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HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. De plus, nous expédions HCST Kits (5) et HCST Protéines (4) et beaucoup plus de produits pour cette protéine.
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Human Polyclonal HCST Primary Antibody pour ELISA, WB - ABIN334384
Upshaw, Arneson, Schoon, Dick, Billadeau, Leibson: NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells. dans Nature immunology 2006
The structure of the adaptor protein dap10 has been identified in the zebrafish genome.
These results suggest that NKG2D (Montrer KLRK1 Anticorps)-DAP10 endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.
findings indicate that the functional interaction between RAGE (Montrer AGER Anticorps) and DAP10 coordinately regulates S100A8 (Montrer S100A8 Anticorps)/A9-mediated survival and/or apoptotic response of keratinocytes
TGF-beta1 (Montrer TGFB1 Anticorps) may reduce the expression of NKG2D (Montrer KLRK1 Anticorps)/DAP10 and 2B4 (Montrer CD244 Anticorps)/SAPin patients with hepatitis B.
HMBOX1 (Montrer HMBOX1 Anticorps) negatively regulates the expression of NKG2D (Montrer KLRK1 Anticorps) and the activation of the NKG2D (Montrer KLRK1 Anticorps)/DAP10 signaling pathway in NK cells.
Other gamma(c) cytokines act similarly to IL-2 (Montrer IL2 Anticorps) in up-regulating DAP10 expression and NKG2D (Montrer KLRK1 Anticorps)-DAP10 surface expression.
TGF-BETA1 (Montrer TGFB1 Anticorps) down-modulates surface NKG2D (Montrer KLRK1 Anticorps) expression by controlling the transcriptional and translational levels of DAP10.
A transgenic mouse model demonstrates that induction of tolerance in Ly49H (Montrer KLRA8 Anticorps)-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H (Montrer KLRA8 Anticorps) adaptor protein DAP12 (Montrer TYROBP Anticorps), not the DAP10 adaptor protein.
NKG2D (Montrer KLRK1 Anticorps)-DAP10 triggers human NK cell-mediated killing via a Syk (Montrer SYK Anticorps)-independent regulatory pathway.
both activated and expanded CD8 (Montrer CD8A Anticorps)+ T cells and NK cells use DAP10 for cytolysis
Downstream targets of DAP10 and DAP12 (Montrer TYROBP Anticorps) are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 (Montrer TYROBP Anticorps) dramatically reduces their lytic capacity.
Rat and mouse CD94 (Montrer KLRD1 Anticorps)/NKG2C (Montrer KLRC2 Anticorps) heterodimers bind efficiently to both DAP12 (Montrer TYROBP Anticorps) and DAP10; this binding is critically dependent on the transmembrane lysine residue of CD94 (Montrer KLRD1 Anticorps).
contributes to CD8 (Montrer CD8A Anticorps)(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection
demonstrate a previously uncharacterized interaction of SHIP1 (Montrer INPP5D Anticorps) with DAP12 (Montrer TYROBP Anticorps) that limits TREM2 (Montrer TREM2 Anticorps)- and DAP12 (Montrer TYROBP Anticorps)-dependent signaling and identify a mechanism through which SHIP1 (Montrer INPP5D Anticorps) regulates key ITAM-containing receptors by blocking the binding and activation of PI3K
selective associations with DAP10 determine stimulatory versus costimulatory activity of NKG2D (Montrer KLRK1 Anticorps)
Differential requirements for Vav (Montrer VAV1 Anticorps) proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.
The importance of Fcgr3 (Montrer CD16 Anticorps)/Cd3z (Montrer CD247 Anticorps), Hcst, and Tyrobp (Montrer TYROBP Anticorps) in the activation of NK cells in the uterus of pregnant mice is reported.
Review of immune reactions against syngeneic tumors reveals an important physiological role of DAP10 adapter protein (Montrer GRB10 Anticorps) signaling in maintaining tolerance to self, by controlling the development and activation threshold of autoreactive T cells.
DAP10 signaling is involved in adjusting the activation threshold and generation of natural killer T cells and regulatory T cells to avoid autoreactivity, but it also modulates antitumor mechanisms.
improved rejection of B16 melanomas in DAP10-deficient mice
these data demonstrate that DAP10 does associate with Ly49H (Montrer KLRA8 Anticorps) and Ly49D (Montrer Klra4 Anticorps) in primary NK cells.
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
hematopoietic cell signal transducer
, DNAX-activation protein 10
, kinase assoc pro of ~10kDa
, kinase assoc protein
, membrane protein DAP10
, phosphoinositide-3-kinase adaptor protein
, transmembrane adapter protein KAP10
, putative membrane adaptor molecule
, immunoreceptor DAP10