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KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. De plus, nous expédions Keratin 8 Protéines (53) et Keratin 8 Kits (17) et beaucoup plus de produits pour cette protéine.
Showing 10 out of 735 products:
Human Monoclonal KRT8 Primary Antibody pour FACS, IHC (fro) - ABIN112173
Ivanyi, Groeneveld, Van Doornewaard, Mooi, Hageman: Keratin subtypes in carcinomas of the uterine cervix: implications for histogenesis and differential diagnosis. dans Cancer research 1990
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Human Monoclonal KRT8 Primary Antibody pour IHC (fro), IF - ABIN1106942
Odin, Obrink: Quantitative determination of the organ distribution of the cell adhesion molecule cell-CAM 105 by radioimmunoassay. dans Experimental cell research 1987
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Hamster Monoclonal KRT8 Primary Antibody pour IHC (fro), IF - ABIN112171
Bártek, Vojt?sek, Stasková, Bártková, Kerekés, Rejthar, Kovarík: A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology. dans The Journal of pathology 1991
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Human Polyclonal KRT8 Primary Antibody pour IF, IHC (p) - ABIN197582
Nakamichi, Hatakeyama, Nakayama: Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18. dans Molecular biology of the cell 2002
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Human Monoclonal KRT8 Primary Antibody pour FACS, IHC (fro) - ABIN112350
Guelstein, Tchypysheva, Ermilova, Litvinova, Troyanovsky, Bannikov: Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. dans International journal of cancer. Journal international du cancer 1988
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Human Monoclonal KRT8 Primary Antibody pour IHC (fro), IHC (p) - ABIN114674
Waseem, Karsten, Leigh, Purkis, Waseem, Lane: Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability. dans Biochemistry 2004
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Chicken Polyclonal KRT8 Primary Antibody pour IHC, WB - ABIN2777113
Moon, Yau, Wright, Zahradka: Injury-induced expression of cytokeratins 8 and 18 by vascular smooth muscle cells requires concurrent activation of cytoskeletal and growth factor receptors. dans Canadian journal of physiology and pharmacology 2008
Human Monoclonal KRT8 Primary Antibody pour ICC, IHC - ABIN969080
Walker, Harris, Holloway, McKenzie, Wells, Robinson, Morris: Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. dans Cancer genetics and cytogenetics 2007
Cow (Bovine) Polyclonal KRT8 Primary Antibody pour IHC, WB - ABIN2777112
Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: Transcriptome analysis of human gastric cancer. dans Mammalian genome : official journal of the International Mammalian Genome Society 2005
Data show that after siRNA transfection, TGF-beta1 (Montrer TGFB1 Anticorps) protein level was decreased, and CK18 (Montrer KRT18 Anticorps) proteins was decreased, while CK8 proteins was increased, and TERT (Montrer TERT Anticorps) protein expression was slightly increased at 96 h.
The interplay between Solo protein and keratin 8/keratin 18 filaments plays a crucial role in tensile force-induced RhoA activation and consequent actin cytoskeletal reinforcement in endothelial cells.
K8/18 filaments provide resistance to apoptosis in granulosa cell tumor cells by impairing FAS (Montrer FAS Anticorps) expression.
These metastatic tumors revealed no detectable expression of CK8/18, E-cadherin (Montrer CDH1 Anticorps), VCAM-1 (Montrer VCAM1 Anticorps), and ICAM-1 (Montrer ICAM1 Anticorps)
Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC (Montrer UCN3 Anticorps))-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A (Montrer PPP2R4 Anticorps)) through alpha4 phosphoprotein (Montrer IGBP1 Anticorps) by caveolin-1 (cav-1 (Montrer CAV1 Anticorps)).
In human failing myocardium, where TNF-alpha (Montrer TNF Anticorps) expression is upregulated, K8/K18 (Montrer KRT18 Anticorps) were also ectopically expressed
Human KRT8 variants promote acetaminophen induced hepatotoxicity in mouse models.
Syndecan-1 (Montrer SDC1 Anticorps) is involved in morphogenesis of the developing tooth crown and cervical loops, andntogether with CK8 and vimentin (Montrer VIM Anticorps) in differentiation of preameloblasts and preodontoblasts.
This is the first time intestinal cells have been suggested also functionally impaired by K8/K18 (Montrer KRT18 Anticorps) mutations.
Study indicates that Piwil2 (Montrer PIWIL2 Anticorps) plays a role in Fas (Montrer FAS Anticorps)-mediated apoptosis and can affect p53 (Montrer TP53 Anticorps) phosphorylation in tumor cells, revealing a novel mechanism of Piwil2 (Montrer PIWIL2 Anticorps) in apoptosis, and supports that Piwil2 (Montrer PIWIL2 Anticorps) plays an active role in tumorigenesis.
This study reveals clear genetic-statistical evidence for a link of KRT8, FAF1 (Montrer FAF1 Anticorps) and PTH1R (Montrer PTH1R Anticorps) with some of leg weakness related traits in pigs.
Mechanical injury of vascular smooth muscle up-regulated keratin 8.
Results did not support that K8/K18 (Montrer KRT18 Anticorps) filaments influence the expression of Fas (Montrer FAS Anticorps) on the surface of luteal cells.
Krt8 deletion (Krt8(-/-)) in a mouse model of cystic fibrosis (Montrer S100A8 Anticorps) (F508del-Cftr (Montrer CFTR Anticorps) mice) increased the levels of circulating markers of bone formation, corrected the expression of osteoblast phenotypic genes, promoted trabecular bone formation and improved bone mass and microarchitecture. Krt8 deletion corrected overactive NF-kappaB (Montrer NFKB1 Anticorps) signaling & decreased Wnt (Montrer WNT2 Anticorps)-beta-catenin (Montrer CTNNB1 Anticorps) signaling induced by F508del-Cftr (Montrer CFTR Anticorps) mutation in osteoblasts.
Autoantibodies to several antigens were identified in 81% of K8-null male mice 8 mo or older. Similar autoantibodies were detected in aging K18 (Montrer KRT18 Anticorps)-null male mice that had a related liver phenotype but normal colon compared with K8-null mice
The regulation of the SCFA-MCT1 (Montrer MCTS1 Anticorps)-HMGCS2 (Montrer HMGCS2 Anticorps) axis is disrupted in K8(-/-) colonocytes, suggesting a role for keratins in colonocyte energy metabolism and homeostasis.
In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels.
The findings demonstrate the near complete loss of K8/K18 (Montrer KRT18 Anticorps) with concomitant high levels of vimentin (Montrer VIM Anticorps) in CT26 (Montrer DDX53 Anticorps) cells, a chemically-induced mouse colonic tumor.
Directed expression of a chimeric type II keratin (Montrer KRT80 Anticorps) partially rescues keratin 5 (Montrer KRT36 Anticorps)-null mice.
Keratin 8 is required for the maintenance of architectural structure in thymus epithelium.
A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B (Montrer PTPN1 Anticorps) promotes keratin 8 protein insolubility and filament organization.
K8 acetylation at Lys (Montrer LYZ Anticorps)-207, a highly conserved residue among type II keratins, is up-regulated upon hyperglycemia and down-regulated by SIRT2 (Montrer SIRT2 Anticorps).
Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18.
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
, keratin complex 2, basic, gene 5
, cytokeratin 8
, keratin, type II cytoskeletal 8
, type-II keratin Kb8
, cytokeratin endo A
, keratin complex 2, basic, gene 8
, keratin, type 2, gene 8