Interferon Regulatory Factor 6 (IRF6) Kits ELISA

IRF6 encodes a member of the interferon regulatory transcription factor (IRF) family. De plus, nous expédions IRF6 Anticorps (98) et IRF6 Protéines (9) et beaucoup plus de produits pour cette protéine.

list all ELISA KIts Gène GeneID UniProt
Anti-Humain IRF6 IRF6 3664 O14896
Anti-Souris IRF6 IRF6 54139 P97431
Anti-Rat IRF6 IRF6 364081  
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Plus Kits ELISA pour IRF6 partenaires d'interaction

Human Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. CCL5 (Montrer CCL5 Kits ELISA) and CXCL11 (Montrer CXCL11 Kits ELISA) expression were also induced in response to the activation of the PKC pathway, and gene silencing experiments indicated that their inducible expression was dependent on RIPK4 (Montrer RIPK4 Kits ELISA) and IRF6. Moreover, gene reporter assays suggested that RIPK4 (Montrer RIPK4 Kits ELISA) induces CCL5 (Montrer CCL5 Kits ELISA) and CXCL11 (Montrer CXCL11 Kits ELISA) expression by stimulating the transactivation of their promoters by IRF6.

  2. IRF6 is aberrantly silenced by DNA methylation (Montrer HELLS Kits ELISA) of the 5' IRF6 CGI in melanoma

  3. In all three affecteds the known pathogenic mutation c.265A>G, p.Lys89Glu in IRF6 was identified. While inter- as well as intra-familial variability has been described in IRF6-related disorders, the occurrence of a typical Van (Montrer TNIP1 Kits ELISA) der (Montrer GDF3 Kits ELISA) Woude Syndrome without any other anomalies as well as a diagnosis of Popliteal pterygium syndrome in the same family is rare.

  4. Association between IRF6 and 8q24 polymorphisms and nonsyndromic cleft lip with or without cleft palate

  5. Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.

  6. The data presented suggest an important role for cytoplasmic IRF6 in regulating the availability or localization of the NME1 (Montrer NME1 Kits ELISA)/2 complex and thus the dynamic behavior of epithelia during lip/palate development.

  7. IRF6 dysregulation may be involved in the development of Vulvar Squamous Cell Carcinoma from vulvar lichen sclerosus (VLS). Methylation of the IRF6 promoter may be a marker of cancer risk in patients with VLS.

  8. Here, the authors have established that IRF6 promotes the differentiation of oral keratinocytes in response to Porphyromonas gingivalis.

  9. It has been shown that pathogenic IRF6 mutations are likely to occur in a small fraction (~0.3%) of individuals with apparent nonsyndromic orofacial cleft, across multiple ethnic groups.

  10. The 8q24 region plays a role in cleft lip/palate and the IRF6 G/A haplotype (rs2235371/rs642961) increases the risk for oral cleft in the Brazilian population.

Zebrafish Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. Here, we demonstrate the protein functions of human IRF6 missense gene variants could be rapidly assessed in detail by their abilities to rescue the irf6 -/- phenotype in zebrafish through variant mRNA microinjections at the one-cell stage.

  2. Fish IRF6 is distinguished from the homolog of mammals by being a positive regulator of IFN transcription and phosphorylated by MyD88 (Montrer MYD88 Kits ELISA) and TBK1 (Montrer TBK1 Kits ELISA), suggesting that differences in the IRF6 regulation pattern exist between lower and higher vertebrates.

  3. Authors report that Kruppel-like factor 17 (Klf17 (Montrer KLF17 Kits ELISA)), like Grhl3 (Montrer GRHL3 Kits ELISA), acts downstream of Irf6 in this network in zebrafish periderm.

  4. In zebrafish periderm, grainyhead-like 3 (grhl3 (Montrer GRHL3 Kits ELISA)) (an ancient regulator of the epidermal permeability barrier), was identified as acting downstream of Irf6. Simultaneous inhibition of grhl1 (Montrer GRHL1 Kits ELISA) and grhl3 (Montrer GRHL3 Kits ELISA) disrupted periderm differentiation in zebrafish.

  5. analysis of zebrafish expression of IRF6

  6. These experiments reveal a conserved role for maternally-encoded Irf6 in differentiation of a simple epithelium in X. laevis and D. rerio.

Mouse (Murine) Interferon Regulatory Factor 6 (IRF6) interaction partners

  1. Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikkalpha (Montrer CHUK Kits ELISA) and Irf6.

  2. IRF6 suppresses PPARgamma (Montrer PPARG Kits ELISA) through binding IRF (Montrer TRIM63 Kits ELISA) recognition sites located upstream of the PPARgamma (Montrer PPARG Kits ELISA) coding region. Taken together, the results suggest that an IRF6/PPARgamma (Montrer PPARG Kits ELISA) regulatory axis suppresses anti-inflammatory responses in bone marrow-derived macrophages and provides references for future study addressing dysregulated metabolic and immunologic homeostasis of obese adipose tissue.

  3. Irf6 and RTK signaling interact in regulating periderm differentiation and function, as well as provide a rationale to screen for epistatic interactions between variants in IRF6 and RTK signaling pathway genes in human orofacial clefting populations.

  4. These data provide the first mechanistic insight into the heightened caries susceptibility associated with CLP (Montrer HAPLN1 Kits ELISA) and indicate a direct role for the major CLP (Montrer HAPLN1 Kits ELISA) gene Irf6 in salivary gland development and a significant role in regulating oral immunity in mice.

  5. that downregulation of interferon regulatory factor 6 affords protection against TNI (Montrer TNNI2 Kits ELISA) through Akt (Montrer AKT1 Kits ELISA)-eNOS (Montrer NOS3 Kits ELISA) pathway-mediated antioxidative and anti-inflammatory activity

  6. Irf6 is required for resistance to Lipopolysaccharides-induced endotoxic shock. In addition, Irf6-deficient bone marrow-derived neutrophils exhibited increased chemotactic index and velocity compared with wild-type cells in vitro.

  7. TGFbeta3 increases IRF6 expression and subsequently regulates SNAI2 expression; IRF6 appears to regulate epithelial mesenchymal transition during palatal fusion via SNAI2.

  8. Pvrl1 (Montrer PVRL1 Kits ELISA) is a bona fide target gene of the transcription factor p63 (Montrer CKAP4 Kits ELISA), whereas Pvrl4 (Montrer PVRL4 Kits ELISA) regulation is linked to epidermal differentiation and is under Irf6

  9. Data suggest that Irf6 functions through the RhoA (Montrer RHOA Kits ELISA) pathway to regulate cellular migration.

  10. These results support a role for IRF6 in brain morphometry and provide evidence for a potential genetic link to abnormal brain development in orofacial clefting.

IRF6 profil antigène

Antigen Summary

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.

Gene names and symbols associated with IRF6

  • interferon regulatory factor 6 (IRF6) anticorps
  • interferon regulatory factor 6 (irf6) anticorps
  • interferon regulatory factor 6 S homeolog (irf6.S) anticorps
  • interferon regulatory factor 6 (Irf6) anticorps
  • AI876454 anticorps
  • DKFZp469E012 anticorps
  • E230028I05Rik anticorps
  • IRF6 anticorps
  • LPS anticorps
  • mirf6 anticorps
  • OFC6 anticorps
  • PIT anticorps
  • PPS anticorps
  • PPS1 anticorps
  • VWS anticorps
  • VWS1 anticorps
  • xIRF-6 anticorps
  • zgc:63500 anticorps

Protein level used designations for IRF6

interferon regulatory factor 6 , interferon regulatory factor 6-like , IRF-6

443083 Ovis aries
457701 Pan troglodytes
594908 Xenopus (Silurana) tropicalis
712958 Macaca mulatta
100174467 Pongo abelii
100402804 Callithrix jacchus
100594750 Nomascus leucogenys
3664 Homo sapiens
393570 Danio rerio
443771 Xenopus laevis
480015 Canis lupus familiaris
397521 Sus scrofa
614253 Bos taurus
54139 Mus musculus
364081 Rattus norvegicus
100349520 Oryctolagus cuniculus
419863 Gallus gallus
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