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Huntingtin Associated Protein 1 (HAP1) Kits ELISA

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. De plus, nous expédions HAP1 Anticorps (88) et HAP1 Protéines (6) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Souris HAP1 HAP1 11792 P28352
HAP1 9001 P54257
Anti-Rat HAP1 HAP1 29430 P54256
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Catalogue No. Reactivité Sensibilité Gamme Images Quantité Fournisseur Livraison Prix Détails
Humain 15.6 pg/mL 62.5-4000 pg/mL Typical standard curve 96 Tests Connectez-vous pour afficher 9 to 12 Days
772,39 €

Plus Kits ELISA pour HAP1 partenaires d'interaction

Mouse (Murine) Huntingtin Associated Protein 1 (HAP1) interaction partners

  1. Is closely associated with upregulation of the Ref1 (Montrer THOC4 Kits ELISA)/Nrf2 (Montrer NFE2L2 Kits ELISA) signalling pathway.

  2. Results show the stimulatory effect of PARP-1 (Montrer PARP1 Kits ELISA) on APE1 (Montrer APEX1 Kits ELISA)-dependent base excision repair (BER). PARP-1 (Montrer PARP1 Kits ELISA) and APE1 (Montrer APEX1 Kits ELISA) appear to have a functional interaction in BER since PARP-1 (Montrer PARP1 Kits ELISA) can stimulate the strand incision activity of APE1 (Montrer APEX1 Kits ELISA).

  3. Early loss of Hap1 significantly reduces postnatal hippocampal neurogenesis, and leads to adult depressive-like behavior.

  4. Hap1 interacts with Bcr (Montrer BCR Kits ELISA) on microtubules to regulate neuronal differentiation.

  5. increases in APEX1 (Montrer APEX1 Kits ELISA) level confer protection against the murine paternal age effect, thus highlighting the role of APEX1 (Montrer APEX1 Kits ELISA) in preserving reproductive health with increasing age and in protection against genotoxin-induced mutagenesis in somatic cells

  6. Endothelial cell tumor proliferation was found to be dependent on Apex-1 (Montrer APEX1 Kits ELISA) expression.

  7. Expression of OGG1 (Montrer OGG1 Kits ELISA) and APEX1 (Montrer APEX1 Kits ELISA) was decreased at 3h after last exposure to Aroclor 1254 and only the expression level of APEX1 (Montrer APEX1 Kits ELISA) was recovered at 24-h after, so inhibition of DNA repair can be a potential mode of action of Aroclor 1254 gonadal toxicity.

  8. Data indicate that the endonuclease activity of APE1 is required for class switch recombination (CSR).

  9. These results suggest that mitochondrial APE1/Ref-1 (Montrer APEX1 Kits ELISA) is contributed to the protective role to protein kinase C (Montrer PKC Kits ELISA)-induced mitochondrial dysfunction in endothelial cells.

  10. Spinal motor neurones down-regulate APE1 (Montrer APEX1 Kits ELISA) upon oxidative stress. This property renders motor neurones susceptible to continuous challenge of oxidative stress in pathological conditions.

Human Huntingtin Associated Protein 1 (HAP1) interaction partners

  1. data fully support that HAP1 (Montrer APEX1 Kits ELISA) is a GKAP (Montrer DLGAP1 Kits ELISA), anchoring specifically to the cGMP-dependent protein kinase (Montrer CDK7 Kits ELISA) isoform Ibeta, and provide further evidence that also PKG (Montrer PRKG1 Kits ELISA) spatiotemporal signaling is largely controlled by anchoring proteins

  2. HAP1 (Montrer APEX1 Kits ELISA) gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity

  3. Overexpression of HAP1 (Montrer APEX1 Kits ELISA) reduced in vitro cell growth in breast cancer cell lines.

  4. The results of this study found no association was found between the HAP1 (Montrer APEX1 Kits ELISA) T441M polymorphism and the age at onset of Huntington's disease .

  5. The results of this study suggested that HAP1 (Montrer APEX1 Kits ELISA) co-localizes and associates with APP (Montrer APP Kits ELISA) in physiological conditions of mouse and human brain.

  6. WT HTT (Montrer HTT Kits ELISA) regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1 (Montrer PCM1 Kits ELISA)).

  7. HAP1 (Montrer APEX1 Kits ELISA)/stigmoid body interacts with the normal ataxin-3 (Montrer ATXN3 Kits ELISA) through Josephin (Montrer ATXN3 Kits ELISA) domain

  8. sortilin (Montrer SORT1 Kits ELISA) stabilizes the proBDNF.HAP1 complex

  9. ADORA2A (Montrer ADORA2A Kits ELISA), but not HAP1 (Montrer APEX1 Kits ELISA) or OGG1 (Montrer OGG1 Kits ELISA), may have a role in age at onset in Huntington's disease

  10. REVIEW: function of HAP1 (Montrer APEX1 Kits ELISA)

HAP1 profil antigène

Antigen Summary

Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with huntingtin, with two cytoskeletal proteins (dynactin and pericentriolar autoantigen protein 1), and with a hepatocyte growth factor-regulated tyrosine kinase substrate. The interactions with cytoskeletal proteins and a kinase substrate suggest a role for this protein in vesicular trafficking or organelle transport. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Gene names and symbols associated with HAP1

  • apurinic/apyrimidinic endonuclease 1 (Apex1) anticorps
  • huntingtin-associated protein 1 (HAP1) anticorps
  • huntingtin-associated protein 1 (Hap1) anticorps
  • APE anticorps
  • Apex anticorps
  • HAP-1 anticorps
  • HAP1 anticorps
  • HAP1-A anticorps
  • HAP1-B anticorps
  • HAP2 anticorps
  • hHLP1 anticorps
  • HIP5 anticorps
  • HLP anticorps
  • Ref-1 anticorps

Protein level used designations for HAP1

AP endonuclease 1 , APEN , APEX nuclease , DNA-(apurinic or apyrimidinic site) lyase , apurinic-apyrimidinic endonuclease 1 , redox factor-1 , HAP-1 , huntingtin-associated protein 2 , neuroan 1 , huntingtin-associated protein 1 (neuroan 1)

11792 Mus musculus
9001 Homo sapiens
15114 Mus musculus
29430 Rattus norvegicus
607751 Canis lupus familiaris
618422 Bos taurus
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