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GCH1 encodes a member of the GTP cyclohydrolase family. De plus, nous expédions GTP Cyclohydrolase 1 Protéines (12) et GTP Cyclohydrolase 1 Kits (5) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 93 products:
Human Monoclonal GCH1 Primary Antibody pour IHC (p), IP - ABIN561018
Widder, Chen, Li, Dikalov, Thöny, Hatakeyama, Harrison: Regulation of tetrahydrobiopterin biosynthesis by shear stress. dans Circulation research 2007
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Human Monoclonal GCH1 Primary Antibody pour WB - ABIN396170
Dabo, Grönbladh, Nyberg, Sundström-Poromaa, Akerud: Different SNP combinations in the GCH1 gene and use of labor analgesia. dans Molecular pain 2010
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Human Monoclonal GCH1 Primary Antibody pour ELISA - ABIN395099
Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. dans Diabetes Care 2010
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Human Polyclonal GCH1 Primary Antibody pour DB, EIA - ABIN493045
Bergqvist, Werner, Apelqvist, Bugge, Wachter, Bengtsson: Brain biopterin metabolism in chronic experimental hepatic encephalopathy. dans Metabolic brain disease 1995
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Human Polyclonal GCH1 Primary Antibody pour DB, EIA - ABIN493043
Chen, Kallwitz, Leff, Cochran, Mufson, Kordower, Mandel: Age-related decreases in GTP-cyclohydrolase-I immunoreactive neurons in the monkey and human substantia nigra. dans The Journal of comparative neurology 2000
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Human Polyclonal GCH1 Primary Antibody pour ELISA, WB - ABIN451682
Tegeder, Costigan, Griffin, Abele, Belfer, Schmidt, Ehnert, Nejim, Marian, Scholz, Wu, Allchorne, Diatchenko, Binshtok, Goldman, Adolph, Sama, Atlas, Carlezon, Parsegian, Lötsch, Fillingim, Maixner et al.: GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. ... dans Nature medicine 2006
Human Polyclonal GCH1 Primary Antibody pour IP, IHC - ABIN1584545
Meng, Liang, Li, Chen, Liu, Li: Changes of GTP cyclohydrolase I and neuronal apoptosis in rat spinal dorsal cord induced by sciatic nerve injury. dans Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 2013
This study demonstrated that whole-exome sequencing show reveled GCH1 mutation with early-onset generalized dystonia.
Deletion of GCH1 likely contributes to dopa-responsive dystonia.
High GCH1 expression is associated with esophageal squamous cell carcinoma.
Dopa-responsive dystonia phenotype may have heterogeneous genetic background and may be caused by point mutations or rearrangements in the GCH1 gene as well as in the PARK2 (Montrer PARK2 Anticorps) gene.
This study found that rs11158026 (GCH1) is associated with Parkinson disease in Iran population.
No association between the GCH1 pain-protective haplotype and cervical dilation was found, but a previously demonstrated association with increased use of second-line analgesia was confirmed.
GTPCH/Ang-1 (Montrer ANGPT1 Anticorps) interaction in stromal fibroblasts and activation of Tie2 (Montrer TEK Anticorps) on breast tumor cells could play an important role in supporting breast cancer growth. GTPCH may be an important mechanism of paracrine tumor growth and hence a target for therapy in breast cancer.
suggest that the GCH1 and MIR4697 but not SIPA1L2 and VPS13C (Montrer vps13c Anticorps) are genetic loci influencing risk of Parkinson's disease in Taiwan
The risk of orofacial clefts is associated with variants of the GCH1 gene related to BH4 metabolism.
Exonic deletion in the GCH1 gene only accounted for the etiology in a small percentage of patients with sporadic dopa-responsive dystonia in our Han Chinese cohort.
Cardiomyocyte-specific overexpression of GTP cyclohydrolase I (mGCH) increases BH4 several-fold in the heart.
gene expression analysis after iNOS (Montrer NOS2 Anticorps) induction identified 78 genes that were altered between wild-type and Gch1(fl/fl (Montrer FLT3LG Anticorps))Tie2cre macrophages
Data indicate that global deficiency in GTP cyclohydrolase I (Gch1) is embryonically lethal between E11.5 and E13.5.
There is a cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
Inhibition of GCH1 prevented the Escherichia coli K1 induced expression of CD64 (Montrer FCGR1A Anticorps) in macrophages in vitro and the development of bacteremia in a newborn mouse model of meningitis.
The GTPCH I/Tetreahydrobiopterin pathway is critical to preserve endothelial progenitor cells quantity, function, and regenerative capacity during wound healing in type 1 diabetic mice.
maintenance of endothelial GTPCH I expression and the resulting improvement in BH4 biosynthesis ameliorate diabetic nephropathy
The involvement of the GCH1 gene in pain models using the hyperphenylalaninemia 1 (hph-1 (Montrer EGLN2 Anticorps)) mouse, is reported.
GTPCH1 non-covalently interacts with polyubiquitin via an ubiquitin-binding domain.
The data suggest that GCH1 inhibition reduces tumor growth by (i) direct killing of tumor cells, (ii) by inhibiting angiogenesis, and (iii) by enhancing the antitumoral immune response
This gene encodes a member of the GTP cyclohydrolase family. The encoded protein is the first and rate-limiting enzyme in tetrahydrobiopterin (BH4) biosynthesis, catalyzing the conversion of GTP into 7,8-dihydroneopterin triphosphate. BH4 is an essential cofactor required by aromatic amino acid hydroxylases as well as nitric oxide synthases. Mutations in this gene are associated with malignant hyperphenylalaninemia and dopa-responsive dystonia. Several alternatively spliced transcript variants encoding different isoforms have been described\; however, not all variants give rise to a functional enzyme.
GTP cyclohydrolase 1 (dopa-responsive dystonia)
, GTP cyclohydrolase 1
, GTP cyclohydrolase I
, dystonia 14
, guanosine 5'-triphosphate cyclohydrolase I
, GTP cyclohydrolase I (form A; N-terminus)