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HCST encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. De plus, nous expédions HCST Anticorps (31) et HCST Protéines (4) et beaucoup plus de produits pour cette protéine.
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The structure of the adaptor protein dap10 has been identified in the zebrafish genome.
These results suggest that NKG2D (Montrer KLRK1 Kits ELISA)-DAP10 endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.
findings indicate that the functional interaction between RAGE (Montrer AGER Kits ELISA) and DAP10 coordinately regulates S100A8 (Montrer S100A8 Kits ELISA)/A9-mediated survival and/or apoptotic response of keratinocytes
TGF-beta1 (Montrer TGFB1 Kits ELISA) may reduce the expression of NKG2D (Montrer KLRK1 Kits ELISA)/DAP10 and 2B4 (Montrer CD244 Kits ELISA)/SAPin patients with hepatitis B.
HMBOX1 negatively regulates the expression of NKG2D (Montrer KLRK1 Kits ELISA) and the activation of the NKG2D (Montrer KLRK1 Kits ELISA)/DAP10 signaling pathway in NK cells.
Other gamma(c) cytokines act similarly to IL-2 (Montrer IL2 Kits ELISA) in up-regulating DAP10 expression and NKG2D (Montrer KLRK1 Kits ELISA)-DAP10 surface expression.
TGF-BETA1 (Montrer TGFB1 Kits ELISA) down-modulates surface NKG2D (Montrer KLRK1 Kits ELISA) expression by controlling the transcriptional and translational levels of DAP10.
A transgenic mouse model demonstrates that induction of tolerance in Ly49H-positive natural killer (NK) cells by chronic exposure to virus-encoded ligand m157 requires signaling through the Ly49H adaptor protein DAP12 (Montrer TYROBP Kits ELISA), not the DAP10 adaptor protein.
NKG2D (Montrer KLRK1 Kits ELISA)-DAP10 triggers human NK cell-mediated killing via a Syk (Montrer SYK Kits ELISA)-independent regulatory pathway.
both activated and expanded CD8 (Montrer CD8A Kits ELISA)+ T cells and NK cells use DAP10 for cytolysis
Downstream targets of DAP10 and DAP12 (Montrer TYROBP Kits ELISA) are constitutively activated in large granular lymphocyte leukemia cells, and expression of dominant-negative DAP10 and DAP12 (Montrer TYROBP Kits ELISA) dramatically reduces their lytic capacity.
Adoptive transfer of murine T cells expressing a chimeric-PD1 (Montrer PDCD1 Kits ELISA)-Dap10 receptor may induce a preferential cytokine profile and T-cell differentiation phenotype for anti-lymphoma therapies.
Rat and mouse CD94 (Montrer KLRD1 Kits ELISA)/NKG2C (Montrer KLRC2 Kits ELISA) heterodimers bind efficiently to both DAP12 (Montrer TYROBP Kits ELISA) and DAP10; this binding is critically dependent on the transmembrane lysine residue of CD94 (Montrer KLRD1 Kits ELISA).
contributes to CD8 (Montrer CD8A Kits ELISA)(+) T cell-mediated cytotoxic effector mechanisms during Mycobacterium tuberculosis infection
demonstrate a previously uncharacterized interaction of SHIP1 (Montrer INPP5D Kits ELISA) with DAP12 (Montrer TYROBP Kits ELISA) that limits TREM2 (Montrer TREM2 Kits ELISA)- and DAP12 (Montrer TYROBP Kits ELISA)-dependent signaling and identify a mechanism through which SHIP1 (Montrer INPP5D Kits ELISA) regulates key ITAM-containing receptors by blocking the binding and activation of PI3K
selective associations with DAP10 determine stimulatory versus costimulatory activity of NKG2D (Montrer KLRK1 Kits ELISA)
Differential requirements for Vav (Montrer VAV1 Kits ELISA) proteins in DAP10- and ITAM-mediated NK cell cytotoxicity.
The importance of Fcgr3 (Montrer CD16 Kits ELISA)/Cd3z (Montrer CD247 Kits ELISA), Hcst, and Tyrobp (Montrer TYROBP Kits ELISA) in the activation of NK cells in the uterus of pregnant mice is reported.
Review of immune reactions against syngeneic tumors reveals an important physiological role of DAP10 adapter protein (Montrer GRB10 Kits ELISA) signaling in maintaining tolerance to self, by controlling the development and activation threshold of autoreactive T cells.
DAP10 signaling is involved in adjusting the activation threshold and generation of natural killer T cells and regulatory T cells to avoid autoreactivity, but it also modulates antitumor mechanisms.
improved rejection of B16 melanomas in DAP10-deficient mice
This gene encodes a transmembrane signaling adaptor that contains a YxxM motif in its cytoplasmic domain. The encoded protein may form part of the immune recognition receptor complex with the C-type lectin-like receptor NKG2D. As part of this receptor complex, this protein may activate phosphatidylinositol 3-kinase dependent signaling pathways through its intracytoplasmic YxxM motif. This receptor complex may have a role in cell survival and proliferation by activation of NK and T cell responses. Alternative splicing results in two transcript variants encoding different isoforms.
hematopoietic cell signal transducer
, DNAX-activation protein 10
, kinase assoc pro of ~10kDa
, kinase assoc protein
, membrane protein DAP10
, phosphoinositide-3-kinase adaptor protein
, transmembrane adapter protein KAP10
, putative membrane adaptor molecule
, immunoreceptor DAP10