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anti-Huntingtin Associated Protein 1 (HAP1) Anticorps

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. De plus, nous expédions HAP1 Protéines (6) et HAP1 Kits (4) et beaucoup plus de produits pour cette protéine.

afficher tous les anticorps Gène GeneID UniProt
HAP1 11792 P28352
HAP1 9001 P54257
HAP1 29430 P54256
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Top anti-HAP1 Anticorps sur anticorps-enligne.fr

Showing 10 out of 85 products:

Catalogue No. Reactivité Hôte Conjugué Application Images Quantité Fournisseur Livraison Prix Détails
Souris Chèvre Inconjugué EIA, WB AP23773PU-N HAP-1 antibody staining of Mouse Brain lysate at 0.1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Connectez-vous pour afficher 8 to 10 Days
385,00 €
Détails
Humain Chèvre Inconjugué ELISA, WB ABIN334416 (0.1µg/ml) staining of Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Souris Inconjugué ICC, FACS, IHC (fro), IF, IHC (p), IP, IHC, WB Staining of rat hypothalamus using ABIN259097. Detection of HAP1 in mouse brain lysate using ABIN259097. 0.1 mL Connectez-vous pour afficher 3 to 5 Days
363,75 €
Détails
Souris Souris Inconjugué IF, WB Western blot analysis of HAP1 on a rat cerebrum lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1:1000 dilution of the anti- HAP1 antibody. Immunoflourescence staining of PC12 cells (rat neuroblastoma, ATCC CRL 1721). 50 μg Connectez-vous pour afficher 2 to 4 Days
146,73 €
Détails
Humain Chèvre Inconjugué ELISA, WB ABIN188689 (0.1?g/ml) staining of Human Brain (Hippocampus) lysate (35?g protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Western Blot: HAP1 Antibody [ABIN1886893] - Analysis of HAP1 in human brain (Hippocampus) lysate using this antibody at 0.1 ug/ml. 0.1 mg Connectez-vous pour afficher 3 to 5 Days
388,75 €
Détails
Souris Chèvre Inconjugué ELISA, WB   100 μg Connectez-vous pour afficher 3 to 4 Days
349,82 €
Détails
Humain Lapin Inconjugué EIA, IHC (p) 50 μg Connectez-vous pour afficher 8 to 10 Days
517,00 €
Détails
Humain Chèvre Inconjugué EIA, WB 0.1 mg Connectez-vous pour afficher 8 to 10 Days
357,50 €
Détails
Humain Chèvre Inconjugué IHC (p), ELISA, WB 50 μg Connectez-vous pour afficher 11 to 14 Days
501,70 €
Détails
Humain Chèvre Inconjugué ELISA, WB 0.1 mg Connectez-vous pour afficher 6 to 8 Days
505,48 €
Détails

HAP1 Anticorps par réactivité, application, clonalité et conjugué

Attributs Application Hôte Clonalité Conjugué
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anti-HAP1 Anticorps mieux référencés

  1. Human Monoclonal HAP1 Primary Antibody pour ICC, FACS - ABIN259097 : Chan, Nasir, Gutekunst, Coleman, Maclean, Maas, Metzler, Gertsenstein, Ross, Nagy, Hayden: Targeted disruption of Huntingtin-associated protein-1 (Hap1) results in postnatal death due to depressed feeding behavior. dans Human molecular genetics 2002 (PubMed)
    Show all 6 references for ABIN259097

  2. Mouse (Murine) Monoclonal HAP1 Primary Antibody pour IF, WB - ABIN968461 : Gutekunst, Li, Yi, Ferrante, Li, Hersch: The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 (PubMed)
    Show all 5 references for ABIN968461

  3. Mouse (Murine) Polyclonal HAP1 Primary Antibody pour EIA, WB - ABIN615992 : Rong, McGuire, Fang, Sheng, Shin, Li, Li: Regulation of intracellular trafficking of huntingtin-associated protein-1 is critical for TrkA protein levels and neurite outgrowth. dans The Journal of neuroscience : the official journal of the Society for Neuroscience 2006 (PubMed)
    Show all 2 references for ABIN615992

  4. Human Polyclonal HAP1 Primary Antibody pour ELISA, WB - ABIN188689 : Takeshita, Fujinaga, Zhao, Yanai, Shinoda: Huntingtin-associated protein 1 (HAP1) interacts with androgen receptor (AR) and suppresses SBMA-mutant-AR-induced apoptosis. dans Human molecular genetics 2006 (PubMed)

Plus d’anticorps contre HAP1 partenaires d’interaction

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) interaction partners

  1. Is closely associated with upregulation of the Ref1 (Montrer THOC4 Anticorps)/Nrf2 (Montrer NFE2L2 Anticorps) signalling pathway.

  2. Results show the stimulatory effect of PARP-1 (Montrer PARP1 Anticorps) on APE1 (Montrer APEX1 Anticorps)-dependent base excision repair (BER). PARP-1 (Montrer PARP1 Anticorps) and APE1 (Montrer APEX1 Anticorps) appear to have a functional interaction in BER since PARP-1 (Montrer PARP1 Anticorps) can stimulate the strand incision activity of APE1 (Montrer APEX1 Anticorps).

  3. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

  4. Hap1 interacts with Bcr (Montrer BCR Anticorps) on microtubules to regulate neuronal differentiation.

  5. increases in APEX1 (Montrer APEX1 Anticorps) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (Montrer APEX1 Anticorps) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells

  6. Endothelial cell tumor proliferation was found to be dependent on Apex-1 (Montrer APEX1 Anticorps) expression.

  7. Expression of OGG1 (Montrer OGG1 Anticorps) and APEX1 (Montrer APEX1 Anticorps) was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 (Montrer APEX1 Anticorps) was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.

  8. Data indicate that the endonuclease activity of APE1 (Montrer APEX1 Anticorps) is required for class switch recombination (CSR (Montrer SCARA3 Anticorps)).

  9. These results suggest that mitochondrial APE1/Ref-1 (Montrer APEX1 Anticorps) is contributed to the protective role to protein kinase C (Montrer PKC Anticorps)-induced mitochondrial dysfunction in endothelial cells.

  10. Spinal motor neurones down-regulate APE1 (Montrer APEX1 Anticorps) upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions.

Human Huntingtin Associated Protein 1 (HAP1) interaction partners

  1. data fully support that HAP1 (Montrer APEX1 Anticorps) is a GKAP (Montrer DLGAP1 Anticorps), anchoring specifically to the cGMP-dependent protein kinase (Montrer CDK7 Anticorps) isoform Ibeta, and provide further evidence that also PKG (Montrer PRKG1 Anticorps) spatiotemporal signaling is largely controlled by anchoring proteins

  2. HAP1 (Montrer APEX1 Anticorps) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

  3. Overexpression of HAP1 (Montrer APEX1 Anticorps) reduced in vitro cell growth in breast cancer cell lines.

  4. The results of this study found no association was found between the HAP1 (Montrer APEX1 Anticorps) T441M polymorphism and the age at onset of Huntington's disease .

  5. The results of this study suggested that HAP1 (Montrer APEX1 Anticorps) co-localizes and associates with APP (Montrer APP Anticorps) in physiological conditions of mouse and human brain.

  6. WT HTT (Montrer HTT Anticorps) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (Montrer PCM1 Anticorps)).

  7. HAP1 (Montrer APEX1 Anticorps)/stigmoid body interacts with the normal ataxin-3 (Montrer ATXN3 Anticorps) through Josephin (Montrer ATXN3 Anticorps) domain

  8. sortilin (Montrer SORT1 Anticorps) stabilizes the proBDNF.HAP1 complex

  9. ADORA2A (Montrer ADORA2A Anticorps), but not HAP1 (Montrer APEX1 Anticorps) or OGG1 (Montrer OGG1 Anticorps), may have a role in age at onset in Huntington's disease

  10. REVIEW: function of HAP1 (Montrer APEX1 Anticorps)

HAP1 profil antigène

Profil protéine

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with HAP1

  • apurinic/apyrimidinic endonuclease 1 (Apex1) anticorps
  • huntingtin-associated protein 1 (HAP1) anticorps
  • huntingtin-associated protein 1 (Hap1) anticorps
  • APE anticorps
  • Apex anticorps
  • HAP-1 anticorps
  • HAP1 anticorps
  • HAP1-A anticorps
  • HAP1-B anticorps
  • HAP2 anticorps
  • hHLP1 anticorps
  • HIP5 anticorps
  • HLP anticorps
  • Ref-1 anticorps

Protein level used designations for HAP1

AP endonuclease 1 , APEN , APEX nuclease , DNA-(apurinic or apyrimidinic site) lyase , apurinic-apyrimidinic endonuclease 1 , redox factor-1 , HAP-1 , huntingtin-associated protein 2 , neuroan 1 , huntingtin-associated protein 1 (neuroan 1)

GENE ID SPECIES
11792 Mus musculus
9001 Homo sapiens
15114 Mus musculus
29430 Rattus norvegicus
607751 Canis lupus familiaris
618422 Bos taurus
Fournisseurs de qualité sélectionnés pour anti-HAP1 (HAP1) Anticorps
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