anti-GTP Cyclohydrolase 1 (GCH1) Anticorps

GCH1 encodes a member of the GTP cyclohydrolase family. De plus, nous expédions GTP Cyclohydrolase 1 Protéines (12) et GTP Cyclohydrolase 1 Kits (5) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
GCH1 2643 P30793
GCH1 14528 Q05915
GCH1 29244 P22288
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Top anti-GTP Cyclohydrolase 1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 93 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Humain Souris Inconjugué WB GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GCH1 expression in IMR-32 on formalin-fixed paraffin-embedded human lymph node (antibody concentration 3 µg/mL). 0.1 mg Connectez-vous pour afficher 12 to 16 Days
454,76 €
Détails
Humain Lapin Inconjugué IP, IHC, ELISA, WB 0.1 mg Connectez-vous pour afficher 6 to 11 Days
368,76 €
Détails
Humain Souris Inconjugué ELISA Detection limit for recombinant GST tagged GCH1 is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Connectez-vous pour afficher 12 to 16 Days
454,76 €
Détails
Boeuf (Vache) Lapin Inconjugué WB WB Suggested Anti-GCH1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: COLO205 cell lysate 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Chèvre Inconjugué ELISA, WB Western Blot: GCH1 Antibody [NBP1-20923] - (0.5ug/ml) staining of Human Tonsil lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Humain Lapin Inconjugué DB, EIA, WB   0.1 mg Connectez-vous pour afficher 8 to 10 Days
462,00 €
Détails
Humain Lapin Inconjugué DB, EIA, WB   0.1 mg Connectez-vous pour afficher 8 to 10 Days
462,00 €
Détails
Humain Lapin Inconjugué IHC (p), WB GCH1 Antibody (N-term) (ABIN652021) western blot analysis in ZR-75-1 cell line lysates (35 µg/lane). This demonstrates the GCH1 antibody detected the GCH1 protein (arrow). GCH1 Antibody (N-term) (ABIN652021) immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Connectez-vous pour afficher 14 to 16 Days
335,24 €
Détails
Boeuf (Vache) Lapin Inconjugué WB Host: Rabbit Target Name: GCH1 Sample Tissue: Human Fetal Heart Antibody Dilution: 1ug/ml 100 μL Connectez-vous pour afficher 6 to 8 Days
358,51 €
Détails
Humain Souris Inconjugué IHC (p), IP, ELISA, WB Immunoperoxidase of monoclonal antibody to GCH1 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml] GCH1 monoclonal antibody (M01), clone 4A12 Western Blot analysis of GCH1 expression in IMR-32 . 100 μg Connectez-vous pour afficher 7 to 8 Days
369,60 €
Détails

GCH1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-GTP Cyclohydrolase 1 Anticorps mieux référencés

  1. Human Monoclonal GCH1 Primary Antibody pour IHC (p), IP - ABIN561018 : Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: Regulation of tetrahydrobiopterin biosynthesis by shear stress. dans Circulation research 2007 (PubMed)
    Show all 11 references for 561018

  2. Human Monoclonal GCH1 Primary Antibody pour WB - ABIN396170 : Dabo, Grönbladh, Nyberg, Sundström-Poromaa, Akerud: Different SNP combinations in the GCH1 gene and use of labor analgesia. dans Molecular pain 2010 (PubMed)
    Show all 5 references for 396170

  3. Human Monoclonal GCH1 Primary Antibody pour ELISA - ABIN395099 : Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. dans Diabetes Care 2010 (PubMed)
    Show all 5 references for 395099

  4. Human Polyclonal GCH1 Primary Antibody pour DB, EIA - ABIN493045 : Bergqvist, Werner, Apelqvist, Bugge, Wachter, Bengtsson: Brain biopterin metabolism in chronic experimental hepatic encephalopathy. dans Metabolic brain disease 1995 (PubMed)
    Show all 3 references for 493045

  5. Human Polyclonal GCH1 Primary Antibody pour DB, EIA - ABIN493043 : Chen, Kallwitz, Leff, Cochran, Mufson, Kordower, Mandel: Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra. dans The Journal of comparative neurology 2000 (PubMed)
    Show all 3 references for 493043

  6. Human Polyclonal GCH1 Primary Antibody pour ELISA, WB - ABIN451682 : Tegeder, Costigan, Griffin, Abele, Belfer, Schmidt, Ehnert, Nejim, Marian, Scholz, Wu, Allchorne, Diatchenko, Binshtok, Goldman, Adolph, Sama, Atlas, Carlezon, Parsegian, Lötsch, Fillingim, Maixner et al.: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. ... dans Nature medicine 2006 (PubMed)

  7. Human Polyclonal GCH1 Primary Antibody pour IP, IHC - ABIN1584545 : Meng, Liang, Li, Chen, Liu, Li: Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury. dans Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013 (PubMed)

Plus d’anticorps contre GTP Cyclohydrolase 1 partenaires d’interaction

Human GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. This study demonstrated that whole-exome sequencing show reveled GCH1 mutation with early-onset generalized dystonia.

  2. Deletion of GCH1 likely contributes to dopa-responsive dystonia.

  3. High GCH1 expression is associated with esophageal squamous cell carcinoma.

  4. Dopa-responsive dystonia phenotype may have heterogeneous genetic background and may be caused by point mutations or rearrangements in the GCH1 gene as well as in the PARK2 (Montrer PARK2 Anticorps) gene.

  5. This study found that rs11158026 (GCH1) is associated with Parkinson disease in Iran population.

  6. No association between the GCH1 pain-protective haplotype and cervical dilation was found, but a previously demonstrated association with increased use of second-line analgesia was confirmed.

  7. GTPCH/Ang-1 (Montrer ANGPT1 Anticorps) interaction in stromal fibroblasts and activation of Tie2 (Montrer TEK Anticorps) on breast tumor cells could play an important role in supporting breast cancer growth. GTPCH may be an important mechanism of paracrine tumor growth and hence a target for therapy in breast cancer.

  8. suggest that the GCH1 and MIR4697 but not SIPA1L2 and VPS13C (Montrer vps13c Anticorps) are genetic loci influencing risk of Parkinson's disease in Taiwan

  9. The risk of orofacial clefts is associated with variants of the GCH1 gene related to BH4 metabolism.

  10. Exonic deletion in the GCH1 gene only accounted for the etiology in a small percentage of patients with sporadic dopa-responsive dystonia in our Han Chinese cohort.

Mouse (Murine) GTP Cyclohydrolase 1 (GCH1) interaction partners

  1. Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart.

  2. gene expression analysis after iNOS (Montrer NOS2 Anticorps) induction identified 78 genes that were altered between wild-type and Gch1(fl/fl (Montrer FLT3LG Anticorps))Tie2cre macrophages

  3. Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.

  4. There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.

  5. Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 (Montrer FCGR1A Anticorps) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.

  6. The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.

  7. maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy

  8. The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1 (Montrer EGLN2 Anticorps)) mouse, is reported.

  9. GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.

  10. The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response

GTP Cyclohydrolase 1 (GCH1) profil antigène

Profil protéine

This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.

Gene names and symbols associated with GCH1

  • GTP cyclohydrolase 1 (GCH1) anticorps
  • GTP cyclohydrolase 1 (gch1) anticorps
  • GTP cyclohydrolase 1 (Celly_2302) anticorps
  • GTP cyclohydrolase 1 (Celly_3166) anticorps
  • GTP cyclohydrolase 1 (Weevi_1190) anticorps
  • GTP cyclohydrolase 1 (Halhy_0838) anticorps
  • GTP cyclohydrolase 1 (Sinme_1220) anticorps
  • GTP cyclohydrolase 1 (Sphch_1077) anticorps
  • GTP cyclohydrolase 1 (Gch1) anticorps
  • DYT5 anticorps
  • DYT5a anticorps
  • DYT14 anticorps
  • Gch anticorps
  • gch1a anticorps
  • GTP-CH anticorps
  • GTP-CH-1 anticorps
  • GTPCH anticorps
  • GTPCH1 anticorps
  • HPABH4B anticorps
  • MGC89622 anticorps
  • wu:fc16b10 anticorps
  • zgc:195269 anticorps

Protein level used designations for GCH1

GTP cyclohydrolase 1 (dopa-responsive dystonia) , GTP cyclohydrolase 1 , GTP cyclohydrolase I , GTP-CH-I , dystonia 14 , guanosine 5'-triphosphate cyclohydrolase I , GTP cyclohydrolase I (form A; N-terminus)

GENE ID SPECIES
286815 Bos taurus
609393 Canis lupus familiaris
695675 Macaca mulatta
743728 Pan troglodytes
448485 Xenopus (Silurana) tropicalis
10264325 Cellulophaga lytica DSM 7489
10265204 Cellulophaga lytica DSM 7489
10282422 Weeksella virosa DSM 16922
10584999 Haliscomenobacter hydrossis DSM 1100
10725797 Sinorhizobium meliloti AK83
10741394 Sphingobium chlorophenolicum L-1
100192219 Danio rerio
100286831 Oryctolagus cuniculus
100303455 Ovis aries
2643 Homo sapiens
14528 Mus musculus
29244 Rattus norvegicus
396146 Gallus gallus
100136794 Oncorhynchus mykiss
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