyclonal FMR1 Primary Antibody pour EIA, WB - ABIN452426 : Dölen, Osterweil, Rao, Smith, Auerbach, Chattarji, Bear: Correction of fragile X syndrome in mice. dans Neuron 2007 (PubMed)

Plus d’anticorps contre FMR1 partenaires d’interaction

Fruit Fly (Drosophila melanogaster) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. dFMRP cooperates with Piwi in maintaining genome integrity by silencing heterochromatic genes and suppressing transposon expression.

  2. results show Fragile X Mental Retardation Protein (FMRP) shapes neuron class-specific calcium signaling in excitatory vs. inhibitory neurons in developing learning/memory circuitry, and that FMRP mediates activity-dependent regulation of calcium signaling specifically during the early-use critical period.

  3. results support a model whereby dFMRP can modulate the neurotoxicity caused by TDP-43 (Montrer TARDBP Anticorps) overexpression

  4. demonstrate that Zfrp8 genetically interacts with Fmr1 and tral (Montrer LSM14A Anticorps) in an antagonistic manner. Zfrp8 and FMRP both control heterochromatin packaging, also in opposite ways

  5. dFmr1 protein is essential for proper cardiac function and establish the fly as a new model for studying the role(s) of FraX proteins in the heart.

  6. These results show that dfmr1 acts in a neuron type-specific activity-dependent manner for sculpting dendritic arbors during early-use, critical period development of learning and memory circuitry in the Drosophila brain.

  7. upon the stimulation of replication stress, dFMR1 is associated with chromatin in a domain-specific manner, which is essential for its ability to induce the phosphorylation of H2Av (Montrer H2AFV Anticorps).

  8. FMRP inhibits translation by binding directly to the L5 protein on the 80S ribosome.

  9. FMRP negatively regulates HSPG (Montrer SDC2 Anticorps) co-receptors controlling trans-synaptic signaling during synaptogenesis

  10. FMRP and Ataxin-2 (Montrer ATXN2 Anticorps) have roles in long-term olfactory habituation and neuronal translational control

Human Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. One third of the putative mRNA targets described for FMRP appear to be transported in granules and FMRP is more abundant in granules than in polyribosomes. This observation supports a primary role for FMRP in granules biology.

  2. FMR1 gene mutation is associated with fragile X syndrome.

  3. This large study did not demonstrate any substantial association between normal-range FMR1 repeat lengths and reproductive parameters

  4. FMR1 is a highly conserved gene whose interpretation and effect on outcomes remains controversial in the reproductive health setting. Recent re-evaluations of the commonly accepted normal range have yielded interesting tools for possibly explaining unexpected outcomes in assisted reproduction

  5. Our results indicate that there is a potential association between FMR1 intermediate expanded alleles and Parkinson disease.

  6. FMR1 Gene Missense SNPs

  7. Data show that CGG repeats within the testes of a fetus carrying a full Fragile X syndrome (FXS) mutation and another fetus carrying mosaicism FXS mutation in fragile X mental retardation 1 protein (FMR1).

  8. Despite increasing use, FMR1 CGG repeats in the normal range cannot be used as a predictor of ovarian response to gonadotrophin stimulation

  9. Results suggest that the skewed X chromosome inactivation of the normal FMR1 allele may be a risk factor for the development of fragile-X-associated tremor/ataxia (Montrer USP14 Anticorps) syndrome

  10. Triplet expansion cytosine-guanine-guanine mutation dynamics of the FMR1 gene were observed in a family with primary ovarian insufficiency and tremor-ataxia (Montrer USP14 Anticorps) syndrome.

Zebrafish Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. We identified thousands of clustered RNA editing sites in the zebrafish transcriptome and showed that Fmrp biochemically interacts with the Adar2a protein. The expression levels of the adar (Montrer ADAR Anticorps) genes and Adar2 (Montrer ADARB1 Anticorps) protein increased in fmr1-/- zebrafish

  2. Loss-of-function fmr1 mutants carrying an anti-fmr1 miRNA transgene show abnormal neuronal morphology and connectivity similar to that seen in human fragile X syndrome.

Mouse (Murine) Fragile X Mental Retardation 1 (FMR1) interaction partners

  1. One third of the putative mRNA targets described for FMRP appear to be transported in granules and FMRP is more abundant in granules than in polyribosomes. This observation supports a primary role for FMRP in granules biology.

  2. Study showed that Fmr1 knock-out astrocytes affect the dendritic arborization of all subtypes of hippocampal neurons and that select populations of hippocampal neurons are more effected by this astrocyte-mediated developmental delay; specifically, the stellate neurons grown on Fmr1 knock-out astrocytes exhibit the most pervasive developmental delays

  3. The data reveal an age-dependent deficit in long-term potentiation in Fmr1KO mice, which may correlate to some of the complex age-related deficits in Fragile X syndrome.

  4. increased white matter seen in the FMR1-KO-FVB could be highlighting a structural over-connectivity, which could lead to some of the behavioral abnormalities seen with the FMR1-KO-FVB mice

  5. Study shows deficits in habituation of neural responses to repeated sounds in the Fragile X Mental Retardation gene (Fmr1) KO mice as seen in humans with fragile X syndrome.

  6. we find abnormal patterns of coupling between theta and gamma oscillations in perisomatic and dendritic hippocampal CA1 (Montrer CA1 Anticorps) local field potentials of the Fmr1 knockout mice.

  7. This study demonstrated that in the active phase of the circadian cycle, Fmr1 KO mice are hyperactive, and demonstrate reduced anxiety and impaired learning and memory.

  8. Study reveals a mechanism for the local regulation of translation by miR (Montrer MLXIP Anticorps)-181d and FMRP during axon development.

  9. Results indicate that, while the fragile X (Fmr1) mouse model effectively recapitulates many molecular and cellular aspects of fragile X syndrome, the cognitive profile of Fmr1 mice generally does not recapitulate the primary cognitive deficits in the human syndrome, even when diverse and challenging tasks are imposed.

  10. the absence of fragile X mental retardation protein (Montrer NUFIP2 Anticorps) has divergent effects on the function of individual types of ion channels not only between brain regions

FMR1 profil antigène

Profil protéine

The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene.

Gene names and symbols associated with FMR1

  • CG6203 gene product from transcript CG6203-RC (Fmr1) anticorps
  • fragile X mental retardation 1 (FMR1) anticorps
  • fragile X mental retardation 1 (Fmr1) anticorps
  • fragile X mental retardation 1 (fmr1) anticorps
  • fragile X mental retardation syndrome 1 (Fmr1) anticorps
  • AT24755 anticorps
  • BcDNA:GM08679 anticorps
  • cg6203 anticorps
  • dfmr anticorps
  • dfmr1 anticorps
  • dFmrp anticorps
  • dfxr anticorps
  • dfxr1 anticorps
  • dFXRP anticorps
  • Dmel\\CG6203 anticorps
  • dmfr1 anticorps
  • EP(3)3517 anticorps
  • fmr anticorps
  • Fmr-1 anticorps
  • fmr1 anticorps
  • Fmrp anticorps
  • FRAXA anticorps
  • FXR anticorps
  • POF anticorps
  • POF1 anticorps
  • zFMR1 anticorps

Protein level used designations for FMR1

CG6203-PA , CG6203-PB , CG6203-PC , CG6203-PD , CG6203-PE , CG6203-PF , CG6203-PG , CG6203-PH , CG6203-PI , Fmr1-PA , Fmr1-PB , Fmr1-PC , Fmr1-PD , Fmr1-PE , Fmr1-PF , Fmr1-PG , Fmr1-PH , Fmr1-PI , Fragile-X mental retardation protein , Fragile-X-related , dFmr1 , drosophila fragile X mental retardation protein , fragile X , fragile X mental retardation , fragile X mental retardation 1 , fragile X mental retardation gene , fragile X mental retardation protein , fragile X protein , fragile X related protein , fragile X-related , fragile x related , fragile-X , fragile X mental retardation protein 1 , fragile X mental retardation protein 1 homolog , fragile X mental retardation syndrome 1 homolog , fragile X mental retardation-1 protein , protein FMR-1 , ragile X mental retardation protein , fragile X mental retardation 1 protein , FMRP , mFmr1p

GENE ID SPECIES
37528 Drosophila melanogaster
465894 Pan troglodytes
2332 Homo sapiens
481070 Canis lupus familiaris
24948 Rattus norvegicus
259191 Danio rerio
422395 Gallus gallus
100155078 Sus scrofa
507482 Bos taurus
100172902 Pongo abelii
14265 Mus musculus
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