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may play a role in D5 dopamine receptor signal transduction and renal sodium transport. De plus, nous expédions et beaucoup plus de produits pour cette protéine.
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the current studies provide evidence showing that c-Jun (Montrer JUN Anticorps) directly binds to a consensus binding sequence within the GNA12-5' regulatory region, thereby regulating GNA12 transcription.
we conclude that Galpha12 protects HUVECs[ human umbilical vein endothelial cells ] from serum withdrawal-induced apoptosis by retaining miR (Montrer MLXIP Anticorps)-155 expression.
RGS22 (Montrer RGS22 Anticorps) acts as a tumor suppressor, repressing human pancreatic adenocarcinoma cell migration by coupling to GNA12/13.
preeclampsia is associated with decreased methylation of the GNA12 promoter
Data show that N-linked glycosylation of protease-activated receptor-1 (PAR1 (Montrer F2R Anticorps)) at extracellular loop 2 (ECL2) controls G12 (Montrer TCF3 Anticorps)/13 versus Gq G-proteins coupling specificity in response to thrombin (Montrer F2 Anticorps) stimulation.
Significance of Galpha12 upregulation in liver tumor progression, implicating Galpha12 as an attractive therapeutic target.
Results show that RMP (Montrer ABCA4 Anticorps) serves as a potent factor contributing to portal vein tumor thrombus by promoting IL-6 (Montrer IL6 Anticorps) transcription.
A tyrosine residue at the C-terminus of the Galpha subunit plays an important role in controlling activation of G-protein coupled receptors.
Galpha12gep oncogene (Montrer RAB1A Anticorps) inhibits FOXO1 (Montrer FOXO1 Anticorps), which may result from the inhibition of FOXO1 (Montrer FOXO1 Anticorps) de novo synthesis by miR (Montrer MLXIP Anticorps)-135b in conjunction with MDM2 (Montrer MDM2 Anticorps)-mediated destabilization of FOXO1 (Montrer FOXO1 Anticorps).
CREB (Montrer CREB1 Anticorps) is a critical signaling node in Lysophosphatidic acid-Lysophosphatidic acid receptor and Galpha12/gep proto-oncogene (Montrer RAB1A Anticorps) stimulated oncogenic signaling in ovarian cancer cells.
Gpr56 (Montrer GPR56 Anticorps) regulates oligodendrocyte development via interactions with Galpha12/13 and RhoA (Montrer RHOA Anticorps)
Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton.
Galpha12 is required for the development of kidney cysts induced by Pkd1 (Montrer PKD1 Anticorps) mutation in mouse autosomal dominant polycystic kidney disease.
Our data reveal a previously unknown role for Galpha12 in regulating efferocytosis and that renal tubular epithelial cells require KIM-1 (Montrer HAVCR1 Anticorps) to mediate this process.
Selective inhibition of G12 (Montrer TCF3 Anticorps)/13 signaling in macrophages can augment atheroprotective B-cell populations and ameliorate atherosclerosis.
results suggest that KIM-1 (Montrer HAVCR1 Anticorps) is an endogenous protective mechanism against renal ischemia-reperfusion injury through inhibition of Galpha12.
Pkd1 (Montrer PKD1 Anticorps) mutation or deletion leads to the activation of Galpha12, which promotes the maturation of ADAM10 (Montrer ADAM10 Anticorps) that increases the shedding of E-cadherin (Montrer CDH1 Anticorps) in kidney epithelial cells.
Galpha12 may play an important role in promoting membrane trafficking and exocytosis for basal and thrombin (Montrer F2 Anticorps)-induced vWF (Montrer VWF Anticorps) secretion, in a process involving SNAP, Galpha12/13 and Galphaq (Montrer GNAQ Anticorps)/11
Data indicate that Pyk2 (Montrer PTK2B Anticorps) is a common signaling effector downstream of both G12 (Montrer TCF3 Anticorps)/13 and integrin alphaIIbbeta3 signaling, which contributes to thromboxane generation.
PRR5L (Montrer PRR5L Anticorps) degradation promotes mTORC2 (Montrer CRTC2 Anticorps)-mediated PKC-delta (Montrer PKCd Anticorps) phosphorylation and cell migration downstream of Galpha12 in fibroblasts and pulmonary fibrosis.
Expression analysis reveals that production of 5-HT7 and Galpha12 proteins in the hippocampus undergoes strong regulation with a pronounced transient increase during early postnatal stages.
may play a role in D5 dopamine receptor signal transduction and renal sodium transport
G-protein subunit alpha-12
, g alpha-12
, guanine nucleotide-binding protein subunit alpha-12
, guanine nucleotide binding protein, alpha 12
, Galpha 12
, guanine nucleotide binding protein (G protein) alpha 12