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The protein encoded by IL27 is one of the subunits of a heterodimeric cytokine complex. De plus, nous expédions IL27 Kits (51) et IL27 Protéines (23) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 194 products:
Mouse (Murine) Monoclonal IL27 Primary Antibody pour ICS, Neut - ABIN2689756
Hall, Silver, Hunter: The immunobiology of IL-27. dans Advances in immunology 2012
Show all 7 Pubmed References
Mouse (Murine) Polyclonal IL27 Primary Antibody pour WB - ABIN1043831
Pflanz, Timans, Cheung, Rosales, Kanzler, Gilbert, Hibbert, Churakova, Travis, Vaisberg, Blumenschein, Mattson, Wagner, To, Zurawski, McClanahan, Gorman, Bazan, de Waal Malefyt, Rennick, Kastelein: IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. dans Immunity 2002
Mouse (Murine) Monoclonal IL27 Primary Antibody pour WB - ABIN1043836
Murugaiyan, Mittal, Weiner: Identification of an IL-27/osteopontin axis in dendritic cells and its modulation by IFN-gamma limits IL-17-mediated autoimmune inflammation. dans Proceedings of the National Academy of Sciences of the United States of America 2010
Human Monoclonal IL27 Primary Antibody pour CyTOF, FACS - ABIN4900122
Seyerl, Kirchberger, Majdic, Seipelt, Jindra, Schrauf, Stöckl: Human rhinoviruses induce IL-35-producing Treg via induction of B7-H1 (CD274) and sialoadhesin (CD169) on DC. dans European journal of immunology 2010
IL-27 polymorphisms might play a protective role for the development of ulcerative colitis in the Mexican population
IL-27 stimulation activated STAT1 (Montrer STAT1 Anticorps) and STAT3 (Montrer STAT3 Anticorps) in HeLa and T98G cells, suggesting that IL-27 engages the STAT1 (Montrer STAT1 Anticorps)/3 pathway, which then leads to the upregulation of IL-6 (Montrer IL6 Anticorps), IP-10 (Montrer CXCL10 Anticorps), and MIG (Montrer CXCL9 Anticorps)
IL-27 and IL-37 limit the induction of particular T cell subsets along with cytokine responses in S. stercoralis infections, which suggest the importance of IL-27 and IL-37 in immune modulation in a chronic helminth infection.
IL-27 is a pivotal regulator in endometriotic immune tolerance by triggering Th17 cells to produce IL-10 (Montrer IL10 Anticorps).
HIV and Tat (Montrer TAT Anticorps) inhibit LPS (Montrer IRF6 Anticorps)-induced IL-27 production in human macrophages via distinct mechanisms: Tat (Montrer TAT Anticorps) through the inhibition of cIAP-1 (Montrer BIRC2 Anticorps)-TRAF-6 (Montrer TRAF6 Anticorps) and subsequent inhibition of PI3K (Montrer PIK3CA Anticorps) and p38 (Montrer CRK Anticorps) MAPKs, whereas HIV through the inhibition of p38 MAPK (Montrer MAPK14 Anticorps) activation.
IL27 (Montrer EBI3 Anticorps) recapitulates IFN-gamma (Montrer IFNG Anticorps) responses in hepatocellular carcinoma cells, but is inhibited by IL6 (Montrer IL6 Anticorps)-type cytokines.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (Montrer IL1B Anticorps) secretion levels triggered by dual LPS (Montrer IRF6 Anticorps)-ATP stimulation.
IL-27 enhanced the cytotoxicity and suppressed the proliferation of ovarian cancer cells
the sIL (Montrer PMEL Anticorps)-6R/p28 (Montrer PSMD10 Anticorps) fusion protein (FP) upregulated IFN-lambda1 expression by increasing the binding abilities of c-Fos and activating transcription factor 1 (Montrer AFT1 Anticorps) to the IFN-lambda1 promoter via the p38 MAPK (Montrer MAPK14 Anticorps) signaling pathway; results demonstrate the important role of sIL (Montrer PMEL Anticorps)-6R/p28 (Montrer PSMD10 Anticorps) FP in mediating virus-induced type III IFN production.
These results identify IL-27 and its specific receptor IL27RA (Montrer IL27RA Anticorps) as a critical immune axis for the antiviral immune response and as robust correlates of viral load and proviral reservoir size in mononuclear leukocytes in HIV infection.
IL-27-induced Sca-1 (Montrer Ly6a Anticorps)(+) T cells had increased expression of effector/memory-associated transcription factor T-bet, Eomes (Montrer EOMES Anticorps) and Blimp1 (Montrer PRDM1 Anticorps).
found that during respiratory virus infection the prototypic inflammatory cytokine IL-6 (Montrer IL6 Anticorps) is a critical anti-inflammatory regulator of viral induced immunopathology in the respiratory tract through its induction of IL-27
We demonstrate that IL-27-deficiency is linked to increased mucosal presence of ILC2 in a model of inflammatory lung disease. Moreover, IL-27-treatment inhibited ILC2 proliferation and cytokine production and significantly reduced their accumulation in vivo.
These data suggest a novel role of the sympathetic neuroendocrine system for the modulation of IL-27-dependent acute inflammation.
results identified a novel mechanism of action of IL-27 on Tregs in the context of cancers.
These findings provide new evidence that IL-27 plays an important role in the proinflammatory capacity of monocytes and macrophages via enhancing IL-1beta (Montrer IL1B Anticorps) secretion levels triggered by dual LPS (Montrer TLR4 Anticorps)-ATP stimulation.
findings show that PGE2 inhibits IL-27 production in macrophages and in splenic conventional dendritic cells; and identify a novel pathway consisting of signaling through EP2/EP4-->induction of cAMP-->downregulation of IFN regulatory factor 1 expression and binding to the p28 IFN-stimulated response element site
these data provide the first evidence that IL-27 signals directly to B (Montrer TDO2 Anticorps) cells promote GCs (Montrer UGCG Anticorps) and support the role of IL-27 in lupus.
this study shows that IL-27 plays an important role in immune response and pathogen clearance during infection with Candida parapsilosis
Inhibition of IL-27p28 also enhanced the suppressive capacity of adoptively transferred CD4 (Montrer CD4 Anticorps)(+) nTregs by increasing the stability of Foxp3 (Montrer FOXP3 Anticorps) expression.
The open reading frame of IL-27 p28 gene is 720 bp, which encodes a protein of 239 amino acids with a predicted molecular mass of 26.6 kDa. The deduced amino acid sequence of IL-27 p28 showed a high degree of homology to human (63%) and mouse (58%).
The protein encoded by this gene is one of the subunits of a heterodimeric cytokine complex. This protein is related to interleukin 12A (IL12A). It interacts with Epstein-Barr virus induced gene 3 (EBI3), a protein similar to interleukin 12B (IL12B), and forms a complex that has been shown to drive rapid expansion of naive but not memory CD4(+) T cells. The complex is also found to synergize strongly with interleukin 12 to trigger interferon gamma (IFNG) production of naive CD4(+) T cells. The biological effects of this cytokine are mediated by the class I cytokine receptor (WSX1/TCRR).
IL-27 p28 subunit
, IL-27 subunit alpha
, interleukin 30
, interleukin-27 subunit alpha
, interluekin 27
, interleukin 27
, interleukin 27 p28 subunit