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The protein encoded by GNL3L appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. De plus, nous expédions GNL3L Anticorps (60) et GNL3L Protéines (4) et beaucoup plus de produits pour cette protéine.
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GNL3L-LDOC1 (Montrer LDOC1 Kits ELISA) interplay regulates cell proliferation through the modulation of NF-kappaB (Montrer NFKB1 Kits ELISA) pathway during tumorigenesis.
the present study provides evidence that GNL3L is exported from the nucleus in CRM1 (Montrer XPO1 Kits ELISA) dependent manner and the nuclear localization of GNL3L is important to promote 'S' phase progression during cell proliferation.
GNL3L depletion impairs ribosome production without inducing appreciable DNA damage. During evolution, GNL3L retained the role of the ancestral gene in ribosome biosynthesis, whereas the paralogous nucleostemin (Montrer E2IG3 Kits ELISA) acquired a novel genome-protective function.
differences in the relative nucleostemin (Montrer E2IG3 Kits ELISA) protein and mRNA levels may reflect the degree of proliferation of mesnchymal stem cells and can be used to characterize in vitro expansion capabilities
GNL3L bound MDM2 (Montrer MDM2 Kits ELISA) in vivo, stabilizing MDM2 (Montrer MDM2 Kits ELISA) and preventing its ubiquitylation. GNL3L depletion upregulated specific p53 (Montrer TP53 Kits ELISA) targets (Bax (Montrer BAX Kits ELISA), 14-3-3sigma and p21 (Montrer CDKN1A Kits ELISA)).
analysis uncovers an important role for Grn1p/GNL3L within this unique group of nucleolar GTPases
GNL3L is composed of distinct modules, each of which plays a specific role in molecular interactions for its nucleolar retention and subsequent function(s) within the nucleolus
work reveals a novel mechanism that negatively regulates the transcriptional function of ERRgamma (estrogen-related receptor (Montrer ESRRG Kits ELISA))by GNL3L through coactivator competition.
GNL3L mediates the mitotic increase of TRF1 (Montrer TERF1 Kits ELISA) protein and promotes the metaphase-to-anaphase transition.
The protein encoded by this gene appears to be a nucleolar GTPase that is essential for ribosomal pre-rRNA processing and cell proliferation. Two transcript variants encoding the same protein have been found for this gene.
guanine nucleotide-binding protein-like 3-like protein
, guanine nucleotide binding protein-like 3 (nucleolar)-like
, guanine nucleotide-binding protein-like 3-like protein-like
, novel GTPase