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Receptor for an unknown ligand. De plus, nous expédions G Protein-Coupled Receptor 132 Protéines (4) et beaucoup plus de produits pour cette protéine.
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coexpression of OGR1- and G2A-enhanced proton sensitivity and proton-induced calcium signals. This alteration is attributed to oligomerization of OGR1 and G2A. The oligomeric potential locates receptors at a specific site, which leads to enhanced
we found an additional novel G2A variant (G2A-b) that is the major transcript with functional response to ligand stimulation as well as G2A-a, and succeeded in discriminating proton-sensing and oxidized fatty acid-sensing activities of G2A.
G2A is a negative modifier of lymphoid leukemogenesis initiated by the BCR-ABL oncogene
In atherosclerotic plaques of human coronary arterial specimens, G2A is expressed by macrophages within the lipid-r (Montrer APOE Anticorps)ich plaques, whereas no immunoreactivity of G2A is observed in fibrous plaques where macrophages do not exist.
G2A can activate a specific combination of G proteins, and G2A/LPC (Montrer PCSK7 Anticorps)-induced apoptosis involves both G alpha(13 (Montrer GNA13 Anticorps))- and G alpha(s (Montrer GNAS Anticorps))-mediated pathways
G2A was not detected in either brain or skin vascular endothelial cell type.
G2A is a proton-sensing G-protein-coupled receptor (Montrer ADRA1A Anticorps) antagonized by lysophosphatidylcholine
Activity of the human G2A receptor is less sensitive to pH fluctuations as measured by inositol phosphate and cAMP accumulation.
results indicate that G protein-coupled receptor G2A is a receptor for 9-hydroxyoctadecadienoic acid (9-HODE) and other oxidized free fatty acids and is activated by oxidized free fatty acids
G2A latent within neutrophil secretory vesicles may facilitate signaling through lysophospholipids for neutrophil activation and calcium flux.
The authors report that macrophage PPARgamma (Montrer PPARG Anticorps) deletion in mice not only exacerbates mammary tumor development but also impairs the anti-tumor effects of rosiglitazone. Mechanistically, the authors identify Gpr132 as a novel direct PPARgamma (Montrer PPARG Anticorps) target in macrophage whose expression is enhanced by PPARgamma (Montrer PPARG Anticorps) loss but repressed by PPARgamma (Montrer PPARG Anticorps) activation.
the data suggest that G2A signaling serves to dampen intestinal inflammation via the production of IFN-gamma (Montrer IFNG Anticorps), which, in turn, enhances monocyte maturation to a less inflammatory program and ultimately reduces eosinophil-induced injury of colonic tissues
Lyso-PS signaled to macrophages in a G2A-dependent manner for their enhanced production of prostaglandin E2 (PGE2) via a calcium-dependent cytosolic phospholipase A2 (Montrer PLA2G4A Anticorps)/cyclooxygenase-mediated mechanism.
G2A is expressed predominantly by macrophages within atherosclerotic lesions at the aortic root of apolipoprotein E (Montrer APOE Anticorps)-deficient mice.
role of G2A in lysophosphatidylcholine-mediated T-cell migration
G2A signaling regulates macrophage chemotaxis to lysophosp[hatidylcholine.
data indicate the ability of lysophosphatidylcholine to stimulate macrophage & T-cell chemotaxis via G2A is not manifested in vivo & G2A-mediated proapoptotic rather than chemotactic action is most penetrant during atherogenesis
the neuritogenic effect of sPLA2 is mediated by generation of LPC and subsequent activation of G2A
Examination of lipoprotein profiles revealed elevated levels of circulating high-density lipoprotein (HDL (Montrer HSD11B1 Anticorps)) cholesterol in G2A-/- LDLR (Montrer LDLR Anticorps)-/- mice compared with their G2A+/+ LDLR (Montrer LDLR Anticorps)-/- counterparts after extended periods of diet intervention.
Endothelial G2A expression may aid in prevention of vascular inflammation and atherosclerosis.
Receptor for an unknown ligand. Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May serve as a mechanism for T- and B-cells, and other cell types, to slow their proliferation and repair damaged DNA to ensure proper replication.
G protein-coupled receptor 132
, probable G-protein coupled receptor 132-like
, G2 accumulation protein
, probable G-protein coupled receptor 132
, G protein-coupled receptor G2A
, G protein-coupled receptor G2a